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Prof Kathryn Stowell staff profile picture

Contact details +6469517721

Prof Kathryn Stowell BSc(Hons), PhD

Professor in Biochemistry

Doctoral Supervisor
School of Fundamental Sciences
  • Started working life as a Biochemistry technician at Massey University in 1976
  • Graduated BSc(Hons) in 1985 and PhD in 1991 (both in Biochemistry) from Massey University
  • Post-doctoral Fellow Sir William Dunn School of Pathology, University of Oxford 1991-1993
  • Appointed lecturer in Biochemistry, Massey University from 1993
  • Applied Biosystems NZSBMB Award in 2009
  • Appointed Associate Professor in Biochemistry in 2009
  • Research laboratory accredited by IANZ for medical testing 2010
  • Appointed as an Officer of the New Zealand Order of Merit (ONZM) in 2015 for contribution to Biomedical Science
  • Appointed Professor in Biochemistry in 2016
  • Registered as a Medical Laboratory Scientist in 2018


Roles and Responsibilities

  • Trustee and Board member of PNMRF since 1996
  • Secretary of NZSBMB from 1998-2002
  • Director of Postgraduate studies in IMBS from 2000
  • Biochemistry Major leader from 2001
  • Director of Postgraduate studies in IFS/SFS from 2013
  • Appointed Functional Genetics Officer of the European Malignant Hyperthermia Group from 2016
  • Appointed Vice President of the PNMRF in 2017
  • Regional Representative for NZSBMB from 2018
  • Appointed to RYR1 ClinGen Expert Panel in 2019

I am a biochemist with a background in human physiological biochemistry, protein biochemistry and regulation of gene expression. My research interests turned towards molecular genetics with a focus on the underlying causes of Malignant Hyperthermia in humans, but I remain a biochemist at heart. I work closely with anaesthetists at Palmerston North hospital on DNA analysis for Malignant Hyperthermia and calcium homeostasis in skeletal muscle. I run a research laboratory as well as an IANZ accredited diagnostic laboratory for Malignant Hyperthermia and teach a range of subjects including DNA structure, function and analysis, metabolic biochemistry and regulation of gene expression.

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Professional

Contact details

  • Ph: +64 6 9517721 ext 84721
    Location: ScD3.08a, Science Tower D
    Campus: Manawatu

Qualifications

  • Bachelor of Science (Honours) - Massey University (1986)
  • Doctor of Philosophy - Massey University (1991)

Certifications and Registrations

  • Licence, Supervisor, Massey University

Prizes and Awards

  • Officer of the New Zealand Order of Merit for services to Biomedical Science - Her Majesty Queen Elizabeth II (2015)
  • New Zealand Society for Molecular Biology and Biochemistry/ Applied Biosystems award - (2009)

Research Expertise

Research Interests

  • Biochemistry and molecular genetics of malignant hyperthermia
  • Functional analysis of RYR1 variants

Thematics

Health and Well-being

Area of Expertise

Field of research codes
Biochemistry and Cell Biology (060100): Biological Sciences (060000): Gene Expression (incl. Microarray and other genome-wide approaches) (060405): Genetics (060400):
Medical And Health Sciences (110000): Medical Biochemistry and Metabolomics (110100): Medical Biochemistry: Nucleic Acids (110105): Medical Biochemistry: Proteins and Peptides (incl. Medical Proteomics) (110106): Preventive Medicine (111716): Public Health and Health Services (111700):
Receptors and Membrane Biology (060110)

Keywords

  • SNP detection and HRM analysis
  • RT-qPCR
  • General protein biochemistry
  • General molecular biology
  • Targeted exon and whole exome sequencing
  • Calcium homeostasis in skeletal muscle

Research Projects

Summary of Research Projects

Position Current Completed
Not Specified 0 1
Project Leader 6 32

Current Projects

Project Title: Genetic Diagnosis of Malignant Hyperthermia

Our research will improve diagnosis of malignant hyperthermia (MH), which is a potentially fatal genetic disorder triggered by inhalational anaesthetics. If MH is diagnosed before surgery safe anaesthesia can be given to the patient. The current diagnosis is morbidly invasive (requiring a large muscle biopsy) and costly. Recently, we have found new mutations in MH-susceptible families that could form the basis of DNA tests for MH. Before carrying out these tests, we must show that the new mutations cause MH. This will allow us to provide simple, rapid, non-invasive and inexpensive DNA testing.
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Date Range: 2020 - 2022

Funding Body: Palmerston North Medical Research Foundation

Project Team:

Project Title: NSC - Biological mimicry for medical diagnostics

Date Range: 2019 - 2021

Funding Body: Callaghan Innovation

Project Team:

Completed Projects

Project Title: Functional effects of RYR1 mutations

Malignant hyperthermia (MH) is a genetic disorder that is triggered by inhalational anaesthetics administered for general anaesthesia. MH manifests as a range of clinical symptoms including muscle rigidity, irregular heart rate and high temperature. Metabolically, MH results from dysregulated skeletal muscle homeostasis. If not rapidly recognized and treated, an MH episode can lead to death. If MH-susceptibility can be determined prior to general anaesthesia, an alternative non-triggering and safe anaesthetic procedure is used, thus MH can potentially be prevented. We use a range of state-of-the-art molecular tools to identify causative mutations in families known to be MH-susceptible. Once mutations have been shown to segregate within a family, we move to functional characterization to confirm dysregulation of calcium homeostasis. Finally, we develop and implement DNA-based predictive diagnostic tests. Thus far we have identified mutations that cause MH, and implemented DNA-based diagnostic tests for approximately half the New Zealand families affected by this disorder. This is an example of translational medical research and is carried out in collaboration with specialist anaesthetists at Palmerston North Hospital.
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Date Range: 2012 - 2012

Funding Body: Massey University

Project Team:

Project Title: Novel determinants of malignant hyperthermia

Malignant hyperthermia (MH) is a genetic disorder that is triggered by inhalational anaesthetics administered for general anaesthesia. MH manifests as a range of clinical symptoms including muscle rigidity, irregular heart rate and high temperature. Metabolically, MH results from dysregulated skeletal muscle homeostasis. If not rapidly recognized and treated, an MH episode can lead to death. If MH-susceptibility can be determined prior to general anaesthesia, an alternative non-triggering and safe anaesthetic procedure is used, thus MH can potentially be prevented. We use a range of state-of-the-art molecular tools to identify causative mutations in families known to be MH-susceptible. Once mutations have been shown to segregate within a family, we move to functional characterization to confirm dysregulation of calcium homeostasis. Finally, we develop and implement DNA-based predictive diagnostic tests. Thus far we have identified mutations that cause MH, and implemented DNA-based diagnostic tests for approximately half the New Zealand families affected by this disorder. This is an example of translational medical research and is carried out in collaboration with specialist anaesthetists at Palmerston North Hospital.
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Date Range: 2009 - 2010

Funding Body: Massey University

Project Team:

Project Title: Malignant Hyperthermia Mutations

Malignant hyperthermia (MH) is a genetic disorder that is triggered by inhalational anaesthetics administered for general anaesthesia. MH manifests as a range of clinical symptoms including muscle rigidity, irregular heart rate and high temperature. Metabolically, MH results from dysregulated skeletal muscle homeostasis. If not rapidly recognized and treated, an MH episode can lead to death. If MH-susceptibility can be determined prior to general anaesthesia, an alternative non-triggering and safe anaesthetic procedure is used, thus MH can potentially be prevented. We use a range of state-of-the-art molecular tools to identify causative mutations in families known to be MH-susceptible. Once mutations have been shown to segregate within a family, we move to functional characterization to confirm dysregulation of calcium homeostasis. Finally, we develop and implement DNA-based predictive diagnostic tests. Thus far we have identified mutations that cause MH, and implemented DNA-based diagnostic tests for approximately half the New Zealand families affected by this disorder. This is an example of translational medical research and is carried out in collaboration with specialist anaesthetists at Palmerston North Hospital.
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Date Range: 2008 - 2009

Funding Body: Massey University

Project Team:

Research Outputs

Journal

van den Bersselaar, LR., Greven, T., Bulger, T., Voermans, NC., van Petegem, F., Schiemann, AH., . . . Snoeck, MMJ. (2021). RYR1 variant c.38T>G, p.Leu13Arg causes hypersensitivity of the ryanodine receptor-1 and is pathogenic for malignant hyperthermia. British Journal of Anaesthesia. 127(2), e63-e65
[Journal article]Authored by: Schiemann, A., Stowell, K.
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Johnston, JJ., Dirksen, RT., Girard, T., Gonsalves, SG., Hopkins, PM., Riazi, S., . . . Biesecker, LG. (2021). Variant curation expert panel recommendations for RYR1 pathogenicity classifications in malignant hyperthermia susceptibility. Genetics in Medicine. 23(7), 1288-1295
[Journal article]Authored by: Stowell, K.
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Biesecker, LG., Dirksen, RT., Girard, T., Hopkins, PM., Riazi, S., Rosenberg, H., . . . Weber, J. (2020). Genomic Screening for Malignant Hyperthermia Susceptibility. Anesthesiology. , 1277-1282
[Journal article]Authored by: Stowell, K.
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Schiemann, AH., Roesl, C., Pollock, N., Langton, E., Bulger, T., & Stowell, KM. (2020). Identification and Functional Analysis of RYR1 Variants in a Family with a Suspected Myopathy and Associated Malignant Hyperthermia. Journal of Neuromuscular Diseases. 7(1), 51-60
[Journal article]Authored by: Schiemann, A., Stowell, K.
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Hudig, K., Pollock, N., Bulger, T., Machon, RG., Woodhead, A., Schiemann, AH., . . . Stowell, KM. (2019). Masseter muscle rigidity and the role of dna analysis to confirm malignant hyperthermia susceptibility. Anaesthesia and Intensive Care. 47(1), 60-68
[Journal article]Authored by: Schiemann, A., Stowell, K.
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Schiemann, AH., Bjorksten, AR., Gillies, RL., Hockey, BM., Ball, C., Pollock, N., . . . Stowell, KM. (2018). A genetic mystery in malignant hyperthermia 'solved'?. BRITISH JOURNAL OF ANAESTHESIA. 121(3), 681-682
[Journal article]Authored by: Stowell, K.
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Schiemann, AH., Bjorksten, AR., Gillies, RL., Hockey, BM., Ball, C., Pollock, N., . . . Stowell, KM. (2018). A genetic mystery in malignant hyperthermia ‘solved’?. British Journal of Anaesthesia. 121(3), 681-682
[Journal article]Authored by: Schiemann, A., Stowell, K.
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Grievink, A., & Stowell, K. (2010). Allele-specific differences in ryanodine receptor 1 mRNA expression levels may contribute to phenotypic variability in malignant hyperthermia. Default Journal, Please Provide Journal Name. 5, 10-20
[Journal article]Authored by: Stowell, K.
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Chan, TY., Bulger, TF., Stowell, KM., Gillies, RL., Langton, EE., Street, NE., . . . Pollock, NA. (2017). Evidence of Malignant Hyperthermia in Patients Administered Triggering Agents before Malignant Hyperthermia Susceptibility Identified: Missed Opportunities Prior to Diagnosis. Anaesthesia and Intensive Care. 45(6), 707-713
[Journal article]Authored by: Stowell, K.
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Frei, D., Stowell, KM., Langton, EE., McRedmond, L., Pollock, NA., & Bulger, TF. (2017). Administration of Anaesthetic Triggering Agents to Patients Tested Malignant Hyperthermia Normal and Their Relatives in New Zealand: An Update. Anaesthesia and Intensive Care. 45(5), 611-618
[Journal article]Authored by: Stowell, K.
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Parker, R., Schiemann, AH., Langton, E., Bulger, T., Pollock, N., Bjorksten, A., . . . Stowell, KM. (2017). Functional Characterization of C-terminal Ryanodine Receptor 1 Variants Associated with Central Core Disease or Malignant Hyperthermia. Journal of Neuromuscular Diseases. 4(2), 147-158
[Journal article]Authored by: Schiemann, A., Stowell, K.
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Merritt, A., Booms, P., Shaw, MA., Miller, DM., Daly, C., Bilmen, JG., . . . Hopkins, PM. (2017). Assessing the pathogenicity of RYR1 variants in malignant hyperthermia. British Journal of Anaesthesia. 118(4), 533-543
[Journal article]Authored by: Stowell, K.
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Stephens, J., Schiemann, AH., Roesl, C., Miller, D., Massey, S., Pollock, N., . . . Stowell, K. (2016). Functional analysis of RYR1 variants linked to malignant hyperthermia. Temperature. 3(2), 328-339
[Journal article]Authored by: Schiemann, A., Stowell, K.
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Schiemann, AH., & Stowell, KM. (2016). Comparison of pathogenicity prediction tools on missense variants in RYR1 and CACNA1S associated with malignant hyperthermia. British Journal of Anaesthesia. 117(1), 124-128
[Journal article]Authored by: Schiemann, A., Stowell, K.
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Rosenberg, H., Pollock, N., Schiemann, A., Bulger, T., & Stowell, K. (2015). Malignant hyperthermia: a review. Orphanet Journal of Rare Diseases. 10(1), 1-19
[Journal article]Authored by: Schiemann, A., Stowell, K.
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Barnes, C., Stowell, KM., Bulger, T., Langton, E., & Pollock, N. (2015). Safe duration of postoperative monitoring for malignant hyperthermia patients administered non-triggering anaesthesia: An update. Anaesthesia and Intensive Care. 43(1), 98-104
[Journal article]Authored by: Stowell, K.
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Roesl, C., Sato, K., Schiemann, A., Pollock, N., & Stowell, KM. (2014). Functional characterisation of the R2452W ryanodine receptor variant associated with malignant hyperthermia susceptibility. Cell calcium. 56(3), 195-201
[Journal article]Authored by: Stowell, K.
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Schiemann, AH., Paul, N., Parker, R., Pollock, N., Bulger, TF., & Stowell, KM. (2014). Functional characterization of 2 known ryanodine receptor mutations causing malignant hyperthermia. Anesthesia and Analgesia. 118(2), 375-380
[Journal article]Authored by: Stowell, K.
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Stowell, KM. (2014). DNA testing for malignant hyperthermia: The reality and the dream. Anesthesia and Analgesia. 118(2), 397-406
[Journal article]Authored by: Stowell, K.
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Schiemann, AH., Dürholt, EM., Pollock, N., & Stowell, KM. (2013). Sequence capture and massively parallel sequencing to detect mutations associated with malignant hyperthermia. British Journal of Anaesthesia. 110(1), 122-127
[Journal article]Authored by: Schiemann, A., Stowell, K.
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Sato, K., Roesl, C., Pollock, N., & Stowell, KM. (2013). Skeletal muscle ryanodine receptor mutations associated with malignant hyperthermia showed enhanced intensity and sensitivity to triggering drugs when expressed in human embryonic kidney cells. Anesthesiology. 119(1), 111-118
[Journal article]Authored by: Stowell, K.
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Pollock, N., Langton, EE., Stowell, KM., & Bulger, TF. (2011). Safety of exposure of malignant hyperthermia non-susceptible patients and their relatives to anaesthetic triggering agents. Anaesthesia and Intensive Care. 39(5), 887-894
[Journal article]Authored by: Stowell, K.
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Sato, K., Pollock, N., & Stowell, KM. (2010). Functional studies of RYR1 mutations in the skeletal muscle ryanodine receptor using human RYR1 complementary DNA. Anesthesiology. 112(6), 1350-1354
[Journal article]Authored by: Stowell, K.
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Grievink, H., & Stowell, KM. (2010). Allele-specific differences in ryanodine receptor 1 mRNA expression levels may contribute to phenotypic variability in malignant hyperthermia. ORPHANET JOURNAL OF RARE DISEASES. 5,
[Journal article]Authored by: Stowell, K.
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Merritt, A., Booms, P., Duke, A., Sato, K., Stowell, K., Steele, D., . . . Hopkins, P. (2010). Functional analysis of the p.Gly3990Val RYR1 variant using a human cDNA clone in HEK293 cells. British Journal of Anaesthesia. 105(5), 718P-718P
[Journal article]Authored by: Stowell, K.
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Stowell, KM. (2010). Malignant hyperthermia: A killer while you sleep?. New Zealand BioScience. 19(1), 13-15
[Journal article]Authored by: Stowell, K.
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Grievink, H., & Stowell, KM. (2008). Identification of ryanodine receptor 1 single-nucleotide polymorphisms by high-resolution melting using the LightCycler 480 System. Analytical Biochemistry. 374(2), 396-404
[Journal article]Authored by: Stowell, K.
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Anderson, AA., Brown, RL., Polster, B., Pollock, N., & Stowell, KM. (2008). Identification and biochemical characterization of a novel ryanodine receptor gene mutation associated with malignant hyperthermia. Anesthesiology. 108(2), 208-215
[Journal article]Authored by: Brown, R., Stowell, K.
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Stowell, KM. (2008). Malignant hyperthermia: A pharmacogenetic disorder. Pharmacogenomics. 9(11), 1657-1672
[Journal article]Authored by: Stowell, K.
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Stowell, KM., & Pollock, N. (2008). DNA analysis and malignant hyperthermia susceptibility. Anaesthesia and Intensive Care. 36(3)
[Journal article]Authored by: Stowell, K.
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Rosenberg, H., Davis, M., James, D., Pollock, N., & Stowell, KM. (2007). Malignant hyperthermia. Orphanet Journal of Rare Diseases. 2(21)
[Journal article]Authored by: Stowell, K.
Stowell, KM., Pollock, N., & Langton, E. (2007). Perinatal diagnosis of malignant hyperthermia susceptibility. Anaesthesia and Intensive Care. 35(3), 454-455
[Journal article]Authored by: Stowell, K.
Pollock, N., Langton, E., McDonnell, N., Tiemessen, J., & Stowell, K. (2006). Malignant hyperthermia and day stay surgery. Anaesthesia and Intensive Care. 34(1), 40-45
[Journal article]Authored by: Stowell, K.
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Pollock, N., Langton, E., Stowell, KM., Simpson, C., & McDonnell, N. (2004). Safe duration of postoperative monitoring for malignant hyperthermia susceptible patients. Anaesthesia and Intensive Care. 32(4), 502-509
[Journal article]Authored by: Stowell, K.
Davis, M., Brown, RL., Dickson, A., Horton, H., James, D., Laing, N., . . . Stowell, KM. (2002). Malignant hyperthermia associated with exercise-induced rhabdomyolysis or congenital abnormalities and a novel RYR1 mutation in New Zealand and Australian pedigrees. British Journal of Anaesthesia. 88(4), 508-515
[Journal article]Authored by: Brown, R., Stowell, K.
Pollock, AN., Langton, E., Couchman, KG., Stowell, KM., & Waddington, M. (2002). Suspected malignant hyperthermia reactions in New Zealand. Anaesth Intensive Care. 30(4), 453-461
[Journal article]Authored by: Stowell, K.
Chamley, D., Pollock, AN., Stowell, KM., & Brown, RL. (2000). Malignant hyperthermia in infancy and identification of novel RYR1 mutation. British Journal of Anaesthesia. 84(4), 500-504
[Journal article]Authored by: Brown, R., Stowell, K.
Brown, RL., Neil Pollock, A., Couchman, KG., Hodges, M., Hutchinson, DO., Waaka, R., . . . Stowell, KM. (2000). A novel ryanodine receptor mutation and genotype-phenotype correlation in a large malignant hyperthermia New Zealand Maori pedigree. Human Molecular Genetics. 9(10), 1515-1524
[Journal article]Authored by: Brown, R., Stowell, K.
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Funnell, APW., Wilson, MD., Ballester, B., Mak, KS., Burdach, J., Magan, N., . . . Crossley, M. (2013). A CpG mutational hotspot in a ONECUT binding site accounts for the prevalent variant of hemophilia B leyden. American Journal of Human Genetics. 92(3), 460-467
[Journal article]Authored by: Stowell, K.
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Chong, ESL., Mcghie, TK., Heyes, JA., & Stowell, KM. (2013). Metabolite profiling and quantification of phytochemicals in potato extracts using ultra-high-performance liquid chromatography-mass spectrometry. Journal of the Science of Food and Agriculture.
[Journal article]Authored by: Heyes, J., Stowell, K.
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Richter, S., Richter, JP., Mehta, SY., Gribble, AM., Sutherland-Smith, AJ., Stowell, KM., . . . Wilson, WR. (2012). Expression and role in glycolysis of human ADP-dependent glucokinase. Molecular and Cellular Biochemistry. , 1-15
[Journal article]Authored by: Stowell, K., Sutherland-Smith, A.
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Magan, N., Isaacs, RJ., & Stowell, KM. (2012). Treatment with the PARP-inhibitor PJ34 causes enhanced doxorubicin-mediated cell death in HeLa cells. Anti-Cancer Drugs. 23(6), 627-637
[Journal article]Authored by: Magan, N., Stowell, K.
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Dittmer, KE., Howe, L., Thompson, KG., Stowell, KM., Blair, HT., & Cockrem, JF. (2011). Normal vitamin D receptor function with increased expression of 25-hydroxyvitamin D <inf>3</inf>-24-hydroxylase in Corriedale sheep with inherited rickets. Research in Veterinary Science. 91(3), 362-369
[Journal article]Authored by: Blair, H., Cockrem, J., Dittmer, K., Howe, L., Stowell, K.
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Williams, AO., Isaacs, RJ., & Stowell, KM. (2007). Down-regulation of human topoisomerase II alpha expression correlates with relative amounts of specificity factors Sp1 and Sp3 bound at proximal and distal promoter regions. BMC MOLECULAR BIOLOGY. 8,
[Journal article]Authored by: Stowell, K.
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Koehn, H., Magan, N., Isaacs, RJ., & Stowell, KM. (2007). Differential regulation of DNA repair protein Rad51 in human tumour cell lines exposed to doxorubicin. Anti-Cancer Drugs. 18(4), 419-425
[Journal article]Authored by: Stowell, K.
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Allen, KA., Williams, AO., Isaacs, RJ., & Stowell, KM. (2004). Down-regulation of human topoisomerase IIα correlates with altered expression of transcriptional regulators NF-YA and Sp1. Anti-Cancer Drugs. 15(4), 357-362
[Journal article]Authored by: Stowell, K.
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(2003). Modulation of DNA topoisomerase IIα promoter activity by members of the Sp (specificity protein) and NF-Y (nuclear factor Y) families of transcription factors. Biochemical Journal. 374(3), 723-729
[Journal article]Authored by: Stowell, K.
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Tong, XZ., Zhang, X., Plummer, KM., Stowell, KM., Sullivan, PA., & Farley, PC. (2007). GcSTUA, an APSES transcription factor, is required for generation of appressorial turgor pressure and full pathogenicity of Glomerella cingulata. Molecular Plant-Microbe Interactions. 20(9), 1102-1111
[Journal article]Authored by: Stowell, K.
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Okeoma, CM., Stowell, KM., Williamson, NB., & Pomroy, WE. (2005). Neospora caninum: Quantification of DNA in the blood of naturally infected aborted and pregnant cows using real-time PCR. Experimental Parasitology. 110(1), 48-55
[Journal article]Authored by: Stowell, K.
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Tweedie, JW., & Stowell, KM. (2005). Quantification of DNA by agarose gel electrophoresis and analysis of the topoisomers of plasmid and M13 DNA following treatment with a restriction endonuclease or DNA topoisomerase I. Biochemistry and Molecular Biology Education. 33(1), 28-33
[Journal article]Authored by: Stowell, K.
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Okeoma, CM., Williamson, NB., Pomroy, WE., & Stowell, KM. (2004). Recognition patterns of Neospora caninum tachyzoite antigens by bovine IgG at different IFAT titres. Parasite Immunology. 26(4), 177-185
[Journal article]Authored by: Stowell, K.
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Okeoma, CM., Williamson, NB., Pomroy, WE., Stowell, KM., & Gillespie, L. (2004). The use of PCR to detect Neospora caninum DNA in the blood of naturally infected cows. Veterinary Parasitology. 122(4), 307-315
[Journal article]Authored by: Stowell, K.
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Okeoma, CM., Williamson, NB., Pomroy, WE., Stowell, KM., & Gillespie, LM. (2004). Isolation and molecular characterisation of neospora caninum in cattle in New Zealand. New Zealand Veterinary Journal. 52(6), 364-370
[Journal article]Authored by: Stowell, K.
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Day, CL., Stowell, KM., Baker, EN., & Tweedie, JW. (1992). Studies of the N-terminal half of human lactoferrin produced from the cloned cDNA demonstrate that interlobe interactions modulate iron release. Journal of Biological Chemistry. 267(20), 13857-13862
[Journal article]Authored by: Stowell, K.
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Page, RA., Stowell, KM., Hardman, MJ., & Kitson, KE. (1992). The assessment of viability in isolated rat hepatocytes. Analytical Biochemistry. 200(1), 171-175
[Journal article]Authored by: Page, R., Stowell, K.
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Stowell, KM., Rado, TA., Funk, WD., & Tweedie, JW. (1991). Expression of cloned human lactoferrin in baby-hamster kidney cells. Biochemical Journal. 276(2), 349-355
[Journal article]Authored by: Stowell, K.
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CROW, KE., STOWELL, KM., & HARDMAN, MJ. (1986). RELATIONSHIP BETWEEN ETHANOL OXIDATION RATE AND [LACTATE] [PYRUVATE] IN ISOLATED RAT HEPATOCYTES. ALCOHOL AND ALCOHOLISM. 21(2), A24-A24
[Journal article]Authored by: Stowell, K.
Stowell, KM., & Crow, KE. (1985). The effect of acute ethanol treatment on rates of oxygen uptake, ethanol oxidation and gluconeogenesis in isolated rat hepatocytes. Biochemical Journal. 230(3), 595-602
[Journal article]Authored by: Stowell, K.
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Willis, JA., Stowell, KM., Crow, KE., Batt, RD., & Hardman, MJ. (1985). Increased malate dehydrogenase activity in blood from non-drinking alcoholics. Alcohol and Alcoholism. 20(3), 293-298
[Journal article]Authored by: Stowell, K.
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STOWELL, KM., CROW, KE., & HARDMAN, MJ. (1984). THE EFFECT OF ACUTE ETHANOL TREATMENT ON OXYGEN-CONSUMPTION IN ISOLATED HEPATOCYTES. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. 8(1), 121-121
[Journal article]Authored by: Stowell, K.
Crow, KE., Newland, KM., & Batt, RD. (1983). Factors influencing rates of ethanol oxidation in isolated rat hepatocytes. Pharmacology, Biochemistry and Behavior. 18(SUPPL. 1), 237-240
[Journal article]Authored by: Stowell, K.
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CROW, KE., NEWLAND, KM., & BATT, RD. (1982). FACTORS INFLUENCING RATES OF ETHANOL OXIDATION IN ISOLATED RAT HEPATOCYTES. ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH. 6(2), 293-293
[Journal article]Authored by: Stowell, K.
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Crow, KE., & Newland, KM. (1981). The Fructose Effect. The New Zealand medical journal. 93, 232-240
[Journal article]Authored by: Stowell, K.

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Creative Work

Stowell, K.(2009). Malignant hyperthermia: An educational resource. [DVD]. : New Zealand Society of Anaesthetist
[Film or Video]Authored by: Stowell, K.

Conference

Schiemann, AH. (2018, August). Functional characterisation of RYR1 variants using immortalized myoblasts. Presented at Palmerston North Medical Research Foundation Colloquium 2018
[Conference Oral Presentation]Authored by: Schiemann, A., Stowell, K.
Stephens, J., Stowell, KM., Schiemann, AH., & Sutherland-Smith, A. (2018). Characterisation of malignant hyperthermia associated RyR1 variants. Poster session presented at the meeting of Gage Muscle Conference, Canberra. Canberra, Australia
[Conference Poster]Authored by: Schiemann, A., Stowell, K., Sutherland-Smith, A.Contributed to by: Schiemann, A.
Schiemann, AH., Parker, R., & Stowell, KM. (2018, April). Identification and characterisation of variants associated with malignant hyperthermia in New Zealand families. Presented at Gage Conference Muscle 2018. Canberra, Australia.
[Conference Oral Presentation]Authored by: Schiemann, A., Stowell, K.
Stowell, K., Schiemann, A., Bulger, T., Pollock, N., Bjorksten, A., & Gillies, R. (2017, May). A common RYR1 variant in linkage disequilibrium with a repeat element in DMPK associated with myotonic dystrophy. Presented at European Malignant Hyperthermia Group, 36th meeting. Antwerp, Belgium.
[Conference Oral Presentation]Authored by: Schiemann, A., Stowell, K.
Sullivan, KL., Stowell, KM., Pain, SJ., Kenyon, PR., & Blair, HT. (2016). Does dam age effect gene expression in fetal and young sheep?. , Australian Society of Animal Production
[Conference Abstract]Authored by: Blair, H., Kenyon, P., Pain, S., Stowell, K.

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Parker,, RJ., Stowell, KM., Schiemann, AH., & Rhodes, L. (2015). Functional analysis of RyR1 transmembrane domain variants. Poster session presented at the meeting of Gordon Research Seminar (GRS) Muscle: Excitation-contraction coupling. United States of America
[Conference Poster]Authored by: Schiemann, A., Stowell, K.
Schiemann, AH., & Stowell, KM. (2015). Targeted DNA capture and NGS to identify mutations associated with malignant hyperthermia. Poster session presented at the meeting of Gordon Research Conference (GRC): Muscle: Excitation-Contraction Coupling. Newry, United States of America
[Conference Poster]Authored by: Schiemann, A., Stowell, K.
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Stowell, KM., Langton, E., Pollock, N., & Schiemann, AH. (2014). Targeted exon capture and NGS to investigate an undefined myopathy reveal RYR1 variants. In BMC Anesthesiology Vol. Suppl 1 (pp. A15 - A15). , 33rd Annual Meeting of the European Malignant Hyperthermia Group (EMHG): Springer Nature
[Conference Abstract]Authored by: Schiemann, A., Stowell, K.Contributed to by: Schiemann, A.
Stowell, K.(2008). Chairperson, Session 2. . Lund, Sweden
[Conference Other]Authored by: Stowell, K.
Schiemann, AH., & Stowell, KM. (2011). Sequence capture and massively parallel sequencing to detect mutations associated with Malignant Hyperthermia. Poster session presented at the meeting of New Zealand Next Generation Sequencing Conference. Palmerston North
[Conference Poster]Authored by: Schiemann, A., Stowell, K.
Merritt, A., Booms, P., Fisher, N., Duke, AM., Sato, K., Kim, J., . . . Hopkins, PM.(2012, June). Functional analysis of the p.D1056H RYR1 variant associated with malignant hyperthermia and exertional heat stroke. BRITISH JOURNAL OF ANAESTHESIA. 109 (4)(pp. 663P - 663P). 0007-0912.
[Conference]Authored by: Stowell, K.
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Richter, S., Patterson, AV., Stowell, KM., Ronimus, RS., & Wilson, WR.(2011, September). Evaluation of the Role of the Novel Glucose-phosphorylating Enzyme ADP-dependent Glucokinase In Human Tumour Cell Lines Using Zinc Finger Nuclease Gene Knockouts. EUROPEAN JOURNAL OF CANCER. (pp. S101 - S101). 0959-8049.
[Conference]Authored by: Stowell, K.
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Schiemann, AH., & Stowell, KM. (2011, August). Sequence capture and massively parallel sequencing to detect mutations associated with Malignant Hyperthermia. Presented at New Zealand Next Generation Sequencing Conference. Palmerston North.
[Conference Oral Presentation]Authored by: Schiemann, A., Stowell, K.
Merritt, A., Booms, P., Duke, A., Sato, K., Stowell, K., Steele, D., . . . Hopkins, P. (2011). The p.D3986E RYR1 mutation may not be causative of malignant hyperthermia. , 30th Annual European Malignant Hyperthermia Group
[Conference Abstract]Authored by: Stowell, K.
Stowell, K., & Schiemann, A. (2011). Exon-capture and massively parallel sequencing to identify a "new" MH gene. , 30th Annual European Malignant Hyperthermia Group
[Conference Abstract]Authored by: Schiemann, A., Stowell, K.
Stowell, K. (2011, February). Malignant hyperthermia: the ryanodine receptor and beyond. Presented at 10th Annual Scientific Meeting of the Asian Oceanian Myology Center. Auckland, New Zealand.
[Conference Oral Presentation]Authored by: Stowell, K.
Stowell, K., Schiemann, A., & Paul, N. (2011). In search of a new "Hot" gene. Poster session presented at the meeting of 32nd Lorne Genome Conference. Lorne, VIC, Australia
[Conference Poster]Authored by: Schiemann, A., Stowell, K.
Sullivan, K., Stowell, K., Pain, S., & Blair, H. (2010). Expression of leptin, leptin receptor, insulin, insulin receptor, and GLUT4 in the offspring of adolescent mammals. In National Research Centre for Growth and Development 2010 Science Symposium(pp. 36 - 36). : National Research Centre for Growth and Development
[Conference Abstract]Authored by: Pain, S., Stowell, K.
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Sullivan, K., Stowell, K., Pain, S., & Blair, H. (2010). Expression of leptin, leptin receptor, insulin, insulin receptor, and GLUT4 in the offspring of adolescent mammals. Poster session presented at the meeting of National Research Centre for Growth and Development [NRCGD] 2010 Science Symposium. Auckland, New Zealand
[Conference Poster]Authored by: Blair, H., Pain, S., Stowell, K.
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Merritt, A., Booms, P., Duke, A., Sato, K., Stowell, K., Steele, D., . . . Hopkins, PM. (2010). Functional analysis of the p.Gly3990Val RYR1 variant using a human cDNA clone in HEK293 cells. In BRITISH JOURNAL OF ANAESTHESIA Vol. 105 (pp. 718 - 718). , Annual Meeting of the Anaesthetic-Research-Society: OXFORD UNIV PRESS
[Conference Abstract]Authored by: Stowell, K.
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Stowell, K. (2009, December). Malignant hyperthermia: A killer while you sleep?. Presented at Combio Christchurch Convention Centre. Christchurch, New Zealand.
[Conference Oral Presentation]Authored by: Stowell, K.
Stowell, K. (2009, April). DNA testing for MH: Is it worth it?. Presented at European Malignant Hyperthermia Group. Mornington Peninsula, VIC, Australia.
[Conference Oral Presentation]Authored by: Stowell, K.
Dittmer, KE., Thompson, KG., Howe, LJ., Stowell, KM., & Blair, HT. (2009, August). Behind the bendy bones: Investigating inherited rickets in Corriedale sheep. Presented at Palmerston North Medical Research Foundation Colloquium. Palmerston North, New Zealand.
[Conference Oral Presentation]Authored by: Blair, H., Dittmer, K., Howe, L., Stowell, K.
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Dittmer, K., Thompson, K., Howe, L., Blair, HT., & Stowell, K. (2008, November). Inherited rickets in Corriedale sheep. Presented at Combined 59th and 43rd Annual Meeting of the American College of Veterinary Pathologists and the American Society for Veterinary Clinical Pathology. San Antonio, TX, United States.
[Conference Oral Presentation]Authored by: Blair, H., Dittmer, K., Howe, L., Stowell, K.
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Grievink, A., & Stowell, K. (2008, May). Allele specific expression of the ryanodine receptor 1. Presented at 27th Annual Meeting of the European Malignant Hyperthermia Group. Lund, Sweden.
[Conference Oral Presentation]Authored by: Stowell, K.
Sato, K., & Stowell, K. (2008, May). Functional analyses of RYR1 mutations causing malignant hyperthermia and central core disease using human RYR1 cDNA. Presented at 27th Annual Meeting of the European Malignant Hyperthermia Group. Lund, Sweden.
[Conference Oral Presentation]Authored by: Stowell, K.
Marston, R., & Stowell, K. (2008, May). A de novo homozygous T4826I mutation??. Presented at 27th Annual Meeting of the European Malignant Hyperthermia Group. Lund, Sweden.
[Conference Oral Presentation]Authored by: Stowell, K.
Stowell, K. (2008, May). When can we stop using the IVCT for diagnosis of MH susceptibility?. Presented at 27th Annual Meeting of the European Malignant Hyperthermia Group. Lund, Sweden.
[Conference Oral Presentation]Authored by: Stowell, K.
Byrne, T., Blair, H., Thompson, K., Stowell, K., & Piripi, S. (2008). Inheritance of chondrodysplasia in Texel sheep. Proceedings of the 68th New Zealand Society of Animal Production. Vol. 68 (pp. 20 - 22). New Zealand: 68th New Zealand Society of Animal Production Conference
[Conference Paper in Published Proceedings]Authored by: Blair, H., Stowell, K.
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Dittmer, K., Thompson, K., Howe, L., Blair, H., & Stowell, K. (2008). Inherited rickets in corriedale sheep. In Veterinary Pathology Vol. 45 (pp. 771 - 771). , Combined 59th and 43rd Annual Meeting of the American College of Veterinary Pathologists and the American Society for Veterinary Clinical Pathology United States: American College of Veterinary Pathologists Inc and SAGE Publishing
[Conference Abstract]Authored by: Blair, H., Dittmer, K., Howe, L., Stowell, K.
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Stowell, K., Isaacs, R., Williams, A., Magan, N., & Aalderink, M. (2007). Determinants of drug sensitivity in breast cancer. Poster session presented at the meeting of Queenstown Molecular Biology Cancer Satellite Meeting. Queenstown, New Zealand
[Conference Poster]Authored by: Stowell, K.
Stowell, K. (2007, November). Malignant hyperthermia in New Zealand: Progress and problems. Presented at NZMS-NZSBMB Annual Conference from molecules to complex systems. Victoria University, Wellington.
[Conference Oral Presentation]Authored by: Stowell, K.
Stowell, K. (2007, July). Drug resistance to doxorubicin: How important is topoisomerase II?. Presented at Signal transduction symposium. University of Auckland.
[Conference Oral Presentation]Authored by: Stowell, K.
Tong, XZ., Stowell, KM., & Farley, PC. (2006). Cloning and characterisation of a transcription factor GC-ZXT in Glomerella cingulata. Poster session presented at the meeting of 8th International Mycological Congress. Cairns, QLD
[Conference Poster]Authored by: Stowell, K.
Okeoma, CM., Williamson, NB., Pomroy, WE., Stowell, KM., & Gillespie, L. (2005). Further studies on Neospora caninum including its isolation in New Zealand and the first isolation of circulating N. caninum DNA in cattle. In New Zealand Journal of Zoology Vol. 32 (pp. 277). Wellington, NZ: Royal Society of New Zealand
[Conference Abstract]Authored by: Stowell, K.
Thompson, KG., Blair, HT., Piripi Ellicott, SA., Dittmer, KE., Firth, EC., & Stowell, KM. (2005). Skeletal research in the pathobiology group. (pp. 7). , Institute of Veterinary, Animal and Biomedical Sciences Research Colloquium Palmerston North, NZ: Massey University
[Conference Abstract]Authored by: Blair, H., Stowell, K.
Okeoma, CM., Williamson, NB., Pomroy, BE., Stowell, KM., & Gillespie, L. (2005). Further studies on Neospora caninum including its isolation in New Zealand and the first isolation of circulating N. caninum DNA in cattle. In New Zealand Journal of Zoology Vol. 32 (pp. 277 - 277). Wellington, NZ: The Royal Society of New Zealand
[Conference Abstract]Authored by: Stowell, K.
Williams, AO., Koehn, H., Isaacs, RJ., & Stowell, KM. (2004). Drug resistance in breast cancer cells. (pp. 57 - 57). , The Fourteenth Annual Queenstown Molecular Biology Meeting: New Zealand Society for Biochemistry and Molecular Biology
[Conference Abstract]Authored by: Stowell, K.
Isaacs, RJ., & Stowell, KM. (2004, June). Translational research in Palmerston North. Presented at New Zealand Society for Oncology Conference. Christchurch, NZ.
[Conference Oral Presentation]Authored by: Stowell, K.
Okeoma, CM., Williamson, NB., Pomroy, BE., Stowell, KM., & Gillespie, L. (2004, November). Further studies on Neospora caninum including its isolation in New Zealand and the first isolation of circulating N. caninum DNA in cattle. Presented at 32nd New Zealand Society for Parasitology Annual Meeting. Massey University, Palmerston North, NZ.
[Conference Oral Presentation]Authored by: Stowell, K.
Williamson, NB., Okeoma, CM., Pomroy, BE., Stowell, KM., & Gillespie, L. (2004). A study to investigate the influence of bovine virus diarrhoea on pregnant heifers infected with Neospora caninum and the first identification of circulating N. caninum DNA in cattle. (pp. 41 - 41). , 23rd World Buiatrics Congress Quebec, QC: World Association for Buiatrics
[Conference Abstract]Authored by: Stowell, K.
Williams, AO., Koehn, H., Isaacs, RJ., & Stowell, KM. (2004). Drug resistance in breast cancer cells. Poster session presented at the meeting of 14th Annual Queenstown Molecular Biology Meeting. Queenstown, NZ
[Conference Poster]Authored by: Stowell, K.
Tong, XZ., Plummer, KM., Stowell, KM., Sullivan, PA., & Farley, PC. (2004). Cloning and characterisation of a transcription factor GC-ZXT in Glomerella cingulata. Poster session presented at the meeting of New Zealand Microbiology Society Annual Conference. Palmerston North, NZ
[Conference Poster]Authored by: Stowell, K.
Farley, PC., Tong, XZ., Clark, SJ., Templeton, MD., Plummer, KM., Stowell, KM., . . . Sullivan, PA. (2002). Analysis of the Glomerella cingulata secreted aspartic peptidase gene and its expression during appressorium formation. Poster session presented at the meeting of 6th European Conference on Fungal Genetics. Palazzo dei Congressi, Pisa, ITA
[Conference Poster]Authored by: Stowell, K.
Tong, XZ., Clark, SJ., Templeton, MD., Plummer, KM., Stowell, KM., Sullivan, PA., . . . Farley, PC. (2001). Analysis of the Glomerella cingulata secreted aspartic peptidase gene and its expression during appressorium formation. Poster session presented at the meeting of New Zealand Institute of Chemistry (NZIC), New Zealand Society for Biochemistry and Molecular Biology (NZSBMB), and New Zealand Biotechnology Association (NZBA) Conference 2001: Molecules for Life. Marine Parade, Napier, NZ
[Conference Poster]Authored by: Stowell, K.
Tweedie, JW., Bain, HB., Day, CL., Nicholson, HH., Mead, PE., Sheth, B., . . . Stowell, KM.Lactoferrin cDNA: Expression and in vitro mutagenesis. Advances in Experimental Medicine and Biology. (pp. 197 - 208). 0065-2598.
[Conference]Authored by: Stowell, K.
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Sheth, B., Stowell, KM., Day, CL., Baker, EN., & Tweedie, JW.Cloning and expression of the C-terminal lobe of human lactoferrin. Advances in Experimental Medicine and Biology. (pp. 259 - 263). 0065-2598.
[Conference]Authored by: Stowell, K.
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Other

Schiemann, AH., & Stowell, KM. (2015, August). Functional analysis of mutations associated with Malignant Hyperthermia. In Palmerston North Medical Research Foundation (PNMRF) Colloquium.
[Oral Presentation]Authored by: Schiemann, A., Stowell, K.
Stowell, KM.Malignant Hyperthermia: In Search of a Hot New Gene.
[Oral Presentation]Authored by: Stowell, K.
Read Abstract: abstract icon
Stowell, KM.Malignant Hyperthermia: Genetic and Biochemical Analysis.
[Oral Presentation]Authored by: Stowell, K.
Dittmer, KE., Thompson, KG., Howe, LJ., Stowell, KM., & Blair, HT. (2007, November). Inherited rickets in corriedale sheep - unlocking the mechanism. In Medical Research Foundation Colloquium, Palmerston North, New Zealand.
[Oral Presentation]Authored by: Blair, H., Dittmer, K., Howe, L., Stowell, K.
Read Abstract: abstract icon

Teaching and Supervision

Teaching Statement

  • Metabolic Biochemistry
  • Biochemistry of the rumen
  • Regulation of prokaryotic gene expression
  • DNA/protein interactions
  • DNA Topology
  • Detection and analysis of DNA polymorphisms
  • Recombinant DNA technology
  • Splicing and processing of eukaryotic transcripts
  • Post transcriptional regulation of gene expression
  • Regulation of eukaryotic gene expression
  • Regulation of gene expression by non-coding RNAs

Courses Coordinated

Contact Supervisor

Graduate Supervision Statement

I operate an “open-door” policy for my graduate students encouraging them to discuss experimental results and any potential problems as they occur.  The intention here is to instill in the graduate student the ability to assimilate data, critically analyse it and ultimately “take charge” of their individual project as early in the programme as possible.  As some graduate students need to use shared biological resources there are ample opportunities to develop and implement teamwork strategies and skills.  To this end weekly research meetings are held with all laboratory personnel to formally present work in progress and informally discuss successes and failures.  This encourages interaction between students and research staff and assists in gaining confidence in both formal and informal presentation of work.

Graduate students themselves always prepare the first draft of any manuscript that may arise from the research work and I have acted as an effective mentor in a range of different subject areas that has ultimately led to publication.  The ultimate aim is to produce a self-critical graduate who can enter their chosen career with a sound background in appropriate scientific method, with the confidence to critically develop their own ideas, challenge others and be an independent and successful researcher.  


Prof Kathryn Stowell is not currently available for Masters or Doctoral supervision.

Summary of Doctoral Supervision

Position Current Completed
Main Supervisor 1 9
Co-supervisor 0 14

Current Doctoral Supervision

Main Supervisor of:

  • Sophie Burling - Doctor of Philosophy
    Innervated "muscle-on-a-chip" for diagnostics and research of neuromuscular disorders

Completed Doctoral Supervision

Main Supervisor of:

  • 2021 - Jeremy Stephens - Doctor of Philosophy
    Establishing systems to characterise MH pathogenic RyR1 variants
  • 2019 - Remai Parker - Doctor of Philosophy
    Functional consequences of RyR1 variants
  • 2013 - Cornelia Roesl - Doctor of Philosophy
    Functional and structural characterisation of the Malignant Hyperthermia associated RYR1 mutation R2452W
  • 2013 - Sarah Taylor - Doctor of Philosophy
    Novel models of tendon injury and gap junction modulation in tendon cell and tissue repair
  • 2012 - Roger Watkins - Doctor of Philosophy
    The Biogeographym Ecology and Endophyte mycorrhiza of the New Zealand Corybas Alliance (orchidaceae)
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  • 2010 - Keisaku Sato - Doctor of Philosophy
    A functional analysis of RYRI mutations causing malignant hyperthermia
  • 2010 - Natisha Magan - Doctor of Philosophy
    Protein interactions at the human topoisomerase II alpha promoter
  • 2009 - Albert Grievink - Doctor of Philosophy
    Malignant hyperthermia: Allele specific expression and mutation screening of the ryanodine receptor 1
  • 2006 - Henning Koehn - Doctor of Philosophy
    Reduction in ChemoSensitivity with Breast Cancer Chemotheraphy.
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Co-supervisor of:

  • 2019 - Marina Rajic - Doctor of Philosophy
    Development and applications of filamentous phage-derived particles in immunotherapy and diagnostics
  • 2018 - Aakansha Kanojia - Doctor of Philosophy
    Stress-adapation and ageing is controlled by senescence-inducing age related changes in Arabidopsis thaliana
  • 2017 - Silvia Schwartz - Doctor of Philosophy
    Investigating the role of Histone Deacetylase HDAC4 in long-term memory formation
  • 2017 - Sarah Bond - Doctor of Philosophy
    Histone H1 phosphorylation during mitosis
  • 2015 - Rebecca Smith - Doctor of Philosophy
    ATM and p400: Characterisation of a novel interaction between a DNA repair enzyme and a chromatin remodeler
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  • 2014 - Sadia Sattar - Doctor of Philosophy
    Filamentous phage-derived nano-rods for applications in diagnostics and vaccines
  • 2014 - Jan Richter - Doctor of Philosophy
    Structure and function of the eukaryotic ADP-dependent glucokinase
  • 2013 - Swee Chong - Doctor of Philosophy
    Phytochemical-rich potato extracts and potential for risk reduction in tamoxifen treatment of breast cancer
  • 2010 - Corey Laverty - Doctor of Philosophy
    The importance of the promoter in Drosophila dosage compensation
  • 2009 - Keren Dittmer - Doctor of Philosophy
    Inherited Rickets in Corriedale Sheep
  • 2007 - Xingzhang Tong - Doctor of Philosophy
    Transcriptional regulation of appressorium formation and function in Glomerella Cingulata.
  • 2006 - Chioma Okeoma - Doctor of Philosophy
    Studies on Neospora Caninum and Neosporosis in New Zealand
  • 2005 - Vikki Weake - Doctor of Philosophy
    The x-linked #LSP1a# Gene of #Drosphila Melanogaster# is not Acetylated by MOF, but is sex-specifically Regulated by Individual Components of the MSL Complex.
  • 1996 - Heather Bain - Doctor of Philosophy
    Isolation and Characterisation of the 5' region of the Bovine Lactoferrin Gene

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