203

Genetics

203.202 Genetic Analysis15 credits
A general course on methods and applications of genetic analysis. Topics include genetic variation, cytogenetics, gene inheritance, gene mapping, gene function, quantitative genetics, population genetics and evolution, cell and developmental biology.

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203.203 Human Genetics15 credits
Aspects of genetics that are important in human biology. Topics include chromosome abnormalities, genes and genetic disease, immunogenetics, cancer, ageing, complex traits, family studies and populations.

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203.212 Principles of Genetics15 credits
A general course on the principles and applications of genetics, with an emphasis on problem solving. Topics include gene structure, function and variation, genetic inheritance, cellular genetics and cytogenetics, population and quantitative genetics, genomics, and methods of genetic analysis.

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203.300 DNA Technology15 credits
DNA structure, topology and recombination. The contributions of bacteriophage to DNA technology. Advanced applications of DNA sequencing, gene cloning, PCR, microarrays and gene targeting, including molecular diagnostics of genetic disorders. Practical experience will be gained with DNA quantification, molecular cloning, PCR, DNA sequencing, molecular diagnostics of genetic disorders, computer analysis and expression of heterologous genes.

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203.305 Advanced Practical Genetics15 credits
An advanced course in laboratory techniques used in Genetics. Emphasis is on understanding the theory behind the methods used, on data evaluation and on the application of genetic techniques to various questions in biology. Practicals include microarray analysis, transposon tagging, human microsatellite and SNP analysis and reporter gene expression.

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203.307 Mammalian Cell Biology15 credits
A course with a strong emphasis on the structure and function of mammalian cells. Topics covered include chromosome structure and function, cell cycle, signal transduction, cytoskeleton and molecular motors, cell adhesions and interactions, cell motility, stem cells and their biomedical potential, cell death and cancer. The practical component has a strong emphasis on biochemical, genetic and microscopic methods that are used to study eukaryotic cells.

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203.328 Genome Analysis15 credits
An interactive and self-directed learning approach will be used to explore the analysis of genomes, transcriptomes, proteomes and metabolomes. The emphasis will be on understanding and applying a range of methodologies involved in extracting biologically significant information from both existing and novel data sets.

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203.340 Applied Molecular Biology15 credits
A course on the advanced methods and applications of molecular biology. Topics include an historical overview, the contributions of bacteriophage to molecular biology, PCR, gene cloning, protein engineering, genomics, microarrays, forensics and synthetic biology. Practical experience will be gained with PCR, molecular cloning and DNA sequencing.

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203.341 Genetics and Evolution15 credits
A course on understanding organisms at the level of the genome (the genes), the proteome (the proteins), and the population. Advances in understanding the structure, function, and evolution of the genome and proteome, with emphasis on model organisms, will be discussed. Genetic, biochemical, and evolutionary techniques used to dissect biological function will be described, as will the integration of that information to understand cellular and evolutionary processes.

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203.342 Molecular and Cellular Biology15 credits
Regulation of gene expression including chromatin structure, transcription factors, modulation of transcription (e.g. immunoglobulin genes) and post-transcriptional control mechanisms. Signal transduction, protein structure and function as it relates to proton pumps, catalytic strategies, translation and protein sorting. The structural organization of the cytoskeleton, knowledge of cell adhesion and the extracellular matrix, cell signalling mechanisms, cell cycles and vesicular transport.

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203.343 Advanced Genetics and Genomics15 credits
An advanced course on using genetics and genomics to solve modern problems in biology. The course will explore how genetics and genomics data can be used to understand ancestry and health, and how genes interact with diet and drugs to produce variation. Students will investigate ethical and counselling issues related to personal genomic data. Genetic variation, with an emphasis on humans, will be described, alongside its use in forensics. The newfound role of RNA in regulating gene expression will be covered.

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203.752 Computational Biology15 credits
This course will critically examine contemporary issues in computational biology, such as modelling and computer simulation, heuristics, and complex systems. These issues will be explored through case studies on topics such as Markov Chain Monte Carlo, maximum likelihood and approximate Bayesian computation, parallel computation, and recent applications in such areas as clustering, trees and networks.

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203.761 Molecular Evolution15 credits
Analysis of the evolution of DNA, RNA and proteins. Analysis of theories and experiments on the origin of life, especially the transition from the RNA to the protein/DNA world. Use of molecular 'fossils' in living cells to infer ancient processes. Analysis of DNA from extinct organisms. Human genetic diversity and evolution. Problems in molecular evolution.

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203.762 Genetic Analysis30 credits
An advanced course based on current literature where genetic approaches are used to understand important biological processes. Topics will include DNA recombination, plant-microbe symbiosis, plant-fungal gene interactions, the genetic basis of learning and memory and epigenetics.

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203.763 Phylogenetics15 credits
The course involves an in-depth study of the principles and practise of phylogenetic analysis. The course will emphasize an understanding of basic concepts necessary for the beginner to choose appropriate methods of analysis for different phylogenetic questions in genome science and systematic biology.

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203.791 Special Topic30 credits
 

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203.792 Special Topic15 credits
 

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203.797 Research Project in Molecular Biology15 credits
Supervised, independent research on a topic of relevance to biological science, biochemistry, microbiology, molecular biology, molecular genetics or molecular evolution.

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203.798 Research Report30 credits
 

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203.870 Research Report60 credits
 

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203.871 Thesis 90 Credit Part 145 credits
A supervised and guided independent study resulting in a published work

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203.872 Thesis 90 Credit Part 245 credits
A supervised and guided independent study resulting in a published work.

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203.875 Thesis90 credits
A supervised and guided independent study resulting in a published work.

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203.897 Thesis 120 Credit Part 160 credits
A supervised and guided independent study resulting in a published work.

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203.898 Thesis 120 Credit Part 260 credits
A supervised and guided independent study resulting in a published work.

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203.899 Thesis120 credits
A supervised and guided independent study resulting in a published work.

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203.900 PhD Genetics120 credits
 

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