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Contact details +64 (06) 356 9099 ext. 84714
My research investigates the microtubule cytoskeleton of animal cells. This cellular scaffold dictates cell organisation, genome stability and motility. These feats are accomplished through the formation of elaborate microtubule-based structures ranging from the polarised axons of neurons to the spindles of dividing cells and the flagella of sperm. How microtubules- which are found in most animal cells- selectively assemble into such intricate cellular machines remains a fundamental question in biology.
Towards addressing this, the lab utilises the Drosophila model. This system offers powerful molecular genetics and proteomics while being amenable to light microscopic approaches (e.g., multi-dimensional imaging and photo-manipulations). By applying these methods to different tissues isolated from the fly, we are identifying the factors and regulatory mechanisms responsible for different cellular functions.
We are currently performing a molecular "dissection" of the cell division machinery with an emphasis on the specialised meiotic divisions responsible for sperm generation. These studies have identified several intriguing differences in microtubule behaviour between division types and reveal unique tissue-specific regulatory mechanisms.
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Field of research codes
Biochemistry and Cell Biology (060100): Biological Sciences (060000): Cell and Nuclear Division (060402): Cell Development, Proliferation and Death (060103): Genetics (060400): Proteomics and Intermolecular Interactions (excl. Medical Proteomics) (060109)
cytoskeleton, microtubule, motor protein, kinesin, mitosis, meiosis, spermatogenesis, spindle, kinetochore, chromosome, microscopy, cell division, drosophila, aneuploidy, fertility, sterility, gamete, sperm, primary culture, spermatocyte, neuroblast, imaging, live-cell imaging, centromere, chromatin, microtubule associated protein, proteomics, genetics, segregation, cell biology, karyokinesis, cytokinesis