School of Mathematical and Computational Sciences staff
Contact details +6492136220
Dr Nick Knowlton PhD
Senior Lecturer in Statistics
Doctoral Supervisor School of Mathematical and Computational SciencesDr Nick Knowlton is a Senior Lecturer in Statistics at Massey University. His research focuses on translating biomedical data into evidence, clinical tools and decision-support systems that can improve healthcare and laboratory practice.
Nick works across breast cancer, reproductive medicine and biomedical imaging. He combines statistical analysis, machine learning, computer vision, clinical cohorts, registry data and longitudinal outcomes to answer questions with direct implications for screening, treatment, prognosis and patient care. His primary focus is not methodology in isolation, but whether quantitative research can improve decisions and be implemented reliably in real clinical settings.
In breast cancer, Nick has led and contributed to research on screening, diagnosis, treatment, prognosis and inequities in outcomes. He led the analytical work behind the 30,000 Voices report, a national study of more than 30,000 women with breast cancer in Aotearoa New Zealand. The report subsequently informed national breast cancer quality indicators and health-sector monitoring. His current work includes breast-density assessment, multimodality imaging, risk-stratified screening, survival modelling and analysis of treatment pathways.
In reproductive medicine, Nick develops and evaluates systems for embryo and sperm assessment. His work includes automated analysis of embryo time-lapse imaging, morphokinetic modelling, embryo ranking and image-based reproductive phenotyping. He is co-founder and CEO of WyldBloom, a New Zealand reproductive-technology company translating embryo-imaging and artificial-intelligence research into practical systems for IVF clinics. His role includes clinical partnerships, validation, product strategy, intellectual property, implementation and commercial development.
Nick has previously worked in academic, clinical and commercial diagnostic environments. His earlier work contributed to multivariable diagnostic and risk-assessment systems that progressed into clinical use. This experience shapes his emphasis on external validation, calibration, interpretability, equity and workflow integration. Predictive performance alone is insufficient if a system cannot be trusted, implemented or sustained.
He teaches statistics and applied data science, including within Massey’s Master of Analytics. His teaching connects quantitative methods with real organisational, clinical and commercial decisions. He also leads a postgraduate research environment spanning breast cancer, medical imaging, fertility AI, health economics and applied statistics.
Current projects, publications, teaching resources and supervision opportunities are available at knowlton.co.nz.
Dr Nick Knowlton is a Senior Lecturer in Statistics at Massey University. His work translates biomedical data into evidence, clinical tools and decision-support systems in breast cancer, reproductive medicine and medical imaging. He led the analysis for the national 30,000 Voices breast cancer report and is co-founder and CEO of WyldBloom, which is translating embryo-imaging research into technology for IVF clinics. Nick teaches statistics and applied data science, including in Massey’s Master of Analytics, and supervises postgraduate researchers across biomedical AI, clinical analytics and translational science.
Professional
Contact details
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Location: 64, IC3
Campus: Albany
Qualifications
- Doctor of Philosophy in Molecular Medicine - University of Auckland (2019)
Certifications and Registrations
- Licence, Supervisor, Massey University
Research Expertise
Research Interests
My research examines how biological, clinical and imaging data can be combined to improve prediction, stratification and decision-making in complex health settings.
In breast cancer, I am interested in how screening performance, breast density, tumour biology, treatment, geography and access to care interact across the patient pathway. This includes work on multimodality imaging, prognosis, treatment response, linked registry analysis and variation in outcomes across population groups in Aotearoa New Zealand.
In reproductive science, I study developmental timing and image-based phenotypes in embryos and sperm. Current work includes embryo morphokinetics, cohort-relative embryo ranking, automated developmental-stage recognition, sperm morphology and fertility prediction in human and animal systems.
A recurring question across these programmes is whether a model remains useful when moved beyond the dataset in which it was developed. I therefore focus on validation across clinics, imaging platforms and patient groups, and on identifying where model outputs add information beyond existing clinical assessment.
My wider interests include survival analysis, longitudinal modelling, clinical prediction, computer vision, linked health data, model calibration, health equity and the use of quantitative evidence in clinical and service-level decision-making.
Thematics
Health and Well-being, Future Food Systems
Area of Expertise
Field of research codes
Agricultural Biotechnology (100100):
Applied Statistics (010401):
Artificial Intelligence and Image Processing (080100):
Biostatistics (010402):
Cancer Diagnosis (111202):
Computer Vision (080104):
Information And Computing Sciences (080000):
Mathematical Sciences (010000):
Medical And Health Sciences (110000):
Medical Biotechnology (100400):
Oncology and Carcinogenesis (111200):
Public Health and Health Services (111700):
Statistics (010400):
Technology (100000)
Keywords
Applied biostatistics; biomedical machine learning; computer vision; longitudinal and survival analysis; medical imaging; clinical prediction models; breast cancer epidemiology; reproductive biology and IVF; image-based phenotyping; model validation and calibration; explainable AI; health equity; translational data science
Research Outputs
Journal
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N., Muthukaruppan, A.

[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.

[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.

[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
[Journal article]Authored by: Knowlton, N.
Teaching and Supervision
Teaching Statement
My teaching focuses on making statistical reasoning usable in real analytical settings. I emphasise interpretation, model criticism and decision-making rather than treating methods as isolated formulae or software procedures. Students work with realistic data, incomplete information and ambiguous analytical choices, because these are the conditions under which statistical judgement is actually developed.
I use interactive visualisations, applied coding activities and structured model comparisons to help students connect mathematical ideas with the behaviour of fitted models. This is particularly important in regression, multivariate analysis and applied data science, where students can otherwise reproduce software output without understanding the geometry, assumptions or practical consequences of the analysis.
I also place substantial emphasis on accessibility for mixed-mode and distance learners. My teaching design aims to reduce unnecessary technical barriers while preserving statistical depth. This includes cloud-based analytical environments, downloadable code, reproducible examples and activities that allow students to inspect how results change when assumptions, variables or modelling choices are altered.
My professional work in biomedical research, clinical analytics and technology translation informs my teaching. Examples are drawn from health data, medical imaging, reproductive science and commercial analytics, allowing students to see how statistical methods interact with data governance, implementation constraints, uncertainty and organisational decisions. This is particularly relevant within the Master of Analytics, where graduates need to communicate quantitative evidence to technical and non-technical decision-makers.
Graduate Supervision Statement
My supervision style is collaborative, structured and strongly oriented towards producing research that can be interpreted and used beyond the thesis. I work with students to define a clear scientific or clinical question, establish an auditable analysis plan, identify the limitations of the available data, and connect methodological choices to the decisions the research is intended to inform.
Students are expected to develop independence, but not in isolation. I use regular meetings, written action points, reproducible analytical workflows and staged manuscript development to maintain momentum. Early work usually concentrates on data provenance, outcome definitions, validation strategy and the distinction between exploratory analysis and claims that can be supported. Later supervision focuses on interpretation, writing, publication and translation.
My supervision is interdisciplinary. I work with students from statistics, data science, computer science, medicine and biological sciences, often alongside clinicians, laboratory scientists and external partners. Areas of interest include breast cancer epidemiology and imaging, clinical prediction, linked health data, survival and longitudinal analysis, reproductive medicine, IVF, embryo assessment, sperm phenotyping, biomedical machine learning and computer vision.
I also support a shared postgraduate research environment in which students discuss methods, manuscripts and translational problems across related projects. This allows students to learn from work outside their immediate thesis while developing experience in collaborative research, clinical interpretation and communicating quantitative findings to different audiences. Your current supervision model already operates as an integrated research-training environment rather than a collection of disconnected projects.
Dr Nick Knowlton is not currently available for Masters or Doctoral supervision.
Media and Links
Other Links
- Personal Research Website - Research programmes, publications, teaching resources and postgraduate opportunities
- Google Scholar - Publications and citation record
- LinkedIn - Academic, clinical and enterprise profile
- GitHub - Research software, teaching resources and technical projects
- 30,000 Voices Report - National analysis of breast cancer care and outcomes in Aotearoa New Zealand
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Last updated on Friday 06 March 2026

