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Microalgal Biotechnology and Marine Bioactives

Marine microalgae, cyanobacteria, sponges and other invertebrates are sources and potential sources of novel substances including anticancer drugs and other therapeutics. This research area focuses on bioprospecting for novel compounds from marine sources; development of technologies for large scale production of microalgae, marine bacteria and sponges as sources of useful products; methods for recovery and purification of target products; and assessment of bioactivity of target compounds.




Image courtesy of National Oceanic and Atmospheric Administration/Department of Commerce

Selected Publications

Grima, E. M., Fernández, F. G. A., Camacho, F. G., Chisti, Y., J. Biotechnol., 70, 231-247 (1999). Photobioreactors: light regime, mass transfer, and scaleup. [Reprint PDF]

Belarbi, E. H., Molina, E., Chisti, Y., Enzyme Microb. Technol., 26, 516-529 (2000). A process for high yield and scaleable recovery of high purity eicosapentaenoic acid esters from microalgae and fish oil. [Reprint PDF]

Chisti, Y., Biotechnol. Adv., 18, 547-548 (2000). Marine biotechnology—a neglected resource (editorial).

García Camacho, F., Molina Grima, E., Sánchez Mirón, A., González Pascual, V., Chisti, Y., Enzyme Microb. Technol., 29, 602-610 (2001). Carboxymethyl cellulose protects algal cells against hydrodynamic stress. [Reprint PDF]

Acién Fernández, F. G., Fernández Sevilla, J. M., Sánchez Pérez, J. A., Molina Grima, E., Chisti, Y., Chem. Eng. Sci., 56, 2721-2732 (2001). Airlift-driven external-loop tubular photobioreactors for outdoor production of microalgae: assessment of design and performance. [Reprint PDF]

Molina, E., Fernández, J., Acién, F. G., Chisti, Y., J. Biotechnol., 92, 113-131 (2001). Tubular photobioreactor design for algal cultures. [Reprint PDF]

Sánchez Mirón A, Cerón García M-C, Contreras Gómez A, García Camacho F, Molina Grima E, Chisti Y. Biochem. Eng. J., 16, 287–297 (2003). Shear stress tolerance and biochemical characterization of Phaeodactylum tricornutum in quasi steady-state continuous culture in outdoor photobioreactors. [Reprint PDF]

Belarbi, E. H., Gomez, A. C., Chisti, Y., Camacho, F. G., Grima, E. M. Biotechnol. Adv., 21, 585–598 (2003). Producing drugs from marine sponges. [Reprint PDF]

Camacho Rubio, F., García Camacho, F., Fernández Sevilla, J. M., Chisti, Y., Molina Grima, E., Biotechnol. Bioeng., 81, 459–473 (2003). A mechanistic model of photosynthesis in microalgae. [Reprint PDF]

Molina Grima, E., Belarbi, E. -H., Acién Fernández, F. G., Robles Medina A., Chisti, Y., Biotechnol. Adv., 20, 491–515 (2003). Recovery of microalgal biomass and metabolites: process options and economics.  [Reprint PDF]

Chisti, Y., Trends Biotechnol., 21, 89–93 (2003). Sonobioreactors: using ultrasound for enhanced microbial productivity. [Reprint PDF]


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