Dr David Popovich staff profile picture

Contact details +64 (06) 356 9099  ext. 84570

Dr David Popovich BSc, MSc, PhD

Senior Lecturer in Human Nutrition

Massey Institute of Food Science and Technology

My work is very much focused on plant secondary metabolites and potential to alter or prevent disease. I am particular interested in triterpenoids and steroidal saponins in natural products such as ginseng, soy and reishi mushrooms. I have particular fascination with edible fungi and the presence of pharmaceutical agents naturally present in different edible plant products. 

Professional

Contact details

  • Ph: 5904
    Campus: Turitea

Qualifications

  • BSc Nutritional Science - University of Toronto (1991)
  • MSc Nutritional Science - University of Toronto (1996)
  • PhD Food Science - University of British Columbia (2004)

Research Expertise

Research Interests

The overall goal of my research is to study the relationship between interesting edible plant compounds and their influence on cell death and signaling.  The strategies employed in the laboratory are to identify, characterize, transform, and enhance bioactive plant foods and extracts derived from natural health products (NHP) and medicinal plant food sources such as those utilized by traditional medicines. 

  Current Interest

1.      Cellular models to study NHPs influence on cultured adipocytes, hepatocytes and colonocytes. 

2.      Components that are cytotoxic and induce apoptosis or necrosis.

3.      NHP synergy.

4.      Phytochemistry

5.     Pharmacologically active edible plants

6.      Vegetable based protein

 

 

Thematics

Health and Well-being, Future Food Systems

Area of Expertise

Field of research codes
Analytical Chemistry (030100):
Biochemistry and Cell Biology (060100): Biological Sciences (060000): Cell Development, Proliferation and Death (060103):
Chemical Science (030000):
Proteomics and Intermolecular Interactions (excl. Medical Proteomics) (060109)

Research Projects

Summary of Research Projects

Position Current Completed
Project Leader 1 0

Research Outputs

Journal

Tan, JS., Yeo, CR., & Popovich, DG. (2017). Fermentation of protopanaxadiol type ginsenosides (PD) with probiotic Bifidobacterium lactis and Lactobacillus rhamnosus. Applied Microbiology and Biotechnology. 101(13), 5427-5437
[Journal article]Authored by: Popovich, D.
Phuc, DTH., & Popovich, DG. (2017). Screening for paclitaxel and other taxanes in kernel and shell of Corylus avellana (Hazelnut). Journal of Pharmacognosy and Phytochemistry. 6(2), 247-254
[Journal article]Authored by: Popovich, D.
Yeo, CR., Yong, JJ., & Popovich, DG. (2017). Isolation and characterization of bioactive polyacetylenes Panax ginseng Meyer roots. Journal of Pharmaceutical and Biomedical Analysis. 139, 148-155
[Journal article]Authored by: Popovich, D.
Ruan, W., Wei, Y., & Popovich, DG. (2015). Distinct Responses of Cytotoxic Ganoderma lucidum Triterpenoids in Human Carcinoma Cells. Phytotherapy Research. 29(11), 1744-1752
[Journal article]Authored by: Popovich, D.
Ruan, W., Lim, AHH., Huang, LG., & Popovich, DG. (2014). Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth. Natural Product Research. 28(24), 2264-2272
[Journal article]Authored by: Popovich, D.
Ruan, W., Lim, AHH., Huang, LG., & Popovich, DG. (2014). Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth. Natural Product Research.
[Journal article]Authored by: Popovich, D.
Popovich, DG., Sia, SY., Zhang, W., & Lim, ML. (2014). The color and size of chili peppers (Capsicum annuum) influence Hep-G2 cell growth. International Journal of Food Sciences and Nutrition. 65(7), 881-885
[Journal article]Authored by: Popovich, D.
Wei, Y., & Popovich, DG. (2013). Red azaphilone pigments extracted from red yeast rice induces cellular senescence and reduces viability in HepG2 cells. Biomedicine and Preventive Nutrition. 3(4), 331-337
[Journal article]Authored by: Popovich, D.
Popovich, DG., Yeo, C., & Zhang, W. (2012). Ginsenosides derived from Asian (Panax ginseng), American ginseng (Panax quinquefolius) and potential cytoactivity. International Journal of Biomedical and Pharmaceutical Sciences. 6(1), 56-62 Retrieved from http://www.globalsciencebooks.info/JournalsSup/images/Sample/IJBPS_6(SI1)56-62o.pdf
[Journal article]Authored by: Popovich, D.
Wei, Y., & Popovich, DG. (2012). Pleiotropic effects of red yeast rice (Monascus Purpureus). , 307-318
[Journal article]Authored by: Popovich, D.
Ruan, W., & Popovich, DG. (2012). Evidence of bioactivity from Ganoderma Lucidum triterpenoids in cultured cell models. , 145-156
[Journal article]Authored by: Popovich, D.
Yeo, CR., & Popovich, DG. (2012). Potential of triterpenoids from ginseng (Panax Quinquefolius and Panax Ginseng C.A. meyer) to regulate cultured adipocytes. , 123-134
[Journal article]Authored by: Popovich, D.
Zhang, W., & Popovich, DG. (2012). Recent developments of soyasaponins from soy (Glycine Max (L.)) bioactivity in cell models. , 157-162
[Journal article]Authored by: Popovich, D.
Kitts, DD., Hu, C., Popovich, DG., & Wijewickreme, AN. (2009). CHEMISTRY AND BIOACTIVITY OF NORTH AMERICAN AND ASIAN DEVIL'S CLUB (OPLOPANAX HORRIDUS). PHARMACEUTICAL BIOLOGY. 47, 26-26
[Journal article]Authored by: Popovich, D.
Popovich, DG., Yeo, SY., & Zhang, W. (2009). THE EFFECT OF GINSENG (PANAX QUINQUEFOLIUS) AND LICORICE (GLYCYRRHIZA URALENSIS) ROOT EXTRACT COMBINATION ON CULTURED HEPATOCARCINOMA CELL VIABILITY. PHARMACEUTICAL BIOLOGY. 47, 7-8
[Journal article]Authored by: Popovich, D.
Zhang, W., & Popovich, DG. (2009). SOYASAPONINS I AND III DERIVED FROM SOY FLOUR INDUCE APOPTOSIS IN HEP-G2 CELLS. PHARMACEUTICAL BIOLOGY. 47, 34-34
[Journal article]Authored by: Popovich, D.
Popovich, DG., & Kitts, DD. (2004). Generation of ginsenosides Rg3 and Rh2 from North American ginseng. PHYTOCHEMISTRY. 65(3), 337-344
[Journal article]Authored by: Popovich, D.
Kitts, DD., & Popovich, DG. (2003). Ginseng. , 78-92
[Journal article]Authored by: Popovich, D.
Jenkins, DJ., Popovich, DG., Kendall, CW., Rao, AV., Wolever, TM., Tariq, N., . . . Cunnane, SC. (1997). Metabolic Effects of Non-absorbable Carbohydrates.. Scand J Gastroenterol. 32 Suppl 222, 10-13
[Journal article]Authored by: Popovich, D.
Kendall, CWC., Popovich, DG., Wolever, TMS., Rao, AV., Mehling, C., Perera, T., . . . Jenkins, DIA. (1996). Effect of apple pomace on blood lipids.. FASEB JOURNAL. 10(3), 1088-1088
[Journal article]Authored by: Popovich, D.
TARIQ, N., JENKINS, DJA., DACOSTA, M., CUNNANE, SC., RYAN, M., SINGER, W., . . . KENDALL, CWC. (1995). EFFECTS OF SOLUBLE AND INSOLUBLE FIBER DIETS ON SERUM PSA LEVELS. FASEB JOURNAL. 9(4), A993-A993
[Journal article]Authored by: Popovich, D.
POPOVICH, DG., JENKINS, DJA., WOLEVER, TMS., VUKSAN, V., TARIQ, N., KENDALL, CWC., . . . PATTEN, R. (1995). SERUM UREA RESPONSE TO A DIET VERY HIGH IN FIBER FROM VEGETABLES AND FRUIT. AMERICAN JOURNAL OF CLINICAL NUTRITION. 61(4), 903-903
[Journal article]Authored by: Popovich, D.
JENKINS, DJA., POPOVICH, DG., WOLEVER, TMS., VUKSAN, V., TARIQ, N., KENDALL, CWC., . . . PATTON, R. (1995). SERUM-LIPID RESPONSE TO A DIET VERY HIGH IN FIBER FROM VEGETABLES AND FRUIT. FASEB JOURNAL. 9(4), A978-A978
[Journal article]Authored by: Popovich, D.
POPOVICH, DG., JENKINS, DJA., HUANG, J., TARIQ, N., KENDALL, CWC., DIERENFELD, ES., . . . CARROLL, RW. (1995). MACRONUTRIENT PROFILE OF A WILD WESTERN LOWLAND GORILLA DIET - POSSIBLE IMPLICATIONS FOR LIPID-LOWERING. FASEB JOURNAL. 9(3), A177-A177
[Journal article]Authored by: Popovich, D.
Wei, Y., & Popovich, DG. (2013). Red azaphilone pigments extracted from red yeast rice induces cellular senescence and reduces viability in HepG2 cells. Biomedicine and Preventive Nutrition.
[Journal article]Authored by: Popovich, D.
Zhang, W., Tang, FY., Yeo, MC., & Popovich, DG. (2012). Fermentation of group b soyasaponins with probiotic lactobacillus rhamnosus. Journal of Food Biochemistry. 36(2), 179-188
[Journal article]Authored by: Popovich, D.
Ruan, W., & Popovich, DG. (2012). Ganoderma lucidum triterpenoid extract induces apoptosis in human colon carcinoma cells (Caco-2). Biomedicine and Preventive Nutrition. 2(3), 203-209
[Journal article]Authored by: Popovich, D.
Kitts, DD., Kopec, A., Zawistowski, J., & Popovich, DG. (2012). Effects of high molecular weight alcohols from sugar cane fed alone or in combination with plant sterols on lipid profile and antioxidant status of Wistar rats. Applied Physiology, Nutrition and Metabolism. 37(5), 938-946
[Journal article]Authored by: Popovich, D.
Yeo, CR., Yang, C., Wong, TY., & Popovich, DG. (2011). A quantified ginseng (Panax ginseng C.A. Meyer) extract influences lipid acquisition and increases adiponectin expression in 3T3-L1 cells. Molecules. 16(1), 477-492
[Journal article]Authored by: Popovich, D.
Popovich, DG., Lee, Y., Li, L., & Zhang, W. (2011). Momordica charantia seed extract reduces pre-adipocyte viability, affects lactate dehydrogenase release, and lipid accumulation in 3T3-L1 cells. Journal of Medicinal Food. 14(3), 201-208
[Journal article]Authored by: Popovich, D.
Popovich, DG., Yeo, CR., & Lee, SM. (2011). Ginseng (Panax quinquefolius) reduces cell growth, lipid acquisition and increases adiponectin expression in 3T3-L1 cells. Evidence-based Complementary and Alternative Medicine. 2011
[Journal article]Authored by: Popovich, D.
Popovich, DG., Yeo, SY., & Zhang, W. (2011). Ginseng (Panax quinquefolius) and licorice (Glycyrrhiza uralensis) root extract combinations increase hepatocarcinoma cell (Hep-G2) viability. Evidence-based Complementary and Alternative Medicine. 2011
[Journal article]Authored by: Popovich, D.
Liu, J., Zhang, W., Jing, H., & Popovich, DG. (2010). Bog bilberry (vaccinium uliginosum l.) extract reduces cultured hep-g2, caco-2, and 3t3-l1 cell viability, affects cell cycle progression, and has variable effects on membrane permeability. Journal of Food Science. 75(3)
[Journal article]Authored by: Popovich, D.
Zhang, W., & Popovich, DG. (2010). Group B oleanane triterpenoid extract containing soyasaponins i and III from soy flour induces apoptosis in HEP-G2 cells. Journal of Agricultural and Food Chemistry. 58(9), 5315-5319
[Journal article]Authored by: Popovich, D.
Popovich, DG., Li, L., & Zhang, W. (2010). Bitter melon (Momordica charantia) triterpenoid extract reduces preadipocyte viability, lipid accumulation and adiponectin expression in 3T3-L1 cells. Food and Chemical Toxicology. 48(6), 1619-1626
[Journal article]Authored by: Popovich, D.
Popovich, DG., Tiaras, F., Yeo, CR., & Zhang, W. (2010). Lovastatin interacts with natural products to influence cultured hepatocarcinoma cell (Hep-G2) growth. Journal of the American College of Nutrition. 29(3), 204-210
[Journal article]Authored by: Popovich, D.
Zhang, W., & Popovich, DG. (2010). Behaviour of soyasapogenol B under optimised hydrolysis and ESI mass spec conditions. Food Chemistry. 123(4), 993-999
[Journal article]Authored by: Popovich, D.
Zhang, W., Teng, SP., & Popovich, DG. (2009). Generation of group B soyasaponins I and III by hydrolysis. Journal of Agricultural and Food Chemistry. 57(9), 3620-3625
[Journal article]Authored by: Popovich, D.
Zhang, W., & Popovich, DG. (2009). Chemical and biological characterization of oleanane triterpenoids from soy. Molecules. 14(8), 2959-2975
[Journal article]Authored by: Popovich, D.
Zhang, W., Yeo, MC., Tang, FY., & Popovich, DG. (2009). Bioactive responses of Hep-G2 cells to soyasaponin extracts differs with respect to extraction conditions. Food and Chemical Toxicology. 47(9), 2202-2208
[Journal article]Authored by: Popovich, D.
Zhang, W., & Popovich, DG. (2008). Effect of soyasapogenol A and soyasapogenol B concentrated extracts on Hep-G2 cell proliferation and apoptosis. Journal of Agricultural and Food Chemistry. 56(8), 2603-2608
[Journal article]Authored by: Popovich, D.
Elisia, I., Popovich, DG., Hu, C., & Kitts, DD. (2008). Evaluation of viability assays for anthocyanins in cultured cells. Phytochemical Analysis. 19(6), 479-486
[Journal article]Authored by: Popovich, D.
Kitts, DD., Popovich, DG., & Hu, C. (2007). Characterizing the mechanism for ginsenoside-induced cytotoxicity in cultured leukemia (THP-1) cells. Canadian Journal of Physiology and Pharmacology. 85(11), 1173-1183
[Journal article]Authored by: Popovich, D.
Elisia, I., Hu, C., Popovich, DG., & Kitts, DD. (2006). Antioxidant assessment of an anthocyanin-enriched blackberry extract. Food Chemistry. 101(3), 1052-1058
[Journal article]Authored by: Popovich, D.
Popovich, DG., Hu, C., Durance, TD., & Kitts, DD. (2005). Retention of ginsenosides in dried ginseng root: Comparison of drying methods. Journal of Food Science. 70(6)
[Journal article]Authored by: Popovich, D.
Popovich, DG., & Kitts, DD. (2004). Generation of ginsenosides Rg3 and Rh2 from North American ginseng. Phytochemistry. 65(3), 337-344
[Journal article]Authored by: Popovich, D.
Popovich, DG., & Kitts, DD. (2004). Ginsenosides 20(S)-protopanaxadiol and Rh2 reduce cell proliferation and increase sub-G1 cells in two cultured intestinal cell lines, Int-407 and Caco-2. Canadian Journal of Physiology and Pharmacology. 82(3), 183-190
[Journal article]Authored by: Popovich, D.
Popovich, DG., & Kitts, DD. (2004). Mechanistic studies on protopanaxadiol, Rh2, and ginseng (Panax quinquefolius) extract induced cytotoxicity in intestinal Caco-2 cells. Journal of Biochemical and Molecular Toxicology. 18(3), 143-149
[Journal article]Authored by: Popovich, D.
Popovich, DG., & Kitts, DD. (2002). Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line. Archives of Biochemistry and Biophysics. 406(1), 1-8
[Journal article]Authored by: Popovich, D.
Jenkins, DJA., Kendall, CWC., Popovich, DG., Vidgen, E., Mehling, CC., Vuksan, V., . . . Connelly, PW. (2001). Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function. Metabolism: Clinical and Experimental. 50(4), 494-503
[Journal article]Authored by: Popovich, D.
Jenkins, DJA., Popovich, DG., Kendall, CWC., Venketeshwer Rao, A., Wolever, TMS., Tariq, N., . . . Cunnane, SC. (1997). Metabolic effects of non-absorbable carbohydrates. Scandinavian Journal of Gastroenterology, Supplement. 32(222), 10-13
[Journal article]Authored by: Popovich, D.
Jenkins, DJA., Popovich, DG., Kendall, CWC., Vidgen, E., Tariq, N., Ransom, TPP., . . . Patten, R. (1997). Effect of a diet high in vegetables, fruit, and nuts on serum lipids. Metabolism: Clinical and Experimental. 46(5), 530-537
[Journal article]Authored by: Popovich, D.
Popovich, DG., Jenkins, DJA., Kendall, CWC., Dierenfeld, ES., Carroll, RW., Tariq, N., . . . Vidgen, E. (1997). The western lowland gorilla diet has implications for the health of humans and other hominoids. Journal of Nutrition. 127(10), 2000-2005
[Journal article]Authored by: Popovich, D.
Popovich, DG., Kendall, CWC., Ransom, TPP., Wolever, TMS., Tariq, N., Rosenberg, RS., . . . Jenkins, DJA. (1996). Glycemic index of commonly consumed foods. FASEB Journal. 10(3)
[Journal article]Authored by: Popovich, D.

Book

Popovich, DG., & Kitts, DD. (2006). Anticancer activity of ginseng and soy saponins. In AB. Awad, & PG. Bradford (Eds.) Nutrition and Cancer Prevention. Boca Raton: CRC Taylor & Francis
[Chapter]Authored by: Popovich, D.
Popovich, DG., & Kitts, DD. (2006). Nutrition and Cancer Prevention. In AB. Awad, & PG. Bradford (Eds.) Nutrition and Cancer Prevention. (pp. 457 - 483). : CRC Press
[Chapter]Authored by: Popovich, D.
Popovich, DG., & Kitts, DD. (2003). Ginseng. In DH. Watson (Ed.) Performance functional foods. (pp. 78 - 88). Cambridge: Woodhead Publishing LTD
[Chapter]Authored by: Popovich, D.

Conference

Popovich, DG., & Kitts, DD.Specific Ginsenosides and a North American ginseng Rh2 enriched fraction inhibits proliferation, alters membrane properties in cultured intestinal cell line (Caco-2). FASEB JOURNAL. 19 (5)(pp. A1455 - A1455). 0892-6638.
[Conference]Authored by: Popovich, D.
Popovich, DG., & Kitts, DD.Ginsenosides can inhibit proliferation and induce apoptosis in cultured leukemia and intestinal cells but effects vary according to the structure of the compounds. FASEB JOURNAL. 17 (5)(pp. A762 - A762). 0892-6638.
[Conference]Authored by: Popovich, D.

Supervision and Teaching

Summary of Doctoral Supervision

Position Current Completed
Supervisor 1 0

Current Doctoral Supervision

Supervisor of:

  • Wei Chen - Doctor of Philosophy
    Characterizing New Zealand grown ginseng (panax ginseng)

Media and Links

Media

  • 03 Dec 2015 - Online
    This One Condiment Instantly Improves Your Diet
    The article by Mandy Oaklander from Time.com describes the potential health benefits from chili peppers and the evidence was based on my published work The color and size of chili peppers (Capsicum

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