College of Sciences staff

Associate Professor Evelyn Sattlegger staff profile picture

Contact details +64 (09) 414 0800  ext. 43502

Associate Professor Evelyn Sattlegger

Associate Professor

Institute of Natural and Mathematical Sciences

more information can be found at http://www.sattlegger-lab.webs.com


Roles and Responsibilities

Research and Teaching

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Professional

Contact details

  • Ph: +64 (0)9 414 0800 extn 43502
    Location: 4, Building 14
    Campus: Albany

Qualifications

  • Vordiplom, equivalent to Bachelor of Science - Leibniz Uni., Medical & Veterin. School, Hannover (1988)
  • Diplom (Dist), Microb, Genetics, Biochem, Immunolo - Leibniz Uni., Medical & Veterin. School, Hannover (1992)
  • Doctor rerum naturalium, Molecular Biol & Genetics - Leibniz University Hannover (1996)

Research Expertise

Research Interests

Stress & starvation,

how do we (i.e. the cells in our body) respond and cope

Signal transduction mechanisms, and translational control

Using baker's yeast (Saccharomyces) as model organism for health related questions

Saccharomyces in Biotechnological applications

Techniques applied: Molecular Biology, Molecular Genetics, Genetics, Cell Biology, Biochemistry (protein purification, protein-protein/nucleic acid interactions, ribosomes, enzyme assays

Organisms: Saccharomyces cerevisiae (baker's or brewer's yeast), Neurospora crassa, Escherichia coli, cell culture

Thematics

21st Century Citizenship, Resource Development and Management, Health and Well-being, Future Food Systems

Area of Expertise

Field of research codes
Biochemistry and Cell Biology (060100): Biological Sciences (060000): Genetics (060400):
Medical And Health Sciences (110000):
Microbiology (060500): Other Biological Sciences (069900)

Keywords

yeast as model organism for biomedical investigations

molecular biology & genetics

Saccharomcyes cerevisae - baker's yeast

regulation of the protein Gcn2

Research Projects

Summary of Research Projects

Position Current Completed
Project Leader 3 19

Completed Projects

Project Title: How do we know that we are hungry? Unravelling the molecular basis of sensing amino acid starvation

Proper food selection is influenced not only by cultural and learning factors, but also by inherited factors. Two such factors, GCN2 and GCN1, are the focus of our work. GCN2 is an enzyme, and together with its effector protein GCN1, is essential for every eukaryotic cell to detect and cope with amino acid-starvation. Amino acids are particularly important nutrients because, as constituents of proteins, they execute almost all biological functions. GCN2 is also essential for further specialized processes such as developing aversion against amino acid-imbalanced food, long term memory formation, viral defence, and possibly silencing the immune system. Thus, GCN2 plays several pivotal roles in life, suggesting that GCN2-malfunction is implicated in associated diseases/disorders. GCN2¿s role in these various processes remains obscure, and GCN1-function has not been explored so far. In order to understand specialized processes involving GCN2, we first need to elucidate the universal cellular role of GCN2 and GCN1, i.e. sensing and signalling amino acid-hunger. We propose to unravel this GCN2/GCN1-function in molecular detail by using a simple eukaryotic model organism, baker¿s yeast, and following interdisciplinary approaches involving biochemistry, molecular biology, genetics, and cryo electron microscopy. Our research will pave the way to understanding the many specialized GCN2-functions.
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Date Range: 2007 - 2011

Funding Body: Royal Society of New Zealand

Project Team:

Project Title: Making an IMPACT on brain function

Studying the function of YIH1, the yeast homologue of the brain protein impact.
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Date Range: 2006 - 2010

Funding Body: Health Research Council of New Zealand

Project Team:

Consultancy and Languages

Languages

  • German
    Last used: - current
    Spoken ability: Excellent
    Written ability: Excellent
  • English
    Last used: - current
    Spoken ability: Excellent
    Written ability: Excellent

Supervision and Teaching

Summary of Doctoral Supervision

Position Current Completed
Supervisor 1 4
CoSupervisor 1 3

Teaching

Undergraduate papers:

122.101/221 - Biochemistry of Cells/Foods

122.233 - Metabolic Biochemistry (paper coordinator)

162.101 - Biology of Cells

203.340 - Applied Molecular Biology

Postgraduate papers:

122.703 - Gene expression (paper coordinator)

122.704 - Molecular Cell Biology (paper coordinator only)

162.760 - Research Methods (paper coordinator)

and other papers as required

Media and Links

Other Links


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