Contact details +6469517650

Dr Stefan Harjes

Research Officer (Biochemistry)

School of Food Technology and Natural Sciences

Research Projects

Summary of Research Projects

Position Current Completed
Postdoctoral Fellow 1 0
Project Leader 1 0

Research Outputs

Journal

Harjes, S., Kurup, HM., Rieffer, AE., Bayarjargal, M., Filitcheva, J., Su, Y., . . . Jameson, GB. (2023). Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A. Nature Communications. 14(1)
[Journal article]Authored by: Filichev, V., Harjes, S., Jameson, G., Kurup, H.
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Kurup, HM., Kvach, MV., Harjes, S., Jameson, GB., Harjes, E., & Filichev, VV. (2023). Seven-membered ring nucleobases as inhibitors of human cytidine deaminase and APOBEC3A. Organic and Biomolecular Chemistry. 21(24), 5117-5128
[Journal article]Authored by: Filichev, V., Harjes, S., Jameson, G., Kurup, H.
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Harjes, S., Kurup, HM., Rieffer, AE., Bayaijargal, M., Filitcheva, J., Su, Y., . . . Jameson, GB. (2023). Structure-guided inhibition of the cancer DNA-mutating enzyme APOBEC3A.. bioRxiv.
[Journal article]Authored by: Filichev, V., Harjes, S., Jameson, G., Kurup, H.
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Kurup, HM., Kvach, MV., Harjes, S., Barzak, FM., Jameson, GB., Harjes, E., . . . Filichev, VV. (2022). Design, Synthesis, and Evaluation of a Cross-Linked Oligonucleotide as the First Nanomolar Inhibitor of APOBEC3A. Biochemistry. 61(22), 2568-2578
[Journal article]Authored by: Filichev, V., Harjes, S., Jameson, G., Kurup, H.
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3
Barzak, FM., Ryan, TM., Mohammadzadeh, N., Harjes, S., Kvach, MV., Kurup, HM., . . . Jameson, GB. (2022). Small-Angle X-ray Scattering (SAXS) Measurements of APOBEC3G Provide Structural Basis for Binding of Single-Stranded DNA and Processivity. Viruses. 14(9)
[Journal article]Authored by: Filichev, V., Harjes, S., Jameson, G., Kurup, H.
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Harjes, E., Jameson, GB., Tu, YH., Burr, N., Loo, TS., Goroncy, AK., . . . Norris, GE. (2021). Experimentally based structural model of Yih1 provides insight into its function in controlling the key translational regulator Gcn2. FEBS Letters. 595(3), 324-340
[Journal article]Authored by: Edwards, P., Harjes, S., Jameson, G., Loo, T., Sattlegger, E.
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1
Kvach, MV., Barzak, FM., Harjes, S., Schares, HAM., Kurup, HM., Jones, KF., . . . Filichev, VV. (2020). Differential Inhibition of APOBEC3 DNA-Mutator Isozymes by Fluoro- and Non-Fluoro-Substituted 2′-Deoxyzebularine Embedded in Single-Stranded DNA. ChemBioChem. 21(7), 1028-1035
[Journal article]Authored by: Filichev, V., Harjes, S., Jameson, G., Kurup, H.
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Barzak, FM., Harjes, S., Kvach, MV., Kurup, HM., Jameson, GB., Filichev, VV., . . . Harjes, E. (2019). Selective inhibition of APOBEC3 enzymes by single-stranded DNAs containing 2′-deoxyzebularine. Organic and Biomolecular Chemistry. 17(43), 9435-9441
[Journal article]Authored by: Filichev, V., Harjes, S., Jameson, G., Kurup, H.
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Kvach, MV., Barzak, FM., Harjes, S., Schares, HAM., Jameson, GB., Ayoub, AM., . . . Harjes, E. (2019). Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2′-Deoxyzebularine Analogues. Biochemistry. 58(5), 391-400
[Journal article]Authored by: Filichev, V., Harjes, S., Jameson, G.
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Harjes, S., Jameson, GB., Filichev, VV., Edwards, PJB., & Harjes, E. (2017). NMR-based method of small changes reveals how DNA mutator APOBEC3A interacts with its single-stranded DNA substrate. Nucleic Acids Research. 45(9), 5602-5613
[Journal article]Authored by: Edwards, P., Filichev, V., Harjes, S., Jameson, G.
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Harjes, S., Solomon, WC., Li, M., Chen, KM., Harjes, E., Harris, RS., . . . Matsuo, H. (2013). Impact of H216 on the DNA binding and catalytic activities of the HIV restriction factor APOBEC3G. Journal of Virology. 87(12), 7008-7014
[Journal article]Authored by: Harjes, S.
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Harjes, E., Harjes, S., Wohlgemuth, S., Müller, KH., Krieger, E., Herrmann, C., . . . Bayer, P. (2006). GTP-Ras Disrupts the Intramolecular Complex of C1 and RA Domains of Nore1. Structure. 14(5), 881-888
[Journal article]Authored by: Harjes, S.
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Harjes, S., Bayer, P., & Scheidig, AJ. (2005). The crystal structure of human PAPS synthetase 1 reveals asymmetry in substrate binding. Journal of Molecular Biology. 347(3), 623-635
[Journal article]Authored by: Harjes, S.
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Zerbst-Boroffka, I., Kamaltynow, RM., Harjes, S., Kinne-Saffran, E., & Gross, J. (2005). TMAO and other organic osmolytes in the muscles of amphipods (Crustacea) from shallow and deep water of Lake Baikal. Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 142(1), 58-64
[Journal article]Authored by: Harjes, S.
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Harjes, S., Scheidig, A., & Bayer, P. (2004). Expression, purification and crystallization of human 3′- phosphoadenosine-5′-phosphosulfate synthetase 1. Acta Crystallographica Section D: Biological Crystallography. 60(2), 350-352
[Journal article]Authored by: Harjes, S.
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Bayer, P., & Harjes, S. (2001). TonB - A mediator of iron uptake in bacteria. Trends in Biochemical Sciences. 26(8), 472
[Journal article]Authored by: Harjes, S.
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IP

Kurup, H., Filichev, VV., Harjes, E., Harjes, S., Jameson, G., Kvach, M., . . . Su, Y.(2022). . WO2022162536: SINGLE STRANDED DNA ENZYME INHIBITORS
[Patent]Authored by: Filichev, V., Harjes, S., Jameson, G., Kurup, H.Contributed to by: Kurup, H.
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Conference

Sattlegger, E., Harjes, E., Jameson, G., Tu, J., Burr, N., Loo, T., . . . Norris, G. (2018). Deciphering intramolecular interactions in Yih1, a negative regulator of the protein kinase Gcn2.. Poster session presented at the meeting of Translational Control Meeting,Cold Spring Harbor, NY, USA
[Conference Poster]Authored by: Edwards, P., Harjes, S., Jameson, G., Loo, T., Sattlegger, E.
Filichev, VV., Harjes, S., Barzak, F., Kvach, MV., Jameson, GB., & Harris, RS. (2017). Modulating APOBEC deaminase activity with ssDNA containing zebularine. , 7th Cambridge Symposium on Nucleic Acids Chemistry and Biology
[Conference Abstract]Authored by: Filichev, V., Harjes, S., Jameson, G.
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Harjes, E., Harjes, S., Filichev, V., Jameson, GB., & Edwards, P.(2016, October). How DNA mutating enzymes interact with their DNA substrates. .
[Conference]Authored by: Edwards, P., Filichev, V., Harjes, S., Jameson, G.
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