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Animal Cell Culture Technology

This research area focuses on design, development and scaleup of animal cell culture processes for producing  vaccines, monoclonal antibodies, biopharmaceuticals, and therapeutic proteins.  Insights gained through this work have been used in designing commercial processes for producing a variety of animal cell derived protein products.

Selected Publications

Chisti, Y., Crit. Rev. Biotechnol., 21, 67-110 (2001). Hydrodynamic damage to animal cells. [Reprint PDF]

Chisti, Y., Trends Biotechnol., 18, 420-432 (2000). Animal-cell damage in sparged bioreactors. [Reprint PDF]

Chisti, Y., in Encyclopedia of Food Microbiology, Robinson, R., Batt, C., and Patel, P., editors, Academic Press, London, 1999, pp. 1806-1815. Modern systems of plant cleaning. [Reprint PDF]

Rouf, S. A., Moo-Young, M., and Chisti, Y., Biotechnol. Adv., 14, 239-266 (1996). Tissue-type plasminogen activator: Characteristics, applications and production technology. [Reprint PDF]

Zhang, Z., Chisti, Y., and Moo-Young, M., J. Biotechnol., 43, 33-40 (1995). Effects of the hydrodynamic environment and shear protectants on survival of erythrocytes in suspension. [Reprint PDF]

Chisti, Y., Bioprocess Eng., 9, 191-196 (1993); Process Biochem., 28, 511-517 (1993). Animal cell culture in stirred bioreactors: Observations on scale-up. 

Moo-Young, M. and Chisti, Y., Biotechnology, 6(11), 1291-1296 (1988). Considerations for designing bioreactors for shear-sensitive culture.


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