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Jan Richter

Doctor of Philosophy, (Biochemistry)
Study Completed: 2014
College of Sciences

Citation

Thesis Title
Structure and function of the eukaryotic ADP-dependent glucokinase

Read article at Massey Research Online: MRO icon

Mr Richter’s work investigated the structure and function of the eukaryotic ADP-dependent glucokinase (ADPGK). This enzyme is well studied in archaea, where ADPGK is part of a set of glycolytic enzymes that use ADP instead of ATP for the phosphorylation of various sugars. However, ADPGK has also been found in eukaryotes, including humans. While crystal structures of the archaeal enzymes were known prior to this work, no structure of a eukaryotic ADPGK had been solved. In this thesis, the kinetic analysis of human ADPGK and the crystal structure of mouse ADPGK are presented, contributing to our understanding of the biological role of this enzyme in eukaryotes. 

Supervisors
Associate Professor Andrew Sutherland-Smith
Dr Ron Ronimus
Professor Kathryn Stowell

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