Contact details +64 (06) 356 9099  ext. 84645

Prof Bill Williams

Professor in Biophysics and Soft Matter

Institute of Fundamental Sciences

Research Projects

Summary of Research Projects

Position Current Completed
Not Specified 0 1
Project Leader 11 13
Team Member 0 1

Completed Projects

Project Title: Microstructurally engineering maximally functional dairy systems using temporal pectin modification - TIF Scholarship - Aurelie Cucheval

Microstructurally engineering maximally functional dairy systems using temporal pectin modification.
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Date Range: 2006 - 2009

Funding Body: Foundation for Research, Science & Technology

Project Team:

Project Title: Elucidating nanomechanical structure-function relationships in Nature's structural biopolymers with single molecule stretching

To be able to imitate this natural molecular change in the construction of our own materials and devices, the structure-function relationships it exploits must be understood. Recently, the molecular origin of bio-mechanical properties has been investigated, with prototypical structuring biopolymers being stretched at the single molecule level. It has been found that certain polysaccharides, which play a major role in satisfying the structural requirements of both plant cell walls and animal connective tissues, undergo conformational transitions in their sugar rings under tension. This project will investigate how such transitions are controlled and utilised in nature.
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Date Range: 2005 - 2009

Funding Body: Royal Society of New Zealand

Project Team:

Research Outputs

Journal

Owen, JL., Kent, LM., Ralet, MC., Cameron, RG., & Williams, MAK. (2017). A tale of two pectins: Diverse fine structures can result from identical processive PME treatments on similar high DM substrates. Carbohydrate Polymers. 168, 365-373
[Journal article]Authored by: Williams, M.
Irani, AH., Owen, JL., Mercadante, D., & Williams, MAK. (2017). Molecular Dynamics Simulations Illuminate the Role of Counterion Condensation in the Electrophoretic Transport of Homogalacturonans. BIOMACROMOLECULES. 18(2), 505-516
[Journal article]Authored by: Williams, M.
Kim, Y., Williams, MAK., Luzio, GA., & Cameron, RG. (2017). Introduction and characterization of charged functional domains into an esterified pectic homogalacturonan by a citrus pectin methylesterase and comparison of its modes of action to other pectin methylesterase isozymes. Food Hydrocolloids. 69, 422-431
[Journal article]Authored by: Williams, M.
Raudsepp, A., Williams, MAK., & Hall, SB. (2017). Mapping the restoring force of an optical trap in three dimensions using a two laser dual-trap approach. Journal of Modern Optics. 64(14), 1450-1456
[Journal article]Authored by: Hall, S., Raudsepp, A., Williams, M.
Xu, AY., Melton, LD., Ryan, TM., Mata, JP., Jameson, GB., Rekas, A., . . . McGillivray, DJ. (2017). Sugar-coated proteins: the importance of degree of polymerisation of oligo-galacturonic acid on protein binding and aggregation. Soft Matter. 13(14), 2698-2707
[Journal article]Authored by: Jameson, G., Williams, M.
Xu, AY., Melton, LD., Williams, MAK., & McGillivray, DJ. (2017). Protein and polysaccharide conjugates as emerging scaffolds for drug delivery systems. International Journal of Nanotechnology. 14(1-6), 470-480
[Journal article]Authored by: Williams, M.
Lian, J., Mansel, BW., Ingham, B., Prabakar, S., & Williams, MAK. (2017). Controlling chain flexibility in collagen networks to produce hydrogels with distinct properties. Soft Materials. 15(2), 145-152
[Journal article]Authored by: Williams, M.
Irani, AH., Owen, JL., Mercadante, D., & Williams, MAK. (2017). Molecular Dynamics Simulations Illuminate the Role of Counterion Condensation in the Electrophoretic Transport of Homogalacturonans. Biomacromolecules. 18(2), 505-516
[Journal article]Authored by: Williams, M.
Griffiths, MR., Raudsepp, A., McGrath, KM., & Williams, MAK. (2016). Measuring the interaction between a pair of emulsion droplets using dual-trap optical tweezers. RSC Advances. 6(18), 14538-14546
[Journal article]Authored by: Raudsepp, A., Williams, M.
Lian, J., Agban, Y., Cheong, S., Kuchel, RP., Raudsepp, A., Williams, MAK., . . . Prabakar, S. (2016). ZnO/PVP nanoparticles induce gelation in type I collagen. European Polymer Journal. 75, 399-405
[Journal article]Authored by: Raudsepp, A., Williams, M.
Raudsepp, A., Williams, MAK., & Hall, SB. (2016). Effects of non-Gaussian Brownian motion on direct force optical tweezers measurements of the electrostatic forces between pairs of colloidal particles. The European Physical Journal E - Soft Matter and Biological Physics. 39(7), 1-9 Retrieved from https://link.springer.com/article/10.1140/epje/i2016-16070-1
[Journal article]Authored by: Hall, S., Raudsepp, A., Williams, M.
Medini, K., Mansel, BW., Williams, MAK., Brimble, MA., Williams, DE., & Gerrard, JA. (2016). Controlling gelation with sequence: Towards programmable peptide hydrogels. Acta Biomaterialia. 43, 30-37
[Journal article]Authored by: Williams, M.
Hettiarachchi, CA., Melton, LD., Williams, MAK., McGillivray, DJ., Gerrard, JA., & Loveday, SM. (2016). Morphology of complexes formed between β-lactoglobulin nanofibrils and pectins is influenced by the pH and structural characteristics of the pectins. Biopolymers. , 819-831
[Journal article]Authored by: Loveday, S., Williams, M.
Raudsepp, A., Williams, MAK., & Hall, SB. (2016). Multidimensional mapping of the restoring force of an optical trap using triangular wave flow. Journal of Modern Optics. 63(21), 2308-2314
[Journal article]Authored by: Hall, S., Raudsepp, A., Williams, M.
Williams, MAK. (2016). Hey hey hey hey, it was the DNA. New Journal of Physics. 18(5)
[Journal article]Authored by: Williams, M.
Lian, J., Agban, Y., Cheong, S., Kuchel, RP., Raudsepp, A., Williams, MAK., . . . Prabakar, S. (2016). ZnO/PVP nanoparticles induce gelation in type i collagen. European Polymer Journal. 75, 399-405
[Journal article]Authored by: Williams, M.
Griffiths, MR., Raudsepp, A., McGrath, KM., & Williams, MAK. (2016). Measuring the interaction between a pair of emulsion droplets using dual-trap optical tweezers. RSC Advances. 6(18), 14538-14546
[Journal article]Authored by: Williams, M.
Yang, Z., Hemar, Y., Hilliou, L., Gilbert, EP., McGillivray, DJ., Williams, MAK., . . . Chaieb, S. (2016). Nonlinear Behavior of Gelatin Networks Reveals a Hierarchical Structure. Biomacromolecules. 17(2), 590-600
[Journal article]Authored by: Williams, M.
Kent, LM., Loo, TS., Melton, LD., Mercadante, D., Williams, MAK., & Jameson, GB. (2016). Structure and properties of a non-processive, salt-requiring, and acidophilic pectin methylesterase from aspergillus Niger provide insights into the key determinants of processivity control. Journal of Biological Chemistry. 291(3), 1289-1306
[Journal article]Authored by: Jameson, G., Williams, M.
Hettiarachchi, CA., Melton, LD., McGillivray, DJ., Loveday, SM., Gerrard, JA., & Williams, MAK. (2016). β-Lactoglobulin nanofibrils can be assembled into nanotapes via site-specific interactions with pectin. Soft Matter. 12(3), 756-768
[Journal article]Authored by: Loveday, S., Williams, M.
Suie, S., Raudsepp, A., Kent, LM., Keen, SAJ., Filichev, ., & Williams, MAK. (2015). DNA visualization in single molecule studies carried out with optical tweezers: Covalent versus non-covalent attachment of fluorophores. Biochemical and Biophysical Research Communications. 466(2), 226-231
[Journal article]Authored by: Filichev, V., Keen, S., Raudsepp, A., Williams, M.
Raudsepp, A., Griffiths, M., Sutherland-Smith, A., & Williams, MAK. (2015). Developing a video tracking method to study interactions between close pairs of optically trapped particles in three dimensions. Applied Optics. 54(32), 9370-9643 Retrieved from https://www.osapublishing.org/ao/issue.cfm?volume=54&issue=32
[Journal article]Authored by: Raudsepp, A., Sutherland-Smith, A., Williams, M.
Mansel, BW., Chu, CY., Leis, A., Hemar, Y., Chen, HL., Lundin, L., . . . Williams, MAK. (2015). Zooming in: Structural Investigations of Rheologically Characterized Hydrogen-Bonded Low-Methoxyl Pectin Networks. Biomacromolecules. 16(10), 3209-3216
[Journal article]Authored by: Williams, M.
Raudsepp, A., Griffiths, M., Sutherland-Smith, AJ., & Williams, AAK. (2015). Developing a video tracking method to study interactions between close pairs of optically trapped particles in three dimensions. APPLIED OPTICS. 54(32), 9518-9527
[Journal article]Authored by: Sutherland-Smith, A., Williams, M.
Suei, S., Raudsepp, A., Kent, LM., Keen, SAJ., Filichev, VV., & Williams, MAK. (2015). DNA visualization in single molecule studies carried out with optical tweezers: Covalent versus non-covalent attachment of fluorophores. Biochemical and Biophysical Research Communications. 466(2), 226-231
[Journal article]Authored by: Filichev, V., Keen, S., Williams, M.
Xu, AY., Melton, LD., Jameson, GB., Williams, MAK., & McGillivray, DJ. (2015). Structural mechanism of complex assemblies: Characterisation of beta-lactoglobulin and pectin interactions. Soft Matter. 11(34), 6790-6799
[Journal article]Authored by: Jameson, G., Williams, M.
Mansel, BW., & Williams, MAK. (2015). Internal stress drives slow glassy dynamics and quake-like behaviour in ionotropic pectin gels. Soft Matter. 11(35), 7016-7023
[Journal article]Authored by: Williams, M.
Kuczera, S., Perge, C., Fardin, MA., Brox, TI., Williams, MAK., Manneville, S., . . . Galvosas, P. (2015). Anomalous shear banding revisited with Rheo-NMR and Rheo-USV. Rheologica Acta. 54(7), 619-636
[Journal article]Authored by: Williams, M.
Kuczera, S., Perge, C., Fardin, M-A., Brox, TI., Williams, MAK., Manneville, S., . . . Galvosas, P. (2015). Anomalous shear banding revisited with Rheo-NMR and Rheo-USV. Rheologica Acta.
[Journal article]Authored by: Williams, M.
Lepper, CP., Williams, MAK., Edwards, PJ., & Jameson, GB. (2014). The effects of high pressure and pH on the hydrolysis of cytosine at high temperature. Chemistry in New Zealand. 78(3), 122-125 Retrieved from https://nzic.org.nz/
[Journal article]Authored by: Edwards, P., Jameson, G., Williams, M.
Yuliarti, O., Matia-Merino, L., Goh, KKT., Mawson, J., Williams, MAK., & Brennan, C. (2015). Characterization of gold kiwifruit pectin from fruit of different maturities and extraction methods. Food Chemistry. 166, 479-485
[Journal article]Authored by: Goh, K., Matia-Merino, M., Williams, M.
Lim, YF., Lentle, RG., Janssen, PWM., Williams, MAK., De Loubens, C., Mansel, BW., . . . Chambers, P. (2014). Determination of villous rigidity in the distal ileum of the possum (Trichosurus vulpecula). PLoS ONE. 9(6)
[Journal article]Authored by: Janssen, P., Lentle, R., Williams, M.
Raudsepp, A., Sutherland-Smith, AJ., & Williams, MAK. (2014). Rotating angled plate diffusing wave spectroscopy. International Journal of Nanotechnology. 11(5-8), 573-582
[Journal article]Authored by: Sutherland-Smith, A., Williams, M.
Kim, Y., Williams, MAK., Tzen, JTC., Luzio, GA., Galant, AL., & Cameron, RG. (2014). Characterization of charged functional domains introduced into a modified pectic homogalacturonan by an acidic plant pectin methylesterase (Ficus awkeotsang Makino) and modeling of enzyme mode of action. Food Hydrocolloids. 39, 319-329
[Journal article]Authored by: Williams, M.
Mercadante, D., Melton, LD., Jameson, GB., & Williams, MAK. (2014). Processive pectin methylesterases: The role of electrostatic potential, breathing motions and bond cleavage in the rectification of brownian motions. PLoS ONE. 9(2)
[Journal article]Authored by: Jameson, G., Williams, M.
Sasso, L., Suei, S., Domigan, L., Healy, J., Nock, V., Williams, MAK., . . . Gerrard, JA. (2014). Versatile multi-functionalization of protein nanofibrils for biosensor applications. Nanoscale. 6(3), 1629-1634
[Journal article]Authored by: Williams, M.
Fischer, J., Hall, JD., Patty, PJ., Williams, MAK., Waterland, MR., & Telfer, SG. (2013). Stereoselective aggregation of chiral complexes with threefold-symmetric pendant carboxyl groups: An example of "perfect" self-assembly not seen in the crystalline state?. RSC Advances. 3(31), 12648-12654
[Journal article]Authored by: Waterland, M., Williams, M.
Mercadante, D., Melton, LD., Jameson, GB., Williams, MAK., & De Simone, A. (2013). Substrate dynamics in enzyme action: Rotations of monosaccharide subunits in the binding groove are essential for pectin methylesterase processivity. Biophysical Journal. 104(8), 1731-1739
[Journal article]Authored by: Jameson, G., Williams, M.
Kim, Y., Williams, MAK., Galant, AL., Luzio, GA., Savary, BJ., Vasu, P., . . . Cameron, RG. (2013). Nanostructural modification of a model homogalacturonan with a novel pectin methylesterase: Effects of pH on nanostructure, enzyme mode of action and substrate functionality. Food Hydrocolloids. 33(1), 132-141
[Journal article]Authored by: Williams, M.
Al-Ghobashy, MA., Williams, MAK., Laible, G., & Harding, DRK. (2013). Coupled solid phase extraction and microparticle-based stability and purity-indicating immunosensor for the determination of recombinant human myelin basic protein in transgenic milk. Talanta. 109, 7-12
[Journal article]Authored by: Harding, D., Williams, M.
Vincent, RRR., Mansel, BW., Kramer, A., Kroy, K., & Williams, MAK. (2013). Micro-rheological behaviour and nonlinear rheology of networks assembled from polysaccharides from the plant cell wall. New Journal of Physics. 15
[Journal article]Authored by: Williams, M.
Lim, YF., Williams, MAK., Lentle, RG., Janssen, PWM., Mansel, BW., Keen, SAJ., . . . Chambers, P. (2013). An exploration of the microrheological environment around the distal ileal villi and proximal colonic mucosa of the possum (Trichosurus vulpecula). Journal of the Royal Society Interface. 10(81)
[Journal article]Authored by: Janssen, P., Keen, S., Lentle, R., Williams, M.
Mercadante, D., Melton, LD., Norris, GE., Loo, TS., Williams, MAK., Dobson, RCJ., . . . Jameson, GB. (2012). Bovine β-lactoglobulin is dimeric under imitative physiological conditions: Dissociation equilibrium and rate constants over the pH range of 2.5-7.5. Biophysical Journal. 103(2), 303-312
[Journal article]Authored by: Jameson, G., Norris, G., Williams, M.
Schuster, E., Lundin, L., & Williams, MAK. (2012). Investigating the relationship between network mechanics and single-chain extension using biomimetic polysaccharide gels. Macromolecules. 45(11), 4863-4869
[Journal article]Authored by: Williams, M.
Ralet, MC., Williams, MAK., Tanhatan-Nasseri, A., Ropartz, D., Quéméner, B., & Bonnin, E. (2012). Innovative enzymatic approach to resolve homogalacturonans based on their methylesterification pattern. Biomacromolecules. 13(5), 1615-1624
[Journal article]Authored by: Williams, M.
Fellah, A., Belmiloud, N., Haverkamp, RG., Hemar, Y., Otter, D., & Williams, MAK. (2012). Facilitating high-force single-polysaccharide stretching using covalent attachment of one end of the chain. Carbohydrate Polymers. 87(1), 806-815
[Journal article]Authored by: Haverkamp, R., Williams, M.
Piripi, SA., Williams, MAK., & Thompson, KG. (2011). On the sulfation pattern of polysaccharides in the extracellular matrix of sheep with chondrodysplasia. Cartilage. 2(1), 36-39
[Journal article]Authored by: Williams, M.
Belmiloud, N., Fellah, A., Haverkamp, RG., & Williams, MAK. (2011). Facilitating nanomechanical measurements on physisorbed biopolymers with automated on-the-fly monitoring of single-molecule force curves. Advanced Science Letters. 4(11-12), 3576-3579
[Journal article]Authored by: Haverkamp, R., Williams, M.
Lepper, C., Edwards, PJB., Dykstra, R., & Williams, MAK. (2011). Rheo-NMR studies of a nematic worm-like micelle system in a high-shear-rate regime. Soft Matter. 7(21), 10291-10298
[Journal article]Authored by: Edwards, P., Williams, M.
Cameron, RG., Luzio, GA., Kim, Y., Vasu, P., Savary, BJ., & Williams, MAK. (2011). Characterization of nanostructural modifications introduced into a model pectic homogalacturonan by esterases or chemical saponification and modeling of enzyme mode of action. Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011. 3, 275-278
[Journal article]Authored by: Williams, M.
Lepper, C., Edwards, PJB., Dykstra, R., & Williams, MAK. (2011). Rheo-NMR studies of a nematic worm-like micelle system in a high-shear-rate regime. SOFT MATTER. 7(21), 10291-10298
[Journal article]Authored by: Edwards, P., Williams, M.
Schuster, E., Cucheval, A., Lundin, L., & Williams, MAK. (2011). Using SAXS to reveal the degree of bundling in the polysaccharide junction zones of microrheologically distinct pectin gels. Biomacromolecules. 12(7), 2583-2590
[Journal article]Authored by: Williams, M.
Fellah, A., Anjukandi, P., Hemar, Y., Otter, D., & Williams, MAK. (2011). Towards polysaccharide handles for single molecule experiments: Spectroscopic evidence for the selective covalent coupling of terminal sugar residues to desired substrates. Carbohydrate Polymers. 86(1), 105-111
[Journal article]Authored by: Williams, M.
Al-Ghobashy, MA., Williams, MAK., Laible, G., & Harding, DRK. (2011). CZE with on-line micellar sample stacking for determination of protein concentration of biopharmaceuticals. Chromatographia. 73(11-12), 1145-1153
[Journal article]Authored by: Harding, D., Williams, M.
Cameron, RG., Luzio, GA., Vasu, P., Savary, BJ., & Williams, MAK. (2011). Enzymatic modification of a model homogalacturonan with the thermally tolerant pectin methylesterase from citrus: 1. Nanostructural characterization, enzyme mode of action, and effect of pH. Journal of Agricultural and Food Chemistry. 59(6), 2717-2724
[Journal article]Authored by: Williams, M.
Otter, CA., Patty, PJ., Williams, MAK., Waterland, MR., & Telfer, SG. (2011). Mechanically interlocked gold and silver nanoparticles using metallosupramolecular catenane chemistry. Nanoscale. 3(3), 941-944
[Journal article]Authored by: Waterland, M., Williams, M.
Belmiloud, N., Fellah, A., Haverkamp, RG., & Williams, MAK. (2011). Facilitating nanomechanical measurements on physisorbed biopolymers with automated on-the-fly monitoring of single-molecule force curves. Advanced Science Letters. 4(11-12), 3576-3579
[Journal article]Authored by: Haverkamp, R., Williams, M.
Piripi, SA., Williams, MAK., & Thompson, KG. (2011). On the sulfation pattern of polysaccharides in the extracellular matrix of sheep with chondrodysplasia. Cartilage. 2(1), 36-39
[Journal article]Authored by: Williams, M.
Schuster, E., Lundin, L., & Williams, MAK. (2010). Insights into the potential functionality of single-chain force-induced conformational transitions in polymer networks: implications for polysaccharide signaling in the plant cell wall.. Phys Rev E Stat Nonlin Soft Matter Phys. 82(5 Pt 1), 051927
[Journal article]Authored by: Williams, M.
Lepper, C., Edwards, PJB., Schuster, E., Brown, JR., Dykstra, R., Callaghan, PT., . . . Williams, MAK. (2010). Rheo-NMR studies of the behavior of a nematic liquid crystal in a low-shear-rate regime: the transition from director alignment to reorientation.. Phys Rev E Stat Nonlin Soft Matter Phys. 82(4 Pt 1), 041712
[Journal article]Authored by: Edwards, P., Williams, M.
Lepper, C., Edwards, PJB., Schuster, E., Brown, JR., Dykstra, R., Callaghan, PT., . . . Williams, MAK. (2010). Rheo-NMR studies of the behavior of a nematic liquid crystal in a low-shear-rate regime: The transition from director alignment to reorientation. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 82(4)
[Journal article]Authored by: Edwards, P., Williams, M.
Schuster, E., Lundin, L., & Williams, MAK. (2010). Insights into the potential functionality of single-chain force-induced conformational transitions in polymer networks: Implications for polysaccharide signaling in the plant cell wall. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 82(5)
[Journal article]Authored by: Williams, M.
Williams, MAK., Cucheval, A., Nasseri, AT., & Ralet, MC. (2010). Extracting intramolecular sequence information from intermolecular distributions: Highly nonrandom methylester substitution patterns in homogalacturonans generated by pectinmethylesterase. Biomacromolecules. 11(6), 1667-1675
[Journal article]Authored by: Williams, M.
Anjukandi, P., Pereira, GG., & Williams, MAK. (2010). Langevin dynamics simulations reveal biologically relevant folds arising from the incorporation of a torsional potential. Journal of Theoretical Biology. 265(3), 245-249
[Journal article]Authored by: Williams, M.
Al-Ghobashy, MA., Cucheval, A., Williams, MAK., Laible, G., & Harding, DRK. (2010). Probing the interaction between recombinant human myelin basic protein and caseins using surface plasmon resonance and diffusing wave spectroscopy. Journal of Molecular Recognition. 23(1), 84-92
[Journal article]Authored by: Harding, D., Williams, M.
Hoang, VC., Williams, MAK., & Simpson, HV. (2010). Effects of weaning and infection with Teladorsagia circumcincta on mucin carbohydrate profiles of early weaned lambs. Veterinary Parasitology. 171(3-4), 354-360
[Journal article]Authored by: Williams, M.
Hoang, VC., Williams, MAK., & Simpson, HV. (2010). Monosaccharide composition of fundic and duodenal mucins in sheep infected with Haemonchus contortus or Teladorsagia circumcincta. VETERINARY PARASITOLOGY. 170(3-4), 253-261
[Journal article]Authored by: Williams, M.
Edwards, PJB., Kakubayashi, M., Dykstra, R., Pascals, SM., & Williams, MAK. (2010). Rheo-NMR studies of an enzymatic reaction: Evidence of a shear-stable macromolecular system. Biophysical Journal. 98(9), 1986-1994
[Journal article]Authored by: Edwards, P., Williams, M.
Hoang, VC., Williams, MAK., & Simpson, HV. (2010). Monosaccharide composition of fundic and duodenal mucins in sheep infected with Haemonchus contortus or Teladorsagia circumcincta. Veterinary Parasitology. 170(3-4), 253-261
[Journal article]Authored by: Williams, M.
Cucheval, ASB., Vincent, RR., Hemar, Y., And, DO., & Williams, MAK. (2009). Multiple particle tracking investigations of acid milk gels using tracer particles with designed surface chemistries and comparison with diffusing wave spectroscopy studies. Langmuir. 25(19), 11827-11834
[Journal article]Authored by: Williams, M.
Vincent, RR., & Williams, MAK. (2009). Microrheological investigations give insights into the microstructure and functionality of pectin gels. Carbohydrate Research. 344(14), 1863-1871
[Journal article]Authored by: Williams, M.
Cucheval, A., Al-Ghobashy, MA., Hemar, Y., Otter, D., & Williams, MAK. (2009). Direct measurements of interfacial interactions between pectin and κ-casein and implications for the stabilisation of calcium-free casein micelle mimics. Journal of Colloid and Interface Science. 338(2), 450-462
[Journal article]Authored by: Williams, M.
Cucheval, A., Vincent, RR., Hemar, Y., Otter, D., & Williams, MAK. (2009). Diffusing wave spectroscopy investigations of acid milk gels containing pectin. Colloid and Polymer Science. 287(6), 695-704
[Journal article]Authored by: Williams, M.
Williams, MAK., Cucheval, A., Ström, A., & Ralet, MC. (2009). Electrophoretic behavior of copolymeric galacturonans including comments on the information content of the intermolecular charge distribution. Biomacromolecules. 10(6), 1523-1531
[Journal article]Authored by: Williams, M.
Al-Ghobashy, MA., Williams, MAK., Brophy, B., Laible, G., & Harding, DRK. (2009). On-line casein micelle disruption for downstream purification of recombinant human myelin basic protein produced in the milk of transgenic cows. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 877(16-17), 1667-1677
[Journal article]Authored by: Harding, D., Williams, M.
Vincent, RR., Cucheval, A., Hemar, Y., & Williams, MAK. (2009). Bio-inspired network optimization in soft materials - Insights from the plant cell wall. European Physical Journal E. 28(1), 79-87
[Journal article]Authored by: Williams, M.
Fellah, A., Anjukandi, P., Waterland, MR., & Williams, MAK. (2009). Determining the degree of methylesterification of pectin by ATR/FT-IR: Methodology optimisation and comparison with theoretical calculations. Carbohydrate Polymers. 78(4), 847-853
[Journal article]Authored by: Waterland, M., Williams, M.
Cameron, RG., Luzio, GA., Goodner, K., & Williams, MAK. (2008). Demethylation of a model homogalacturonan with a citrus salt-independent pectin methylesterase: Effect of pH on block size and number. Enzyme mode of action and resulting functionality. Gums and Stabilisers for the Food Industry 14. , 141-152
[Journal article]Authored by: Williams, M.
Al-Ghobashy, MA., Williams, MAK., & Harding, DRK. (2008). Factors affecting the performance of capillary isoelectric focusing in dynamically coated capillaries using polyethylene oxide polymer. Analytical Letters. 41(10), 1914-1931
[Journal article]Authored by: Harding, D., Williams, M.
Williams, MAK., Vincent, RR., Pinder, DN., & Hemar, Y. (2008). Microrheological studies offer insights into polysaccharide gels. Journal of Non-Newtonian Fluid Mechanics. 149(1-3), 63-70
[Journal article]Authored by: Williams, M.
Cameron, RG., Luzio, GA., Goodner, K., & Williams, MAK. (2008). Demethylation of a model homogalacturonan with a salt-independent pectin methylesterase from citrus: I. Effect of pH on demethylated block size, block number and enzyme mode of action. Carbohydrate Polymers. 71(2), 287-299
[Journal article]Authored by: Williams, M.
Williams, MAK., Marshall, A., Haverkamp, RG., & Draget, KI. (2008). Stretching single polysaccharide molecules using AFM: A potential method for the investigation of the intermolecular uronate distribution of alginate?. Food Hydrocolloids. 22(1), 18-23
[Journal article]Authored by: Haverkamp, R., Williams, M.
Vincent, RR., Pinder, DN., Hemar, Y., & Williams, MAK. (2007). Microrheological studies reveal semiflexible networks in gels of a ubiquitous cell wall polysaccharide.. Phys Rev E Stat Nonlin Soft Matter Phys. 76(3 Pt 1), 031909
[Journal article]Authored by: Williams, M.
Williams, MAK., Marshall, AT., Anjukandi, P., & Haverkamp, RG. (2007). Investigation of the effects of fine structure on the nanomechanical properties of pectin.. Phys Rev E Stat Nonlin Soft Matter Phys. 76(2 Pt 1), 021927
[Journal article]Authored by: Haverkamp, R., Williams, M.
Haverkamp, RG., Marshall, AT., & Williams, MAK. (2007). Model for stretching elastic biopolymers which exhibit conformational transformations.. Phys Rev E Stat Nonlin Soft Matter Phys. 75(2 Pt 1), 021907
[Journal article]Authored by: Haverkamp, R., Williams, M.
Ström, A., Ribelles, P., Lundin, L., Norton, I., Morris, ER., & Williams, MAK. (2007). Influence of pectin fine structure on the mechanical properties of calcium-pectin and acid-pectin gels. Biomacromolecules. 8(9), 2668-2674
[Journal article]Authored by: Williams, M.
Vincent, RR., Pinder, DN., Hemar, Y., & Williams, MAK. (2007). Microrheological studies reveal semiflexible networks in gels of a ubiquitous cell wall polysaccharide. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 76(3)
[Journal article]Authored by: Williams, M.
Noisuwan, A., Hemar, Y., Bronlund, JE., Wilkinson, B., & Williams, MAK. (2007). Viscosity, swelling and starch leaching during the early stages of pasting of normal and waxy rice starch suspensions containing different milk protein ingredients. Starch/Staerke. 59(8), 379-387
[Journal article]Authored by: Bronlund, J., Wilkinson, B., Williams, M.
Haverkamp, RG., Marshall, AT., & Williams, MAK. (2007). Entropic and enthalpic contributions to the chair-boat conformational transformation in dextran under single molecule stretching. Journal of Physical Chemistry B. 111(48), 13653-13657
[Journal article]Authored by: Haverkamp, R., Williams, M.
Williams, MAK., Marshall, AT., Anjukandi, P., & Haverkamp, RG. (2007). Investigation of the effects of fine structure on the nanomechanical properties of pectin. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 76(2)
[Journal article]Authored by: Haverkamp, R., Williams, M.
Haverkamp, RG., Marshall, AT., & Williams, MAK. (2007). Model for stretching elastic biopolymers which exhibit conformational transformations. Physical Review E - Statistical, Nonlinear, and Soft Matter Physics. 75(2)
[Journal article]Authored by: Haverkamp, R., Williams, M.
Goubet, F., Strom, A., Quemener, B., Stephens, E., Williams, MA., & Dupree, P. (2006). Resolution of the structural isomers of partially methylesterified oligogalacturonides by polysaccharide analysis using carbohydrate gel electrophoresis. Glycobiology. 16(1), 29-35
[Journal article]Authored by: Williams, M.
Hunt, JJ., Cameron, R., & Williams, MAK. (2006). On the simulation of enzymatic digest patterns: The fragmentation of oligomeric and polymeric galacturonides by endo-polygalacturonase II. Biochimica et Biophysica Acta - General Subjects. 1760(11), 1696-1703
[Journal article]Authored by: Williams, M.
Goubet, F., Strom, A., Quemener, B., Stephens, E., Williams, MA., & Dupree, P. (2006). Resolution of the structural isomers of partially methylesterified oligogalacturonides by polysaccharide analysis using carbohydrate gel electrophoresis. Glycobiology. 16(1), 29-35
[Journal article]Authored by: Williams, M.
Haverkamp, RG., Williams, MAK., & Scott, JE. (2005). Stretching single molecules of connective tissue glycans to characterize their shape-maintaining elasticity. Biomacromolecules. 6(3), 1816-1818
[Journal article]Authored by: Haverkamp, R., Williams, M.
Williams, MA. (2005). Biomaterials. New Zealand Science Review. 62(1-2), 30-32
[Journal article]Authored by: Williams, M.
Ström, A., Ralet, MC., Thibault, JF., & Williams, MAK. (2005). Capillary electrophoresis of homogeneous pectin fractions. Carbohydrate Polymers. 60(4), 467-473
[Journal article]Authored by: Williams, M.
Goubet, F., Ström, A., Quéméner, B., Stephens, E., Williams, MAK., & Dupree, P. (2006). Resolution of the structural isomers of partially methylesterified oligogalacturonides by polysaccharide analysis using carbohydrate gel electrophoresis. Glycobiology. 16(1), 29-35
[Journal article]Authored by: Williams, M.
Goubet, F., Ström, A., Dupree, P., & Williams, MAK. (2005). An investigation of pectin methylesterification patterns by two independent methods: Capillary electrophoresis and polysaccharide analysis using carbohydrate gel electrophoresis. Carbohydrate Research. 340(6), 1193-1199
[Journal article]Authored by: Williams, M.
Fabri, D., Williams, MAK., & Halstead, TK. (2005). Water T<inf>2</inf> relaxation in sugar solutions. Carbohydrate Research. 340(5), 889-905
[Journal article]Authored by: Williams, M.
Ström, A., & Williams, MAK. (2004). On the separation, detection and quantification of pectin derived oligosaccharides by capillary electrophoresis. Carbohydrate Research. 339(10), 1711-1716
[Journal article]Authored by: Williams, M.
Strom, A., & Williams, MA. (2003). Controlled calcium release in the absence and presence of an ion-binding polymer. Journal of Physical Chemistry B. 107(40), 10995-10999
[Journal article]Authored by: Williams, M.
Williams, MA., Foster, TJ., & Schols, HA. (2003). Elucidation of pectin methylester distributions by capillary electrophoresis. Journal of Agricultural and Food Chemistry. 51(7), 1777-1781
[Journal article]Authored by: Williams, M.
Zhang, H., Nishinari, K., Williams, MA., Foster, TJ., & Norton, IT. (2002). A molecular description of the gelation mechanism of curdlan. International Journal of Biological Macromolecules. 30(1), 7-16
[Journal article]Authored by: Williams, M.
Williams, MA., Buffet, G., & Foster, T. (2002). Analysis of partially methyl-esterified galacturonic acid oligomers by capillary electrophoresis. Analytical Biochemistry. 301(1), 117-122
[Journal article]Authored by: Williams, M.
Williams, MA., & Benen, J. (2002). A novel enzyme activity involving the demethylation of specific partially methylated oligogalacturonides. Biochemical Journal. 367(2), 511-515
[Journal article]Authored by: Williams, M.
Loren, N., Hermansson, A., Williams, MA., Lundin, L., Foster, T., Hubbard, CD., . . . Goodall, DM. (2001). Phase separation induced by conformational ordering of gelatin in gelatin/maltodextrin mixtures. Macromolecules. 34(2), 289-297
[Journal article]Authored by: Williams, M.
Zhang, H., Yoshimura, M., Nishinari, K., Williams, MA., Foster, T., & Norton, IT. (2001). Gelation behaviour of konjac glucomannan with different molecular weights. Biopolymers. 59(1), 38-50
[Journal article]Authored by: Williams, M.
Williams, MA., Fabri, D., Hubbard, CD., Lundin, L., Foster, TJ., Clark, AH., . . . Hermansson, A. (2001). Kinetics of droplet growth in gelatin/maltodextrin mixtures following thermal quenching. Langmuir. 17(11), 3412-3418
[Journal article]Authored by: Williams, M.
Williams, MA., Buffet, G., Foster, T., & Norton, IT. (2001). Simulation of endo-PG digest patterns and implications for the determination of pectin fine structure. Carbohydrate Research. 334(3), 243-250
[Journal article]Authored by: Williams, M.
Williams, MA., Fabri, D., Halstead, TK., & Hubbard, CD. (2001). Versatile thermoelectric devices for precise, rapid, or slow heating or cooling of samples: UV-VIS and NMR spectroscopic applications. Instrumentation Science and Technology. 29(5), 367-382
[Journal article]Authored by: Williams, M.
Aymard, P., Williams, MA., Clark, AH., & Norton, IT. (2000). A turbidimetric study of phase separating biopolymer mixtures during thermal ramping. Langmuir. 16(19), 7383-7391
[Journal article]Authored by: Williams, M.
Williams, MA., Foster, T., Martin, DR., Norton, IT., Yoshimura, M., & Nishinari, K. (2000). A molecular description of the gelation mechanism of konjac mannan. Biomacromolecules. 1(3), 440-450
[Journal article]Authored by: Williams, M.

Book

Lundin, L., Williams, MA., & Foster, MA. (2003). Phase separation in foods. In BMM. Ed (Ed.) Texture in food: Volume 1: Semi-solid food. (pp. 63 - 85). Cambridge, UK: Woodhead Publishing
[Chapter]Authored by: Williams, M.
Williams, MA., Buffet, G., & Foster, T. (2002). Capillary electrophoresis as a tool for the characterisation of pectin fine structure. In PA. Williams, & GOP. Eds (Eds.) Gums and stabilisers for the food industry 11. (pp. 13 - 26). Cambridge, UK: The Royal Society of Chemistry
[Chapter]Authored by: Williams, M.

Creative Work

Williams, MA.(2005). Why we are all big softies. [online]. Auckland, NZ: e=mc2: The Story of the Universe
[Film or Video]Authored by: Williams, M.

Report

Sutherland-Smith, AJ., Raudsepp, A., Robertson, SP., & williams, MAK. (2014). RSNZ Marsden Grant Report; Stretching protein springs: How do cells respond to force?.
[Commissioned Report]Authored by: Raudsepp, A., Sutherland-Smith, A., Williams, M.

Conference

Raudsepp, A., Suei, S., Sutherland-Smith, AJ., & Williams, M. (2014). Three Dimensional Force Spectroscopy of a Single Extended DNA Molecule. Poster session presented at the meeting of 2014 Biophysical Congress. Brisbane, Australia
[Conference Poster]Authored by: Raudsepp, A., Sutherland-Smith, A., Williams, M.
Raudsepp, A., Sutherland-Smith, A., & Williams, M.(2014). Rotating angled plate diffusing wave spectroscopy. Paper presented at the meeting of International Journal of Nanotechnology. University of Auckland, New Zealand
[Conference Paper]Authored by: Raudsepp, A., Sutherland-Smith, A., Williams, M.
Munro, BC., Edwards, PJB., Williams, MAK., & Dykstra, R. (2013). Investigation into new methods for Residual Dipolar Coupling aided structural determination of a small organic molecule. Poster session presented at the meeting of New Zealand Institute of Chemistry Conference. Victoria Univeristy, Wellington, New Zealand
[Conference Poster]Authored by: Edwards, P., Williams, M.
Mansel, B., Raudsepp, A., Sutherland-Smith, AJ., & Williams, MAK. (2013). An investigation of heterogeneity in biogels using multiple particle tracking. Poster session presented at the meeting of Sixth International Conference on Advance Materials and Nanotechnology
[Conference Poster]Authored by: Raudsepp, A., Sutherland-Smith, A., Williams, M.
Hoang, VC., Simpson, HV., Williams, MAK., & Simcock, DC.Effects of parasitism on gastrointestinal mucins of sheep.
[Conference Oral Presentation]Authored by: Williams, M.
Haverkamp, RG., Marshall, AT., & Williams, MAK. (2007). The thermodynamics of single molecule stretching of polysaccharides: Implications for elastic tissues. In AIChE Annual Meeting, Conference Proceedings
[Conference Abstract]Authored by: Haverkamp, R., Williams, M.
Williams, MA., Vincent, RR., Pinder, DN., & Hemar, Y. (2007, February). Micro-rheological studies of biopolymer networks with Multiple Particle Tracking. Presented at 3rd International Conference on Advanced Materials and Nanotechnology (AMN-3). Wellington, NZ.
[Conference Oral Presentation]Authored by: Williams, M.
Williams, MA., Vincent, RR., Pinder, DN., & Hemar, Y. (2006, June). Micro-rheological studies with multiple particle tracking. Presented at International Workshop on Mesoscale and Multiscale Description of Complex Fluids. Monash University Centre, Prato, Italy.
[Conference Oral Presentation]Authored by: Williams, M.
Haverkamp, RG., Marshall, AT., & Williams, MA. (2006). Single molecule polysaccharide stretching: A model for the conformational transformations. In Proceedings of the World Polymer Congress: 41st International Symposium on Macromolecules: Brazilian Polymer Association
[Conference Abstract]Authored by: Haverkamp, R., Williams, M.
Williams, MA., Haverkamp, RG., Marshall, AT., & Draget, KI. (2006). Stretching single polysaccharide molecules using AFM: A potential method for the investigation of the intermolecular uronate distribution of alginate?. In 8th International Hydrocolloids Conference: Norwegian University of Science and Technology
[Conference Abstract]Authored by: Haverkamp, R., Williams, M.
Marshall, AT., Haverkamp, RG., & Williams, MA. (2006). Stretching single molecules of pectin and their force induced conformational transformations. In Back to the Basics: From Small Molecules to Materials and Surfaces: Proceedings of the New Zealand Institute of Chemistry (NZIC) 2006 Conference(pp. 151 - 152). : New Zealand Institute of Chemistry
[Conference Abstract]Authored by: Haverkamp, R., Williams, M.
Williams, BA., Haverkamp, RG., & Scott, JE. (2005, February). Stretching single polysaccharide molecules using AFM. Presented at Second International Conference on Advanced Materials and Nanotechnology. Queenstown, NZ.
[Conference Oral Presentation]Authored by: Haverkamp, R., Williams, M.
Williams, MA., Haverkamp, RG., & Scott, JE. (2005). Stretching single molecules of connective tissue glycans using AFM. Poster session presented at the meeting of 1st International Conference on Mechanics of Biomaterials and Tissues. Waikoloa, HI
[Conference Poster]Authored by: Haverkamp, R., Williams, M.
Williams, MA. (2004, October). Stretching single biopolymers. Presented at MacDiarmid Institute Video-Conference Seminar. Massey University, Palmerston North, NZ.
[Conference Oral Presentation]Authored by: Williams, M.
Williams, MA. (2004, August). Perspectives on polysaccharide sequencing. Presented at 7th International Hydrocolloids Conference. Melbourne, VIC.
[Conference Oral Presentation]Authored by: Williams, M.
Strom, A., Schumm, S., & Williams, MA. (2003). DE determination of pectins using ATR/FT-IR and capillary electrophoresis. Poster session presented at the meeting of 12th Gums and Stabilisers for the Food Industry Conference. North East Wales Institute, Wrexham, UK
[Conference Poster]Authored by: Williams, M.
Williams, MA. (2003, July). Sugar and spice adventures in polysaccharide biophysics. Presented at 11th New Zealand Institute of Physics National Conference 2003: Enhancing Physics. Massey University, Palmerston North, NZ.
[Conference Oral Presentation]Authored by: Williams, M.
Williams, MA. (2003, December). Biopolymer structure: Function relationships. Presented at Food Colloids and Biopolymer: From Basic Theory to Practical Realities. Massey University, Palmerston North, NZ.
[Conference Oral Presentation]Authored by: Williams, M.
Haug, I., Williams, MA., Lundin, L., Smidsrod, O., & Draget, KI. (2003). Molecular interactions in, and rheological properties of, a mixed biopolymer system undergoing order/disorder transitions. Food Hydrocolloids. Vol. 17 (pp. 439 - 444). The Netherlands: 6th International Hydrocolloids Conference
[Conference Paper in Published Proceedings]Authored by: Williams, M.
Williams, MA., Foster, T., Russell, AL., & Norton, IT. (2000, September). The influence of solvent conditions on polysaccharide functionality. Presented at 5th International Hydrocolloids Conference: The Human-Hydrocolloid Interface. Raleigh, NC.
[Conference Oral Presentation]Authored by: Williams, M.
Zhang, H., Nishinari, K., Foster, TJ., Williams, MA., & Norton, IT. (2000). A study of the gelation of the polysaccharide curdlan. In Y. Iwasawa, N. Oyama, & HK. Eds (Eds.) Proceedings of the International Conference on Colloid and Surface Science. Vol. 132 (pp. 65 - 68). Amsterdam, The Netherlands
[Conference Paper in Published Proceedings]Authored by: Williams, M.

Other

Williams, MA. (2006). Picking up the pieces. In Food Science Australia. Presented at North Ryde, Sydney, NSW.
[Oral Presentation]Authored by: Williams, M.
Williams, MA. (2006, July). Interactive science and technology display. In Te Manawa Science Festival. Presented at Palmerston North, NZ.
[Oral Presentation]Authored by: Williams, M.
Williams, MA. (2006, October). What is 'natural' anymore? and does anyone care?. In Science Cafe @ Te Manawa. Presented at Palmerston North, NZ.
[Oral Presentation]Authored by: Williams, M.
Williams, MA. (2006, December). Nature's nanotech: Designing soft materials from the bottom up. In Department of Chemical and Biomolecular Engineering. Presented at University of Melbourne, Melbourne, VIC.
[Oral Presentation]Authored by: Williams, M.
Williams, BA. (2005). Space: 2005 Te Manawa science festival. Te Manawa Museums Trust
[Other]Authored by: Williams, M.
Williams, MA. (2005). Ask-a-scientist question. Otago Daily Times
[Other]Authored by: Williams, M.
Williams, BA. (2004). Cool stuff. Click onto Sciences Day
[Other]Authored by: Williams, M.
Williams, BA. (2004). Why smashing things apart is only half the story. Manawatu Science Festival
[Other]Authored by: Williams, M.

Supervision and Teaching

Summary of Doctoral Supervision

Position Current Completed
Supervisor 5 7
CoSupervisor 1 3

Current Doctoral Supervision

Supervisor of:

  • Susav Pradhan - PhD
    investigating the application of controlled emulsion cell mimics for understanding cell mechanics
  • Sapna Ravindran - PhD
    Capture Probabilities in Pair-Wise Collisions of Emulsion Drops Measurement and Application
  • Amir Irani - PhD
    Computational Investigation of Local Counterion Condensation in Blocky Polyelectrolytes
  • Jessie Owen - PhD
    Biophysical approaches to elucidating structure-function relationships in polysaccharide co-polymer systems
  • Pablo Hernandez Cerdan - PhD
    Biopolymer networks: Image Analysis, Reconstruction and Modeling

CoSupervisor of:

  • Manohar Mulinti - PhD
    Effects of disease associated with FLNA mutation on cellular responses to varying shear forces and varying 3D polymer matrix stiffness surface patterns

Completed Doctoral Supervision

Supervisor of:

CoSupervisor of:

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