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Dr David Popovich staff profile picture

Contact details +64 (06) 356 9099  ext. 84570

Dr David Popovich PhD, MSc, BSc

Senior Lecturer in Human Nutrition

School of Food and Advanced Technology

My work is very much focused on plant secondary metabolites and potential to alter or prevent disease. I am particular interested in New Zealand grown plant food phytochemical profiles. . 

Professional

Contact details

  • Ph: 6-951-7570
    Location: A2.03, Riddet Complex A
    Campus: Turitea

Qualifications

  • Doctor of Philosophy - University of British Columbia (2004)
  • Master of Science - University of Toronto (1996)
  • Bachelor of Science - University of Toronto (1991)

Research Expertise

Research Interests

My work centres on New Zealand grown edible plants and agricultural plant waste. These sources will be analyzed for bioactive molecultes that may play a role in health.  A variety of biological models are used from cultured human cells, bacterial, and fungi. If you have an interesting plant and it is grown in New Zealand please contact me for a discussion 

Google scholar page

https://scholar.google.com/citations?hl=en&user=Q8-9Zi8AAAAJ

Area of Expertise

Field of research codes
Analytical Chemistry (030100):
Biochemistry and Cell Biology (060100): Biological Sciences (060000):
Biologically Active Molecules (030401):
Cell Development, Proliferation and Death (060103):
Characterisation of Biological Macromolecules (030403): Chemical Science (030000): Medicinal and Biomolecular Chemistry (030400): Medicinal and Biomolecular Chemistry not elsewhere classified (030499): Molecular Medicine (030405)

Research Projects

Summary of Research Projects

Position Current Completed
Project Leader 1 2

Research Outputs

Journal

Chen, W., Balan, P., & Popovich, DG. (2020). Changes of Ginsenoside Composition in the Creation of Black Ginseng Leaf. Molecules. 25(12)
[Journal article]Authored by: Balan, P., Popovich, D.
Chen, W., Balan, P., & Popovich, DG. (2020). Comparison of ginsenoside components of various tissues of new zealand forest-grown asian ginseng (Panax ginseng) and american ginseng (panax quinquefolium l.). Biomolecules. 10(3)
[Journal article]Authored by: Balan, P., Popovich, D.
Chen, W., Balan, P., & Popovich, DG. (2019). Review of ginseng anti-diabetic studies. Molecules. 24(24)
[Journal article]Authored by: Balan, P., Popovich, D.
Chen, W., Balan, P., & Popovich, DG. (2019). Analysis of ginsenoside content (Panax ginseng) from different regions. Molecules. 24(19)
[Journal article]Authored by: Balan, P., Popovich, D.
Chen, W., Balan, P., & Popovich, DG. (2019). Ginsenosides analysis of New Zealand–grown forest Panax ginseng by LC-QTOF-MS/MS. Journal of Ginseng Research.
[Journal article]Authored by: Balan, P., Popovich, D.
Kopetschny, H., Rowlands, D., Popovich, D., & Thomson, J. (2018). Long-distance triathletes' intentions to manipulate energy and macronutrient intake over a training macrocycle. International Journal of Sport Nutrition and Exercise Metabolism. 28(5), 515-521
[Journal article]Authored by: Popovich, D., Rowlands, D.
Tan, JS., Yeo, CR., & Popovich, DG. (2017). Fermentation of protopanaxadiol type ginsenosides (PD) with probiotic Bifidobacterium lactis and Lactobacillus rhamnosus. Applied Microbiology and Biotechnology. 101(13), 5427-5437
[Journal article]Authored by: Popovich, D.
Yeo, CR., Yong, JJ., & Popovich, DG. (2017). Isolation and characterization of bioactive polyacetylenes Panax ginseng Meyer roots. Journal of Pharmaceutical and Biomedical Analysis. 139, 148-155
[Journal article]Authored by: Popovich, D.
Ruan, W., Wei, Y., & Popovich, DG. (2015). Distinct Responses of Cytotoxic Ganoderma lucidum Triterpenoids in Human Carcinoma Cells. Phytotherapy Research. 29(11), 1744-1752
[Journal article]Authored by: Popovich, D.
Ruan, W., Lim, AHH., Huang, LG., & Popovich, DG. (2014). Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth. Natural Product Research. 28(24), 2264-2272
[Journal article]Authored by: Popovich, D.
Ruan, W., Lim, AHH., Huang, LG., & Popovich, DG. (2014). Extraction optimisation and isolation of triterpenoids from Ganoderma lucidum and their effect on human carcinoma cell growth. Natural Product Research.
[Journal article]Authored by: Popovich, D.
Popovich, DG., Sia, SY., Zhang, W., & Lim, ML. (2014). The color and size of chili peppers (Capsicum annuum) influence Hep-G2 cell growth. International Journal of Food Sciences and Nutrition. 65(7), 881-885
[Journal article]Authored by: Popovich, D.
Wei, Y., & Popovich, DG. (2013). Red azaphilone pigments extracted from red yeast rice induces cellular senescence and reduces viability in HepG2 cells. Biomedicine and Preventive Nutrition. 3(4), 331-337
[Journal article]Authored by: Popovich, D.
Wei, Y., & Popovich, DG. (2012). Pleiotropic effects of red yeast rice (Monascus Purpureus). , 307-318
[Journal article]Authored by: Popovich, D.
Ruan, W., & Popovich, DG. (2012). Evidence of bioactivity from Ganoderma Lucidum triterpenoids in cultured cell models. , 145-156
[Journal article]Authored by: Popovich, D.
Yeo, CR., & Popovich, DG. (2012). Potential of triterpenoids from ginseng (Panax Quinquefolius and Panax Ginseng C.A. meyer) to regulate cultured adipocytes. , 123-134
[Journal article]Authored by: Popovich, D.
Zhang, W., & Popovich, DG. (2012). Recent developments of soyasaponins from soy (Glycine Max (L.)) bioactivity in cell models. , 157-162
[Journal article]Authored by: Popovich, D.
Kitts, DD., & Popovich, DG. (2003). Ginseng. , 78-92
[Journal article]Authored by: Popovich, D.
Zhang, W., Tang, FY., Yeo, MC., & Popovich, DG. (2012). Fermentation of group b soyasaponins with probiotic lactobacillus rhamnosus. Journal of Food Biochemistry. 36(2), 179-188
[Journal article]Authored by: Popovich, D.
Ruan, W., & Popovich, DG. (2012). Ganoderma lucidum triterpenoid extract induces apoptosis in human colon carcinoma cells (Caco-2). Biomedicine and Preventive Nutrition. 2(3), 203-209
[Journal article]Authored by: Popovich, D.
Kitts, DD., Kopec, A., Zawistowski, J., & Popovich, DG. (2012). Effects of high molecular weight alcohols from sugar cane fed alone or in combination with plant sterols on lipid profile and antioxidant status of Wistar rats. Applied Physiology, Nutrition and Metabolism. 37(5), 938-946
[Journal article]Authored by: Popovich, D.
Yeo, CR., Yang, C., Wong, TY., & Popovich, DG. (2011). A quantified ginseng (Panax ginseng C.A. Meyer) extract influences lipid acquisition and increases adiponectin expression in 3T3-L1 cells. Molecules. 16(1), 477-492
[Journal article]Authored by: Popovich, D.
Popovich, DG., Lee, Y., Li, L., & Zhang, W. (2011). Momordica charantia seed extract reduces pre-adipocyte viability, affects lactate dehydrogenase release, and lipid accumulation in 3T3-L1 cells. Journal of Medicinal Food. 14(3), 201-208
[Journal article]Authored by: Popovich, D.
Popovich, DG., Yeo, CR., & Lee, SM. (2011). Ginseng (Panax quinquefolius) reduces cell growth, lipid acquisition and increases adiponectin expression in 3T3-L1 cells. Evidence-based Complementary and Alternative Medicine. 2011
[Journal article]Authored by: Popovich, D.
Popovich, DG., Yeo, SY., & Zhang, W. (2011). Ginseng (Panax quinquefolius) and licorice (Glycyrrhiza uralensis) root extract combinations increase hepatocarcinoma cell (Hep-G2) viability. Evidence-based Complementary and Alternative Medicine. 2011
[Journal article]Authored by: Popovich, D.
Liu, J., Zhang, W., Jing, H., & Popovich, DG. (2010). Bog bilberry (vaccinium uliginosum l.) extract reduces cultured hep-g2, caco-2, and 3t3-l1 cell viability, affects cell cycle progression, and has variable effects on membrane permeability. Journal of Food Science. 75(3)
[Journal article]Authored by: Popovich, D.
Zhang, W., & Popovich, DG. (2010). Group B oleanane triterpenoid extract containing soyasaponins i and III from soy flour induces apoptosis in HEP-G2 cells. Journal of Agricultural and Food Chemistry. 58(9), 5315-5319
[Journal article]Authored by: Popovich, D.
Popovich, DG., Li, L., & Zhang, W. (2010). Bitter melon (Momordica charantia) triterpenoid extract reduces preadipocyte viability, lipid accumulation and adiponectin expression in 3T3-L1 cells. Food and Chemical Toxicology. 48(6), 1619-1626
[Journal article]Authored by: Popovich, D.
Popovich, DG., Tiaras, F., Yeo, CR., & Zhang, W. (2010). Lovastatin interacts with natural products to influence cultured hepatocarcinoma cell (Hep-G2) growth. Journal of the American College of Nutrition. 29(3), 204-210
[Journal article]Authored by: Popovich, D.
Zhang, W., & Popovich, DG. (2010). Behaviour of soyasapogenol B under optimised hydrolysis and ESI mass spec conditions. Food Chemistry. 123(4), 993-999
[Journal article]Authored by: Popovich, D.
Zhang, W., Teng, SP., & Popovich, DG. (2009). Generation of group B soyasaponins I and III by hydrolysis. Journal of Agricultural and Food Chemistry. 57(9), 3620-3625
[Journal article]Authored by: Popovich, D.
Zhang, W., & Popovich, DG. (2009). Chemical and biological characterization of oleanane triterpenoids from soy. Molecules. 14(8), 2959-2975
[Journal article]Authored by: Popovich, D.
Zhang, W., Yeo, MC., Tang, FY., & Popovich, DG. (2009). Bioactive responses of Hep-G2 cells to soyasaponin extracts differs with respect to extraction conditions. Food and Chemical Toxicology. 47(9), 2202-2208
[Journal article]Authored by: Popovich, D.
Zhang, W., & Popovich, DG. (2008). Effect of soyasapogenol A and soyasapogenol B concentrated extracts on Hep-G2 cell proliferation and apoptosis. Journal of Agricultural and Food Chemistry. 56(8), 2603-2608
[Journal article]Authored by: Popovich, D.
Elisia, I., Popovich, DG., Hu, C., & Kitts, DD. (2008). Evaluation of viability assays for anthocyanins in cultured cells. Phytochemical Analysis. 19(6), 479-486
[Journal article]Authored by: Popovich, D.
Kitts, DD., Popovich, DG., & Hu, C. (2007). Characterizing the mechanism for ginsenoside-induced cytotoxicity in cultured leukemia (THP-1) cells. Canadian Journal of Physiology and Pharmacology. 85(11), 1173-1183
[Journal article]Authored by: Popovich, D.
Elisia, I., Hu, C., Popovich, DG., & Kitts, DD. (2007). Antioxidant assessment of an anthocyanin-enriched blackberry extract. Food Chemistry. 101(3), 1052-1058
[Journal article]Authored by: Popovich, D.
Popovich, DG., Hu, C., Durance, TD., & Kitts, DD. (2005). Retention of ginsenosides in dried ginseng root: Comparison of drying methods. Journal of Food Science. 70(6), s355-s358
[Journal article]Authored by: Popovich, D.
Popovich, DG., & Kitts, DD. (2004). Generation of ginsenosides Rg3 and Rh2 from North American ginseng. Phytochemistry. 65(3), 337-344
[Journal article]Authored by: Popovich, D.
Popovich, DG., & Kitts, DD. (2004). Ginsenosides 20(S)-protopanaxadiol and Rh2 reduce cell proliferation and increase sub-G<inf>1</inf> cells in two cultured intestinal cell lines, Int-407 and Caco-2. Canadian Journal of Physiology and Pharmacology. 82(3), 183-190
[Journal article]Authored by: Popovich, D.
Popovich, DG., & Kitts, DD. (2004). Mechanistic studies on protopanaxadiol, Rh2, and ginseng (Panax quinquefolius) extract induced cytotoxicity in intestinal Caco-2 cells. Journal of Biochemical and Molecular Toxicology. 18(3), 143-149
[Journal article]Authored by: Popovich, D.
Popovich, DG., & Kitts, DD. (2002). Structure-function relationship exists for ginsenosides in reducing cell proliferation and inducing apoptosis in the human leukemia (THP-1) cell line. Archives of Biochemistry and Biophysics. 406(1), 1-8
[Journal article]Authored by: Popovich, D.
Jenkins, DJA., Kendall, CWC., Popovich, DG., Vidgen, E., Mehling, CC., Vuksan, V., . . . Connelly, PW. (2001). Effect of a very-high-fiber vegetable, fruit, and nut diet on serum lipids and colonic function. Metabolism: Clinical and Experimental. 50(4), 494-503
[Journal article]Authored by: Popovich, D.
Jenkins, DJA., Popovich, DG., Kendall, CWC., Venketeshwer Rao, A., Wolever, TMS., Tariq, N., . . . Cunnane, SC. (1997). Metabolic effects of non-absorbable carbohydrates. Scandinavian Journal of Gastroenterology, Supplement. 32(222), 10-13
[Journal article]Authored by: Popovich, D.
Jenkins, DJA., Popovich, DG., Kendall, CWC., Vidgen, E., Tariq, N., Ransom, TPP., . . . Patten, R. (1997). Effect of a diet high in vegetables, fruit, and nuts on serum lipids. Metabolism: Clinical and Experimental. 46(5), 530-537
[Journal article]Authored by: Popovich, D.
Popovich, DG., Jenkins, DJA., Kendall, CWC., Dierenfeld, ES., Carroll, RW., Tariq, N., . . . Vidgen, E. (1997). The western lowland gorilla diet has implications for the health of humans and other hominoids. Journal of Nutrition. 127(10), 2000-2005
[Journal article]Authored by: Popovich, D.
Popovich, DG., Kendall, CWC., Ransom, TPP., Wolever, TMS., Tariq, N., Rosenberg, RS., . . . Jenkins, DJA. (1996). Glycemic index of commonly consumed foods. FASEB Journal. 10(3)
[Journal article]Authored by: Popovich, D.

Book

Chen, W., Balan, P., & Popovich, DG. (2019). Comparison of the ginsenoside composition of Asian ginseng (Panax ginseng) and American ginseng (Panax quinquefolius L.) and their transformation pathways. In Studies in Natural Products Chemistry. (pp. 161 - 195).
[Chapter]Authored by: Balan, P., Popovich, D.
Popovich, DG., & Kitts, DD. (2006). Nutrition and Cancer Prevention. In AB. Awad, & PG. Bradford (Eds.) Nutrition and Cancer Prevention. (pp. 457 - 483). : CRC Press
[Chapter]Authored by: Popovich, D.
Popovich, DG., & Kitts, DD. (2005). Anticancer activity of ginseng and soy saponins. In Nutrition and Cancer Prevention. (pp. 457 - 486).
[Chapter]Authored by: Popovich, D.
Popovich, DG., & Kitts, DD. (2003). Ginseng. In DH. Watson (Ed.) Performance functional foods. (pp. 78 - 88). Cambridge: Woodhead Publishing LTD
[Chapter]Authored by: Popovich, D.

Conference

Aaij, R., Adeva, B., Adinolfi, M., Ajaltouni, Z., Akar, S., Albrecht, J., . . . Cadeddu, S.LHCb Collaboration. Nuclear Physics A. (pp. 987 - 993). 0375-9474.
[Conference]Authored by: Popovich, D.
Aubert, B., Bona, M., Boutigny, D., Karyotakis, Y., Lees, JP., Poireau, V., . . . Winstrom, LO.Measurement of the time-dependent CP asymmetry in B<sup>0</sup>→ K<sup>*0</sup> γ decays. 23rd International Symposium on Lepton-Photon Interactions at High Energy, LP 2007.
[Conference]Authored by: Popovich, D.
Aubert, B., Bona, M., Boutigny, D., Karyotakis, Y., Lees, JP., Poireau, V., . . . Winstrom, LO.Time-dependent dalitz plot analysis of B<sup>0</sup> → K <sup>0</sup><inf>S</inf> π+π-. 23rd International Symposium on Lepton-Photon Interactions at High Energy, LP 2007.
[Conference]Authored by: Popovich, D.
Aubert, B., Bona, M., Boutigny, D., Karyotakis, Y., Lees, JP., Poireau, V., . . . Winstrom, LO.Measurement of the branching fraction ratios and CP asymmetries in B-→ D<sup>0</sup><inf>CP</inf> K-decays. 23rd International Symposium on Lepton-Photon Interactions at High Energy, LP 2007.
[Conference]Authored by: Popovich, D.
Aubert, B., Bona, M., Boutigny, D., Karyotakis, Y., Lees, JP., Poireau, V., . . . Winstrom, LO.Time-dependent analysis of the decay B<sup>0</sup> → ρ<sup>0</sup>ρ<sup>0</sup>. 23rd International Symposium on Lepton-Photon Interactions at High Energy, LP 2007.
[Conference]Authored by: Popovich, D.
Aubert, B., Bona, M., Boutigny, D., Karyotakis, Y., P Lees, J., Poireau, V., . . . Winstrom, LO.Measurements of the branching fractions of B<sup>0</sup>→ K <sup>*0</sup>K<sup>+</sup>K<sup>-</sup>, B<sup>0</sup>→ K<sup>*0</sup> π+K<sup>-</sup>, B<sup>0</sup>→ K <sup>*0</sup>K+π-, and B<sup>0</sup>→ K <sup>*0</sup>π+ π-. 23rd International Symposium on Lepton-Photon Interactions at High Energy, LP 2007.
[Conference]Authored by: Popovich, D.
Aubert, B., Bona, M., Boutigny, D., Karyotakis, Y., Lees, JP., Poireau, V., . . . Seiden, A.Search for the rare charmless hadronic decay B<sup>+</sup>→ a <sup>+</sup><inf>0</inf> π<inf>0</inf>. 23rd International Symposium on Lepton-Photon Interactions at High Energy, LP 2007.
[Conference]Authored by: Popovich, D.
Aubert, B., Bona, M., Boutigny, D., Karyotakis, Y., Lees, JP., Poireau, V., . . . Winstrom, LO.Measurement of the branching fractions of exclusive B̄ → D/D <sup>*</sup>/D(<sup>*</sup>)πℓ-̄νℓ decays in events tagged by a fully reconstructed B meson. 23rd International Symposium on Lepton-Photon Interactions at High Energy, LP 2007.
[Conference]Authored by: Popovich, D.
Aubert, B., Bona, M., Boutigny, D., Karyotakis, Y., Lees, JP., Poireau, V., . . . Winstrom, LO.Measurement of the B<sup>0</sup>→ X-u ℓ+νℓ decays near the kinematic endpoint of the lepton spectrum and search for violation of isospin symmetry. 23rd International Symposium on Lepton-Photon Interactions at High Energy, LP 2007.
[Conference]Authored by: Popovich, D.
Aubert, B., Bona, M., Boutigny, D., Karyotakis, Y., Lees, JP., Poireau, V., . . . Winstrom, LO.Evidence for b → d γ transitions from a sum of exclusive final states in the hadronic final state mass range 1.0GeV/c<sup>2</sup> &lt; M(X <inf>d</inf>) &lt; 1.8GeV/c<sup>2</sup>. 23rd International Symposium on Lepton-Photon Interactions at High Energy, LP 2007.
[Conference]Authored by: Popovich, D.
Popovich, DG., & Kitts, DD.Specific Ginsenosides and a North American ginseng Rh2 enriched fraction inhibits proliferation, alters membrane properties in cultured intestinal cell line (Caco-2). FASEB JOURNAL. 19 (5)(pp. A1455 - A1455). 0892-6638.
[Conference]Authored by: Popovich, D.
Popovich, DG., & Kitts, DD.Ginsenosides can inhibit proliferation and induce apoptosis in cultured leukemia and intestinal cells but effects vary according to the structure of the compounds. FASEB JOURNAL. 17 (5)(pp. A762 - A762). 0892-6638.
[Conference]Authored by: Popovich, D.

Teaching and Supervision

Teaching Statement

I am accepting PhD students from all over the world provided they can meet the entry requirments. Scholarships are available but are competitive and students need a research based MSc and at least an A- grade in the last two years of study. Publications help.

Courses Coordinated

Graduate Supervision Statement

Currently I have four PhD students in the lab in my pervious university I supervised 6 PhD students and with over 55 post graduate projects.I am accepting PhD students from all over the world provided they can meet the entry requirments. Scholarships are available but are competitive and students need a research based MSc and at least an A- grade in the last two years of study. Publications help for entry and they will be expected for your PhD.


Summary of Doctoral Supervision

Position Current Completed
Main Supervisor 4 0

Current Doctoral Supervision

Main Supervisor of:

  • Iqra Zulfiqar - Doctor of Philosophy
    Characterizing physical and bioactive potential of ancient flours and edible grasses
  • Wenliang Xu - Doctor of Philosophy
    Screening a select group of New Zealand grown plants: the hunt for bioactive molecules.
  • Wei Chen - Doctor of Philosophy
    Characterizing New Zealand forest grown ginseng (Panax ginseng and Panax quinquefolius L.)

Media and Links

Media

  • 03 Dec 2015 - Online
    This One Condiment Instantly Improves Your Diet
    The article by Mandy Oaklander from Time.com describes the potential health benefits from chili peppers and the evidence was based on my published work The color and size of chili peppers (Capsicum

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