Contact details +64 (06) 356 9099  ext. 84741

Dr Tracy Hale

Senior Lecturer

Institute of Fundamental Sciences

Professional

Contact details

  • Location: ScC2.06
    Campus: Turitea

Research Expertise

Research Interests

Chromatin Biology

Cancer Biology

Thematics

Health and Well-being

Area of Expertise

Field of research codes
Biochemistry and Cell Biology (060100): Biological Sciences (060000):
Cancer Cell Biology (111201):
Cell and Nuclear Division (060402): Epigenetics (incl. Genome Methylation and Epigenomics) (060404): Genetics (060400):
Medical And Health Sciences (110000): Oncology and Carcinogenesis (111200)

Research Projects

Summary of Research Projects

Position Current Completed
Project Leader 2 11

Current Projects

Project Title: Targeting HP1 regulated pathways to suppress breast cell invasion

Date Range: 2016 - 2018

Funding Body: Health Research Council of New Zealand

Project Team:

Research Outputs

Journal

Hale, TK., Norris, GE., Jameson, GB., & Filichev, VV. (2014). Helicases, G4-DNAs, and drug design. ChemMedChem. 9(9), 2031-2034
[Journal article]Authored by: Filichev, V., Hale, T., Jameson, G., Norris, G.
Tretiakova, MS., Bond, SD., Wheeler, D., Contreras, A., Kocherginsky, M., Kroll, TG., . . . Hale, TK. (2014). Heterochromatin protein 1 expression is reduced in human thyroid malignancy. Laboratory Investigation. 94(7), 788-795
[Journal article]Authored by: Hale, T.
Park, JH., Hale, TK., Smith, RJ., & Yang, T. (2014). PPM1B depletion induces premature senescence in human IMR-90 fibroblasts. Mechanisms of Ageing and Development. 138(1), 45-52
[Journal article]Authored by: Hale, T., Park, J.
Doluca, O., Hale, TK., Edwards, PJB., Gonzalez, C., & Filichev, VV. (2014). Assembly dependent fluorescence enhancing nucleic acids in sequence-specific detection of double-stranded DNA. ChemPlusChem. 79(1), 58-66
[Journal article]Authored by: Edwards, P., Filichev, V., Hale, T.
Clausell, J., Happel, N., Hale, T., Doenecke, D., & Beato, M. (2009). Histone H1 subtypes differentially modulate chromatin condensation without preventing ATP-dependent remodeling by SWI/SNF or NURF. PLoS One. 4(10), 1-14
[Journal article]Authored by: Hale, T.
Mandhan, P., Beasley, S., Hale, TK., Ellmers, L., Roake, J., & Sullivan, M. (2006). Sonic hedgehog expression in the development of hindgut in ETU-exposed fetal rats. Pediatric Surgery International. 22, 31-36
[Journal article]Authored by: Hale, T.
Hale, TK., Contreras, A., Morrison, AJ., & Herrera, RE. (2006). Phosphorylation of the linker histone H1 by CDK regulates its binding to HP1α. Molecular Cell. 22(5), 693-699
[Journal article]Authored by: Hale, T.
Hale, TK., & Mansfield, BC. (1989). Nucleotide sequence of a cDNA clone representing a third allele of human protein B23. Nucleic Acids Research. 17(23), 10112
[Journal article]Authored by: Hale, T.

Conference

Lukito, Y., Chujo, T., Hale, TK., Johnson, LJ., & Scott, B. (2017). Regulation of Epichloë festucae secondary metabolite genes by CclA, KdmB and H3K4 trimethylation. Poster session presented at the meeting of QMB Plant-Microbe Interactions Satellite at Queenstown Research Week. Queenstown
[Conference Poster]Authored by: Hale, T.
Lukito, Y., Chujo, T., Hale, T., Johnson, L., & Scott, B. (2016). Histone H3K4 methylation regulates biosynthesis of fungal anti-mammalian alkaloids in an endophyte-plant symbiosis. Poster session presented at the meeting of Third Cold Spring Harbor Laboratory Meeting on Epigenetics & Chromatin
[Conference Poster]Authored by: Hale, T., Scott, D.
Cheng, L., Hale, TK., & Tretiakova, MS.Expression of Heterochromatin Protein 1 in Renal Cortical Tumors and Identification of Its Target Genes. LABORATORY INVESTIGATION. (pp. 221A - 221A). 0023-6837.
[Conference]Authored by: Hale, T.
Cheng, L., Hale, TK., & Tretiakova, MS.Expression of Heterochromatin Protein 1 in Renal Cortical-Tumors and Identification of Its Target Genes. MODERN PATHOLOGY. (pp. 221A - 221A). 0893-3952.
[Conference]Authored by: Hale, T.
Bond, S., & Hale, TK. (2014). Phosphorylation of Histone H1.4 by Aurora B is Required for the Proper Execution of Mitosis. Poster session presented at the meeting of Gordon Conference on Chromatin Structure and Function, Boston, USA. Boston, MA, USA
[Conference Poster]Authored by: Hale, T.Contributed to by: Hale, T.
Hale, TK. (2013, September). Heterochromatin Protein 1 in Cancer. Presented at Queenstown Molecular Biology Meeting Epigenetics Satellite Meeting
[Conference Oral Presentation]Authored by: Hale, T.
Hale, TK. (2011, September). The role of histone H1 and HP1 in tumorigensis. Presented at QMB Epigenetics Satellite Meeting. Queenstown, New Zealand.
[Conference Oral Presentation]Authored by: Hale, T.
Hale, TK., & Bond, S. (2010). Aurora B Phosphorylates Histone H1 During Mitosis. Poster session presented at the meeting of Queenstown Molecular Biology Meeting. Queenstown, New Zealand
[Conference Poster]Authored by: Hale, T.
Contreras, A., Gutierrez, MC., & Hale, TK.(2010, March). Differential Expression Patterns of the Heterochromatin Proteins HP1 alpha and HP1 beta in Different Tumor Types. LABORATORY INVESTIGATION. (pp. 385A - 385A). 0023-6837.
[Conference]Authored by: Hale, T.
Contreras, A., Gutierrez, MC., & Hale, TK.(2010, March). Differential Expression Patterns of the Heterochromatin Proteins HP1 alpha and HP1 beta in Different Tumor Types. MODERN PATHOLOGY. (pp. 385A - 385A). 0893-3952.
[Conference]Authored by: Hale, T.
Contreras, A., Gutierrez, M., & Hale, T. (2010). Differential expression patterns of the heterochromatin proteins HP1 and HP1β in different tumor types. In United States and Canadian Academy of Pathology(pp. 385a - 385a). : Nature Publishing Group
[Conference Abstract]Authored by: Hale, T.
Hale, TK., & Contreras, A. (2009). Is HP1 a Marker of Tumour Progression?. Poster session presented at the meeting of Abcam Chromatin Structure and Function Conference. Costa Rica
[Conference Poster]Authored by: Hale, T.
Hale, TK., Purcell, R., Contreras, A., & Harte, J. (2008). Genetic and epigenetic mechanisms in the pathogenesis of hepatoblastoma. Poster session presented at the meeting of Queenstown Molecular Biology Conference Epigenetics Meeting
[Conference Poster]Authored by: Hale, T.
Hale, TK. (2008, August). The role of the linker histone H1 and HP1 in heterochromatin and tumourigenesis. Presented at QMB Epigenetics Satellite Meeting. Queenstown, New Zealand.
[Conference Oral Presentation]Authored by: Hale, T.
Hale, TK., Purcell, R., Sullivan, M., & Contreras, A. (2008). The role of the linker histone H1 and HP1 in heterochromatin formation and cancer. Poster session presented at the meeting of New Zealand Society of Oncology Meeting. Christchurch, NZ
[Conference Poster]Authored by: Hale, T.
Hale, TK. (2008). The linker histone H1 and HP1 in hetercochromatin formation and cancer. Poster session presented at the meeting of NCI Genome-wide Chromatin Structure and Function Symposium. Washington DC, USA
[Conference Poster]Authored by: Hale, T.
Hale, TK. (2007, August). Histone H1 Phosphorylation in Chromatin Compaction and Tumour Progression. Presented at Queenstown Molecular Biology Conference. Queenstown, New Zealand.
[Conference Oral Presentation]Authored by: Hale, T.
Hale, TK., Sullivan, M., & Herrera, R. (2007). The role of the linker histone H1 in epigenetic regulation and cancer. Poster session presented at the meeting of American Association for Cancer Research Annual Meeting. Los Angeles, USA (14-18 Apr 2007)
[Conference Poster]Authored by: Hale, T.
Hale, TK., Purcell, R., & Contreras, A. (2007). Investigating the role of the linker histone H1 in cancer. Poster session presented at the meeting of Abcam Chromatin Structure and Function Meeting. Antigua
[Conference Poster]Authored by: Hale, T.
Hale, TK. (2006, August). The Linker Histone H1 and its Interaction with HP1. A Histone Code for H1. Presented at Queenstown Molecular Biology Meeting. Queenstown, New Zealand.
[Conference Oral Presentation]Authored by: Hale, T.
Hale, TK. (2006, September). The Beginnings of a ‘Histone Code’ for the Linker Histone H1?. Presented at Gene Expression & Chromatin Symposium. Massey University, Albany.
[Conference Oral Presentation]Authored by: Hale, T.

IP

Doluca, O., Hale, TK., & Filichev, VV.(2013). . 609844: Assembly-dependent Fluorescence Enhancing Nucleic Acids (AFENA) in Sequence-specific Detection of Nucleic Acids in Fluorescence Assay.
[Patent]Authored by: Filichev, V., Hale, T.

Other

Hale, TK. (2007, July). The Fifth Histone - Linker Histone H1 and its Phosphorylation. In Institute for Molecular Biosciences, Massey University (Palmerston North).
[Oral Presentation]Authored by: Hale, T.

Supervision and Teaching

Summary of Doctoral Supervision

Position Current Completed
Supervisor 1 1
CoSupervisor 2 1

Current Doctoral Supervision

Supervisor of:

  • Raoul Solomon - PhD
    Identification of HP1 alpha-regulated pathways that suppress malignant cell invasion

CoSupervisor of:

  • Patrick Main - PhD
    Investigating the role of HDAC4 subcellular distribution neurological development, learning and memory in D. melanogaster
  • Yonathan Lukito - PhD
    Epigenetic regulation of secondary metabolite biosynthesis by Epichloe festucae in symbiosis with Lolium perenne

Completed Doctoral Supervision

Supervisor of:

CoSupervisor of:

  • 2017 - Silvia Schwartz - PhD
    Investigating the role of Histone Deacetylase HDAC4 in long-term memory formation

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