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Gemma Cartwright

Doctor of Philosophy, (Genetics)
Study Completed: 2013
College of Sciences


Thesis Title
Redox regulation of an AP-1-like transcription factor, YapA, in the fungal symbiont Epichloe festucae

Read article at Massey Research Online: MRO icon

Reactive oxygen species can be considered a double edged sword in biological systems, acting as both toxic, damaging molecules and also as important signalling molecules. In a fungal endophyte that colonises perennial ryegrass, reactive oxygen species play an important role in regulating this association. Ms Cartwright explored the molecular mechanisms this endophyte uses to keep levels of reactive oxygen species in check. Her research provides new insight into the regulation and role of a transcription factor in response to oxidative stress. Her results also suggest this symbiotic fungus has a highly redundant and robust system for responding to oxidative stress. Such a system may be crucial for maintenance of a symbiotic lifecycle. 

Professor Barry Scott
Professor Rosie Bradshaw