122303

Gene Regulation

The course explores gene regulation in eukaryotes from nuclear organisation to cytosolic control, with a focus on animals and humans. The molecular mechanisms of transcription within a chromatin environment will be discussed, along with the role of RNA processing and post-transcriptional regulation in gene expression, and their importance to health and disease. A lecture and problem-based tutorial course complemented by a hands-on laboratory project undertaking experimental methods used to study gene expression.

Course code

Qualifications are made up of courses. Some universities call these papers. Each course is numbered using six digits.

122303

Level

The fourth number of the course code shows the level of the course. For example, in course 219206, the fourth number is a 2, so it is a 200-level course (usually studied in the second year of full-time study).

300-level

Credits

Each course is worth a number of credits. You combine courses (credits) to meet the total number of credits needed for your qualification.

15

Subject

Biochemistry

Course planning information

Course notes

The final examination will be an online supervised examination using remote invigilation.

Submission of assignments and attendance at tests and all the laboratory classes is compulsory. To pass the course students must achieve a minimum of 43% in the final exam.

Prerequisite courses

Complete first
122202 or 122233 or 122231 or 203240 or 203211 or 203300 or 203310

You need to complete the above course or courses before moving onto this one.

General progression requirements

You must complete at least 45 credits from 200-level before enrolling in 300-level courses.

Learning outcomes

What you will learn. Knowledge, skills and attitudes you’ll be able to show as a result of successfully finishing this course.

  • 1 Describe and explain the three-dimensional dynamic structure of the eukaryotic genome.
  • 2 Describe and critically discuss chromatin structure and function, and epigenetic mechanisms as they apply to transcriptional regulation and gene expression in both health and disease.
  • 3 Describe and critically discuss RNA processing and post-transcriptional mechanisms of gene regulation.
  • 4 Describe and explain contemporary experimental approaches for investigating gene expression.
  • 5 Carry out and critically interpret experiments to investigate molecular mechanisms of eukaryote gene regulation at the DNA, RNA and protein level.

Learning outcomes can change before the start of the semester you are studying the course in.

Assessments

Assessment Learning outcomes assessed Weighting
Written Assignment 5 20%
Test 1 2 4 10%
Portfolio 4 5 20%
Exam (centrally scheduled) 1 2 3 4 50%

Assessment weightings can change up to the start of the semester the course is delivered in.

You may need to take more assessments depending on where, how, and when you choose to take this course.

Explanation of assessment types

Computer programmes
Computer animation and screening, design, programming, models and other computer work.
Creative compositions
Animations, films, models, textiles, websites, and other compositions.
Exam College or GRS-based (not centrally scheduled)
An exam scheduled by a college or the Graduate Research School (GRS). The exam could be online, oral, field, practical skills, written exams or another format.
Exam (centrally scheduled)
An exam scheduled by Assessment Services (centrally) – you’ll usually be told when and where the exam is through the student portal.
Oral or performance or presentation
Debates, demonstrations, exhibitions, interviews, oral proposals, role play, speech and other performances or presentations.
Participation
You may be assessed on your participation in activities such as online fora, laboratories, debates, tutorials, exercises, seminars, and so on.
Portfolio
Creative, learning, online, narrative, photographic, written, and other portfolios.
Practical or placement
Field trips, field work, placements, seminars, workshops, voluntary work, and other activities.
Simulation
Technology-based or experience-based simulations.
Test
Laboratory, online, multi-choice, short answer, spoken, and other tests – arranged by the school.
Written assignment
Essays, group or individual projects, proposals, reports, reviews, writing exercises, and other written assignments.

Textbooks needed

Textbooks can change. We recommend you wait until at least seven weeks before the semester starts to buy your textbooks.

Highly recommended

MOLECULAR BIOLOGY

Author
WEAVER
ISBN
978007352532
Edition
5TH
Publisher
MCGRAW HILL
Notes
EBOOK available from supplier website

Recommended

MOLECULAR CELL BIOLOGY

Author
LODISH ET AL.
ISBN
9781464183393
Edition
8TH
Publisher
Macmillan

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