New information following the change in COVID-19 alert levels.

Jolyon Claridge

Doctor of Philosophy, (Science)
Study Completed: 2010
College of Sciences


Thesis Title
Characterisation of an interaction involved in viral replication

Read article at Massey Research Online: MRO icon

Picoraviruses are small RNA viruses that are responsible for polio, foot-and-mouth disease, hepatitis A and the common cold. In my PhD project I was able to use Nuclear Magnetic Resonance to study how these viruses replicate. We were able to determine which parts of a key viral protein and a viral RNA interact, and to effectively visualise their interaction complex. Together with our collaborators, we’ve provided the first detailed insight into the picornaviral replication complex, and hope that the information can be used in the future to combat the associated diseases.

Associate Professor Steven Pascal
Associate Professor Andrew Sutherland-Smith

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