Mayank Saraswat

Doctor of Philosophy, (Biochemistry)
Study Completed: 2014
College of Sciences

Citation

Thesis Title
In search of novel folds:Protein evolution via non-homologous recombination

Read article at Massey Research Online: MRO icon

The emergence of proteins from short naturally occurring biological molecules or subdomains, made easier by the duplication and fusion of the minigenes encoding them, is believed to have played a role in the origin of life. Mr. Saraswat''saim was to randomly recombine short segments of two distantly related proteins, one from a rat and one from bacteria, to identify new folded structures, which may or may not resemble the parental structure. This was based on the theory that new domains or basic elements of protein structure may result from the same or similar recombinations of the genes coding for smaller subdomains. Mr Saraswat’s research led to the discovery of two joined proteins which widens the possibilities of exploring and expanding the protein structure space. It offers close encounters with these never born proteins that may be trapped in a unit of varying (structured and unstructured) states.

Supervisors
Associate Professor Jane Allison
Dr Wayne Patrick
Associate Professor Gill Norris

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