Journal
Misaghi, H., Cree, L., & Knowlton, N. (2025). Accurate machine learning model for human embryo morphokinetic stage detection.
Journal of Assisted Reproduction and Genetics. 42(11), 3655-3665
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Roman, IC., Coull, G., Knowlton, N., Doherty-Eagles, T., Ozturk, O., Michielsen, A., . . . Zăhan, M. (2025). Limitations of ploidy prediction by time-lapse morphokinetics and artificial-intelligence-based embryo selection algorithms: trisomies fly under the radar.
Reproductive Biomedicine Online. 51(1)
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Lasham, A., Ramsaroop, R., Wrigley, A., & Knowlton, N. (2024). Analysis of HER2-Low Breast Cancer in Aotearoa New Zealand: A Nationwide Retrospective Cohort Study.
Cancers. 16(18)
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Bathon, JM., Centola, M., Liu, X., Jin, Z., Ji, W., Knowlton, NS., . . . Van Eyk, JE. (2023). Identification of novel biomarkers for the prediction of subclinical coronary artery atherosclerosis in patients with rheumatoid arthritis: an exploratory analysis.
Arthritis Research and Therapy. 25(1)
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Jahedi, H., Ramachandran, A., Windsor, J., Knowlton, N., Blenkiron, C., & Print, CG. (2022). Clinically Relevant Biology of Hyaluronic Acid in the Desmoplastic Stroma of Pancreatic Ductal Adenocarcinoma.
Pancreas. 51(9), 1092-1104
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Hearn, JI., Green, TN., Hisey, CL., Bender, M., Josefsson, EC., Knowlton, N., . . . Kalev-Zylinska, ML. (2022). Deletion of Grin1 in mouse megakaryocytes reveals NMDA receptor role in platelet function and proplatelet formation.
Blood. 139(17), 2673-2690
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Lasham, A., Knowlton, N., Mehta, SY., Braithwaite, AW., & Print, CG. (2021). Breast cancer patient prognosis is determined by the interplay between TP53 mutation and alternative transcript expression: Insights from TP53 long amplicon digital PCR assays.
Cancers. 13(7)
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Lasham, A., Fitzgerald, SJ., Knowlton, N., Robb, T., Tsai, P., Black, MA., . . . Print, CG. (2020). A Predictor of Early Disease Recurrence in Patients With Breast Cancer Using a Cell-free RNA and Protein Liquid Biopsy.
Clinical Breast Cancer. 20(2), 108-116
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Lasham, A., Tsai, P., Fitzgerald, SJ., Mehta, SY., Knowlton, NS., Braithwaite, AW., . . . Print, CG. (2020). Accessing a new dimension in TP53 biology: Multiplex long amplicon digital pcr to specifically detect and quantitate individual TP53 transcripts.
Cancers. 12(3)
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Hearn, JI., Green, TN., Chopra, M., Nursalim, YNS., Ladvanszky, L., Knowlton, N., . . . Kalev-Zylinska, ML. (2020). N-Methyl-D-Aspartate Receptor Hypofunction in Meg-01 Cells Reveals a Role for Intracellular Calcium Homeostasis in Balancing Megakaryocytic-Erythroid Differentiation.
Thrombosis and Haemostasis. 120(4), 671-686
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Lawrence, B., Blenkiron, C., Parker, K., Tsai, P., Fitzgerald, S., Shields, P., . . . Print, C. (2018). Recurrent loss of heterozygosity correlates with clinical outcome in pancreatic neuroendocrine cancer.
Npj Genomic Medicine. 3(1)
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Thomas, A., Routh, ED., Pullikuth, A., Jin, G., Su, J., Chou, JW., . . . Miller, LD. (2018). Tumor mutational burden is a determinant of immune-mediated survival in breast cancer.
Oncoimmunology. 7(10)
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Jamieson, SMF., Tsai, P., Kondratyev, MK., Budhani, P., Liu, A., Senzer, NN., . . . Hunter, FW. (2018). Evofosfamide for the treatment of human papillomavirus-negative head and neck squamous cell carcinoma.
Jci Insight. 3(16)
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Muthukaruppan, A., Lasham, A., Blenkiron, C., Woad, KJ., Black, MA., Knowlton, N., . . . Shelling, AN. (2017). Gene expression profiling of breast tumours from New Zealand patients.
New Zealand Medical Journal. 130(1464), 40-56
[Journal article]Authored by: Knowlton, N., Muthukaruppan, A.Read Abstract:

Jupe, ER., Dalessandri, KM., Mulvihill, JJ., Miike, R., Knowlton, NS., Pugh, TW., . . . Benz, CC. (2014). A steroid metabolizing gene variant in a polyfactorial model improves risk prediction in a high incidence breast cancer population.
Bba Clinical. 2, 94-102
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Centola, M., Cavet, G., Shen, Y., Ramanujan, S., Knowlton, N., Swan, KA., . . . Curtis, JR. (2013). Development of a Multi-Biomarker Disease Activity Test for Rheumatoid Arthritis.
Plos One. 8(4)
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Balachova, T., Bonner, BL., Chaffin, M., Isurina, G., Shapkaitz, V., Tsvetkova, L., . . . Knowlton, N. (2013). Brief FASD prevention intervention: Physicians' skills demonstrated in a clinical trial in Russia.
Addiction Science and Clinical Practice. 8(1)
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Knowlton, N., Wages, JA., Centola, MB., & Alaupovic, P. (2012). Apolipoprotein-defined lipoprotein abnormalities in rheumatoid arthritis patients and their potential impact on cardiovascular disease.
Scandinavian Journal of Rheumatology. 41(3), 165-169
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Knowlton, N., Wages, JA., Centola, MB., Giles, J., Bathon, J., Quiroga, C., . . . Alaupovic, P. (2012). Apolipoprotein B-containing lipoprotein subclasses as risk factors for cardiovascular disease in patients with rheumatoid arthritis.
Arthritis Care and Research. 64(7), 993-1000
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Todd, DJ., Knowlton, N., Amato, M., Frank, MB., Schur, PH., Izmailova, ES., . . . Lee, DM. (2011). Erroneous augmentation of multiplex assay measurements in patients with rheumatoid arthritis due to heterophilic binding by serum rheumatoid factor.
Arthritis and Rheumatism. 63(4), 894-903
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Hansen, KR., Hodnett, GM., Knowlton, N., & Craig, LB. (2011). Correlation of ovarian reserve tests with histologically determined primordial follicle number.
Fertility and Sterility. 95(1), 170-175
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Lee, DM., Jackson, KW., Knowlton, N., Wages, J., Alaupovic, P., Samuelsson, O., . . . Attman, PO. (2011). Oxidative stress and inflammation in renal patients and healthy subjects.
Plos One. 6(7)
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Szodoray, P., Alex, P., Knowlton, N., Centola, M., Dozmorov, I., Csipo, I., . . . Danko, K. (2010). Idiopathic inflammatory myopathies, signified by distinctive peripheral cytokines, chemokines and the TNF family members B-cell activating factor and a proliferation inducing ligand.
Rheumatology. 49(10), 1867-1877
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Carreras, E., Turner, S., Frank, MB., Knowlton, N., Osban, J., Centola, M., . . . Kovats, S. (2010). Estrogen receptor signaling promotes dendritic cell differentiation by increasing expression of the transcription factor IRF4.
Blood. 115(2), 238-246
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Saban, MR., Sferra, TJ., Davis, CA., Simpson, C., Allen, A., Maier, J., . . . Saban, R. (2010). Neuropilin-VEGF signaling pathway acts as a key modulator of vascular, lymphatic, and inflammatory cell responses of the bladder to intravesical BCG treatment.
American Journal of Physiology Renal Physiology. 299(6), F1245-F1256
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Frank, MB., Wang, S., Aggarwal, A., Knowlton, N., Jiang, K., Chen, Y., . . . Jarvis, JN. (2009). Disease-associated pathophysiologic structures in pediatric rheumatic diseases show characteristics of scale-free networks seen in physiologic systems: Implications for pathogenesis and treatment.
BMC Medical Genomics. 2
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Jarvis, JN., Jiang, K., Frank, MB., Knowlton, N., Aggarwal, A., Wallace, CA., . . . Centola, M. (2009). Gene expression profiling in neutrophils from children with polyarticular juvenile idiopathic arthritis.
Arthritis and Rheumatism. 60(5), 1488-1495
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Jiang, K., Krous, LC., Knowlton, N., Chen, Y., Frank, MB., Cadwell, C., . . . Jarvis, JN. (2009). Ablation of Stat3 by siRNA Alters Gene Expression Profiles in JEG-3 Cells: A Systems Biology Approach.
Placenta. 30(9), 806-815
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Knowlton, N., Jiang, K., Frank, MB., Aggarwal, A., Wallace, C., McKee, R., . . . Jarvis, JN. (2009). The meaning of clinical remission in polyarticular juvenile idiopathic arthritis: Gene expression profiling in peripheral blood mononuclear cells identifies distinct disease states.
Arthritis and Rheumatism. 60(3), 892-900
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Nakou, M., Knowlton, N., Frank, MB., Bertsias, G., Osban, J., Sandel, CE., . . . Boumpas, DT. (2008). Gene expression in systemic lupus erythematosus: Bone marrow analysis differentiates active from inactive disease and reveals apoptosis and granulopoiesis signatures.
Arthritis and Rheumatism. 58(11), 3541-3549
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Sawalha, AH., Jeffries, M., Webb, R., Lu, Q., Gorelik, G., Ray, D., . . . Richardson, B. (2008). Defective T-cell ERK signaling induces interferon-regulated gene expression and overexpression of methylation-sensitive genes similar to lupus patients.
Genes and Immunity. 9(4), 368-378
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Hansen, KR., Knowlton, NS., Thyer, AC., Charleston, JS., Soules, MR., & Klein, NA. (2008). A new model of reproductive aging: The decline in ovarian non-growing follicle number from birth to menopause.
Human Reproduction. 23(3), 699-708
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Szodoray, P., Alex, P., Chappell-Woodward, CM., Madland, TM., Knowlton, N., Dozmorov, I., . . . Centola, M. (2007). Circulating cytokines in Norwegian patients with psoriatic arthritis determined by a multiplex cytokine array system.
Rheumatology. 46(3), 417-425
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Alex, P., Szodoray, P., Knowlton, N., Dozmorov, IM., Turner, M., Frank, MB., . . . Centola, M. (2007). Multiplex serum cytokine monitoring as a prognostic tool in rheumatoid arthritis.
Clinical and Experimental Rheumatology. 25(4), 584-592
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Saban, MR., Simpson, C., Davis, C., Wallis, G., Knowlton, N., Frank, MB., . . . Saban, R. (2007). Discriminators of mouse bladder response to intravesical Bacillus Calmette-Guerin (BCG).
BMC Immunology. 8
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Knowlton, N., Dozmorov, I., Kyker, KD., Saban, R., Cadwell, C., Centola, MB., . . . Hurst, RE. (2006). Template-driven gene selection procedure.
IEE Proceedings Systems Biology. 153(1), 4-12
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Dozmorov, MG., Kyker, KD., Saban, R., Knowlton, N., Dozmorov, I., Centola, MB., . . . Hurst, RE. (2006). Analysis of the interaction of extracellular matrix and phenotype of bladder cancer cells.
BMC Cancer. 6
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Szodoray, P., Alex, P., Frank, MB., Turner, M., Turner, S., Knowlton, N., . . . Centola, M. (2006). A genome-scale assessment of peripheral blood B-cell molecular homeostasis in patients with rheumatoid arthritis.
Rheumatology. 45(12), 1466-1476
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Dozmorov, IM., Centola, M., Knowlton, N., & Tang, Y. (2005). Mobile classification in microarray experiments.
Scandinavian Journal of Immunology Supplement. 62(1), 84-91
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Huang, H., Frank, MB., Dozmorov, I., Cao, W., Cadwell, C., Knowlton, N., . . . Anderson, RE. (2005). Identification of mouse retinal genes differentially regulated by dim and bright cyclic light rearing.
Experimental Eye Research. 80(5), 727-739
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Szodoray, P., Alex, P., Jonsson, MV., Knowlton, N., Dozmorov, I., Nakken, B., . . . Centola, M. (2005). Distinct profiles of Sjögren's syndrome patients with ectopic salivary gland germinal centers revealed by serum cytokines and BAFF.
Clinical Immunology. 117(2), 168-176
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Cockrum, KJ., Knowlton, NS., & Centola, MB. (2005). Automated multiplexed cytokine bead assays.
Bio Tech International. 17(5), 19-21
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Dozmorov, I., Saban, MR., Knowlton, N., Centola, M., & Saban, R. (2004). Connective molecular pathways of experimental bladder inflammation.
Physiological Genomics. 15, 209-222
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Dozmorov, I., Knowlton, N., Tang, Y., & Centola, M. (2004). Statistical monitoring of weak spots for improvement of normalization and ratio estimates in microarrays.
BMC Bioinformatics. 5
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Knowlton, N., Dozmorov, IM., & Centola, M. (2004). Microarray data analysis toolbox (MDAT): For normalization, adjustment and analysis of gene expression data.
Bioinformatics. 20(18), 3687-3690
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Dozmorov, I., Knowlton, N., Tang, Y., Shields, A., Pathipvanich, P., Jarvis, JN., . . . Centola, M. (2004). Hypervariable genes--experimental error or hidden dynamics..
Nucleic Acids Research. 32(19), e147
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