Natisha Magan

Citation

Thesis Title
Protein interactions at the human topoisomerase II alpha promoter

Read article at Massey Research Online:

Treatment of cancer is difficult not only due to the physiological and immunological similarities between cancer and normal cells, but also due to the high cardiotoxicity of many treatments. On top of this are the problems related with the development of drug-resistance to chemotherapy. As cancer cells divide rapidly, the proliferation status of a cell can often be a defining characteristic between effective treatments or the development of resistance. Central to the proliferation status of a cell is a protein known as topoisomerase II alpha. Miss Magan outlined a number of factors that can regulate the topoisomerase II alpha gene, which may be important in understanding how this protein can be down-regulated during the development of drug-resistance in some cancers.

Supervisors
Professor Kathryn Stowell
Dr R Isaacs