Janyawat Vuthijumnonk

Doctor of Philosophy, (Nutritional Science)
Study Completed: 2016
College of Health

Citation

Thesis Title
Biological properties of blueberries and their effects on breast cancer in DMBA - induced mammary tumorigenesis rat models

Read article at Massey Research Online: MRO icon

In New Zealand, breast cancer accounts for more than 20 percent of all registered cancers and has become the most expensive cancer to treat. For this reason, research into breast cancer prevention and alternative therapeutic approaches is very important. Ms Vuthijumnonk examined the biological properties of blueberries, a fruit rich in phytochemicals. An assay using fertilised eggs showed that blueberry extract inhibits new blood vessel formation which is an important factor in tumour growth. An animal study was conducted and showed that blueberry consumption, especially when fibre was included, reduced the number and size of induced tumours in rats. Data suggested this effect relied on decreasing oxidative stress, circulating estrogen concentration and ß-glucuronidase enzyme activity in blood. Her research findings suggest the population risk of breast cancer could be reduced through increased consumption of blueberries.

Supervisors
Professor Julian Heyes
Professor Abdul-Lateef Molan
Dr Fran Wolber
Dr Wei-Hang Chua

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