Contact details +64 (06) 356 9099  ext. 84741

Dr Tracy Hale

Senior Lecturer

Institute of Fundamental Sciences

Professional

Contact details

  • Location: ScC2.06
    Campus: Turitea

Research Expertise

Research Interests

Chromatin Biology

Cancer Biology

Thematics

Health and Well-being

Area of Expertise

Field of research codes
Biochemistry and Cell Biology (060100): Biological Sciences (060000):
Cancer Cell Biology (111201):
Cell and Nuclear Division (060402): Epigenetics (incl. Genome Methylation and Epigenomics) (060404): Genetics (060400):
Medical And Health Sciences (110000): Oncology and Carcinogenesis (111200)

Research Projects

Summary of Research Projects

Position Current Completed
Project Leader 3 11

Current Projects

Project Title: Targeting HP1 regulated pathways to suppress breast cell invasion

Date Range: 2016 - 2018

Funding Body: Health Research Council of New Zealand

Project Team:

Research Outputs

Journal

Contreras, A., Hale, TK., Stenoien, DL., Rosen, JM., Mancini, MA., & Herrera, RE. (2003). The Dynamic Mobility of Histone H1 Is Regulated by Cyclin/CDK Phosphorylation. Molecular and Cellular Biology. 23(23), 8626-8636
[Journal article]Authored by: Hale, T.
Hale, TK., Norris, GE., Jameson, GB., & Filichev, VV. (2014). Helicases, G4-DNAs, and drug design. ChemMedChem. 9(9), 2031-2034
[Journal article]Authored by: Filichev, V., Hale, T., Jameson, G., Norris, G.
Tretiakova, MS., Bond, SD., Wheeler, D., Contreras, A., Kocherginsky, M., Kroll, TG., . . . Hale, TK. (2014). Heterochromatin protein 1 expression is reduced in human thyroid malignancy. Laboratory Investigation. 94(7), 788-795
[Journal article]Authored by: Hale, T.
Park, JH., Hale, TK., Smith, RJ., & Yang, T. (2014). PPM1B depletion induces premature senescence in human IMR-90 fibroblasts. Mechanisms of Ageing and Development. 138(1), 45-52
[Journal article]Authored by: Hale, T., Park, J.
Doluca, O., Hale, TK., Edwards, PJB., Gonzalez, C., & Filichev, VV. (2014). Assembly dependent fluorescence enhancing nucleic acids in sequence-specific detection of double-stranded DNA. ChemPlusChem. 79(1), 58-66
[Journal article]Authored by: Edwards, P., Filichev, V., Hale, T.
Clausell, J., Happel, N., Hale, TK., Doenecke, D., & Beato, M. (2009). Histone H1 subtypes differentially modulate chromatin condensation without preventing ATP-dependent remodeling by SWI/SNF or NURF. PLoS ONE. 4(10)
[Journal article]Authored by: Hale, T.
Mandhan, P., Beasley, S., Hale, TK., Ellmers, L., Roake, J., & Sullivan, M. (2006). Sonic hedgehog expression in the development of hindgut in ETU-exposed fetal rats. Pediatric Surgery International. 22, 31-36
[Journal article]Authored by: Hale, T.
Hale, TK., Contreras, A., Morrison, AJ., & Herrera, RE. (2006). Phosphorylation of the Linker Histone H1 by CDK Regulates Its Binding to HP1α. Molecular Cell. 22(5), 693-699
[Journal article]Authored by: Hale, T.
Hale, TK., & Mansfield, BC. (1989). Nucleotide sequence of a cDNA clone representing a third allele of human protein B23. Nucleic Acids Research. 17(23), 10112
[Journal article]Authored by: Hale, T.

Conference

Hale, TK. (2017, November). Untethering the genome - Loss of HP1a enhances malignant cell invasion. Presented at New Zealand Breast Cancer Symposium
[Conference Oral Presentation]Authored by: Hale, T.
Hale, TK., Bond, S., & Wheeler, D. (2017). Untethering heterochromatin: How loss of HP1a enhances cell invasion by altering nuclear envelope integrity. Poster session presented at the meeting of American Association of Cancer Research Annual Meeting. Washington, DC, United States of America
[Conference Poster]Authored by: Bond, S., Hale, T.
Lukito, Y., Chujo, T., Hale, TK., Johnson, LJ., & Scott, B. (2017). Regulation of Epichloë festucae secondary metabolite genes by CclA, KdmB and H3K4 trimethylation. Poster session presented at the meeting of QMB Plant-Microbe Interactions Satellite at Queenstown Research Week
[Conference Poster]Authored by: Hale, T., Scott, D.
Lukito, Y., Chujo, T., Hale, TK., Johnson, LJ., & Scott, B.Regulation of Epichloë festucae secondary metabolite genes by CclA, KdmB and H3K4 trimethylation. . Queenstown
[Conference Paper]Authored by: Hale, T., Scott, D.
Lukito, Y., Chujo, T., Hale, TK., Johnson, LJ., & Scott, B. (2017). Regulation of Epichloë festucae secondary metabolite genes by CclA, KdmB and H3K4 trimethylation. Poster session presented at the meeting of QMB Plant-Microbe Interactions Satellite at Queenstown Research Week. Queenstown
[Conference Poster]Authored by: Hale, T.
Cui, X., Stimpson, L., Hale, TK., & Contreras, A. (2016). Heterochromatin protein 1 alpha modulates the invasive potential of malignant cells. , American Association of Cancer Research Annual Meeting
[Conference Abstract]Authored by: Hale, T.
Lukito, Y., Chujo, T., Hale, T., Johnson, L., & Scott, B. (2016). Histone H3K4 methylation regulates biosynthesis of fungal anti-mammalian alkaloids in an endophyte-plant symbiosis. , Third Cold Spring Harbor Laboratory Meeting on Epigenetics & Chromatin
[Conference Abstract]Authored by: Hale, T., Scott, D.
Cheng, L., Hale, TK., & Tretiakova, MS.Expression of Heterochromatin Protein 1 in Renal Cortical Tumors and Identification of Its Target Genes. LABORATORY INVESTIGATION. (pp. 221A - 221A). 0023-6837.
[Conference]Authored by: Hale, T.
Cheng, L., Hale, TK., & Tretiakova, MS.(2016, February). Expression of Heterochromatin Protein 1 in renal cortical-tumors and identification of its target genes. MODERN PATHOLOGY. (pp. 221A - 221A). 0893-3952.
[Conference]Authored by: Hale, T.
Bond, S., & Hale, TK. (2014). Phosphorylation of Histone H1.4 by Aurora B is required for the proper execution of Mitosis. Poster session presented at the meeting of Gordon Conference on Chromatin Structure and Function, Boston, USA. Boston, United States of America
[Conference Poster]Authored by: Hale, T.Contributed to by: Hale, T.
Hale, TK. (2013, September). Heterochromatin Protein 1 in Cancer. Presented at Queenstown Molecular Biology Meeting Epigenetics Satellite Meeting
[Conference Oral Presentation]Authored by: Hale, T.
Hale, TK. (2011, September). The role of histone H1 and HP1 in tumorigensis. Presented at QMB Epigenetics Satellite Meeting. Queenstown, New Zealand.
[Conference Oral Presentation]Authored by: Hale, T.
Hale, TK., & Bond, S. (2010). Aurora B Phosphorylates Histone H1 During Mitosis. Poster session presented at the meeting of Queenstown Molecular Biology Meeting. Queenstown, New Zealand
[Conference Poster]Authored by: Hale, T.
Contreras, A., Gutierrez, MC., & Hale, TK.(2010, March). Differential Expression Patterns of the Heterochromatin Proteins HP1 alpha and HP1 beta in Different Tumor Types. LABORATORY INVESTIGATION. (pp. 385A - 385A). 0023-6837.
[Conference]Authored by: Hale, T.
Contreras, A., Gutierrez, MC., & Hale, TK.(2010, March). Differential Expression Patterns of the Heterochromatin Proteins HP1 alpha and HP1 beta in Different Tumor Types. MODERN PATHOLOGY. (pp. 385A - 385A). 0893-3952.
[Conference]Authored by: Hale, T.
Contreras, A., Gutierrez, M., & Hale, T. (2010). Differential expression patterns of the heterochromatin proteins HP1 and HP1β in different tumor types. In United States and Canadian Academy of Pathology(pp. 385a - 385a). : Nature Publishing Group
[Conference Abstract]Authored by: Hale, T.
Hale, TK., & Contreras, A. (2009). Is HP1 a Marker of Tumour Progression?. Poster session presented at the meeting of Abcam Chromatin Structure and Function Conference. Costa Rica
[Conference Poster]Authored by: Hale, T.
Hale, TK., Purcell, R., Contreras, A., & Harte, J. (2008). Genetic and epigenetic mechanisms in the pathogenesis of hepatoblastoma. Poster session presented at the meeting of Queenstown Molecular Biology Conference Epigenetics Meeting
[Conference Poster]Authored by: Hale, T.
Hale, TK. (2008, August). The role of the linker histone H1 and HP1 in heterochromatin and tumourigenesis. Presented at QMB Epigenetics Satellite Meeting. Queenstown, New Zealand.
[Conference Oral Presentation]Authored by: Hale, T.
Hale, TK., Purcell, R., Sullivan, M., & Contreras, A. (2008). The role of the linker histone H1 and HP1 in heterochromatin formation and cancer. Poster session presented at the meeting of New Zealand Society of Oncology Meeting. Christchurch, NZ
[Conference Poster]Authored by: Hale, T.
Hale, TK. (2008). The linker histone H1 and HP1 in hetercochromatin formation and cancer. Poster session presented at the meeting of NCI Genome-wide Chromatin Structure and Function Symposium. Washington DC, USA
[Conference Poster]Authored by: Hale, T.
Hale, TK. (2007, August). Histone H1 Phosphorylation in Chromatin Compaction and Tumour Progression. Presented at Queenstown Molecular Biology Conference. Queenstown, New Zealand.
[Conference Oral Presentation]Authored by: Hale, T.
Hale, TK., Sullivan, M., & Herrera, R. (2007). The role of the linker histone H1 in epigenetic regulation and cancer. Poster session presented at the meeting of American Association for Cancer Research Annual Meeting. Los Angeles, USA (14-18 Apr 2007)
[Conference Poster]Authored by: Hale, T.
Hale, TK., Purcell, R., & Contreras, A. (2007). Investigating the role of the linker histone H1 in cancer. Poster session presented at the meeting of Abcam Chromatin Structure and Function Meeting. Antigua
[Conference Poster]Authored by: Hale, T.
Hale, TK. (2006, August). The Linker Histone H1 and its Interaction with HP1. A Histone Code for H1. Presented at Queenstown Molecular Biology Meeting. Queenstown, New Zealand.
[Conference Oral Presentation]Authored by: Hale, T.
Hale, TK. (2006, September). The Beginnings of a ‘Histone Code’ for the Linker Histone H1?. Presented at Gene Expression & Chromatin Symposium. Massey University, Albany.
[Conference Oral Presentation]Authored by: Hale, T.

IP

Doluca, O., Hale, TK., & Filichev, VV.(2013). . 609844: Assembly-dependent Fluorescence Enhancing Nucleic Acids (AFENA) in Sequence-specific Detection of Nucleic Acids in Fluorescence Assay.
[Patent]Authored by: Filichev, V., Hale, T.

Other

Hale, TK. (2007, July). The Fifth Histone - Linker Histone H1 and its Phosphorylation. In Institute for Molecular Biosciences, Massey University (Palmerston North).
[Oral Presentation]Authored by: Hale, T.

Supervision and Teaching

Summary of Doctoral Supervision

Position Current Completed
Supervisor 0 1
Co-supervisor 1 2

Courses Coordinated

Current Doctoral Supervision

Co-supervisor of:

  • Patrick Main - Doctor of Philosophy
    Investigating the role of HDAC4 subcellular distribution neurological development, learning and memory in D. melanogaster

Completed Doctoral Supervision

Supervisor of:

  • 2017 - Sarah Bond - Doctor of Philosophy
    Histone H1 phosphorylation during mitosis

Co-supervisor of:

  • 2018 - Yonathan Lukito - Doctor of Philosophy
    Epigenetic regulation of Epichloë festucae secondary metabolite biosynthesis and symbiotic interaction with Lolium perenne
  • 2017 - Silvia Schwartz - Doctor of Philosophy
    Investigating the role of Histone Deacetylase HDAC4 in long-term memory formation

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