Contact details +6469517737

Dr Rosemary Brown

Senior Tutor in Biochemistry and Genetics

School of Fundamental Sciences

Research Outputs

Journal

Wang, S., Haapalainen, AM., Yan, F., Du, Q., Tyler, PC., Evans, GB., . . . Schramm, VL. (2012). A picomolar transition state analogue inhibitor of MTAN as a specific antibiotic for helicobacter pylori. Biochemistry. 51(35), 6892-6894
[Journal article]Authored by: Brown, R.
Allen, KA., Brown, RL., Norris, G., Tyler, PC., Watt, DK., & Zubkova, OV. (2010). Syntheses of novel azasugar-containing mimics of heparan sulfate fragments as potential heparanase inhibitors. Carbohydrate Research. 345(13), 1831-1841
[Journal article]Authored by: Brown, R.
Anderson, AA., Brown, RL., Polster, B., Pollock, N., & Stowell, KM. (2008). Identification and biochemical characterization of a novel ryanodine receptor gene mutation associated with malignant hyperthermia. Anesthesiology. 108(2), 208-215
[Journal article]Authored by: Brown, R., Stowell, K.
Gutierrez, JA., Luo, M., Singh, V., Li, L., Brown, RL., Norris, GE., . . . Schramm, VL. (2007). Picomolar inhibitors as transition-state probes of 5′-methylthioadenosine nucleosidases. ACS Chemical Biology. 2(11), 725-734
[Journal article]Authored by: Brown, R.
Singh, V., Luo, M., Brown, RL., Norris, GE., & Schramm, VL. (2007). Transition-state structure of Neisseria meningitides 5′- methylthioadenosine/S-adenosylhomocysteine nucleosidase. Journal of the American Chemical Society. 129(45), 13831-13833
[Journal article]Authored by: Brown, R.
Ho, LW., Brown, RL., Maxwell, M., Wyttenbach, A., & Rubinsztein, DC. (2005). Wild type huntingtin reduces the cellular toxicity of mutant huntingtin in mammalian cell models of Huntington's disease. Journal of Medical Genetics. 38(7), 450-452
[Journal article]Authored by: Brown, R.
Sugars, KL., Brown, RL., Cook, LJ., Swartz, J., & Rubinsztein, DC. (2004). Decreased cAMP response element-mediated transcription. The Journal of Biological Chemistry. 279(6), 4988-4999
[Journal article]Authored by: Brown, R.
Davis, M., Brown, RL., Dickson, A., Horton, H., James, D., Laing, N., . . . Stowell, KM. (2002). Malignant hyperthermia associated with exercise-induced rhabdomyolysis or congenital abnormalities and a novel RYR1 mutation in New Zealand and Australian pedigrees. British Journal of Anaesthesia. 88(4), 508-515
[Journal article]Authored by: Brown, R., Stowell, K.
Ariyaratne, KANS., Brown, R., Dasgupta, A., De Jonge, J., Jameson, GB., Loo, TS., . . . Norris, GE. (2002). Expression of bovine β-lactoglobulin as a fusion protein in Escherichia coli: A tool for investigating how structure affects function. International Dairy Journal. 12(4), 311-318
[Journal article]Authored by: Brown, R., Jameson, G., Loo, T.
Wyttenbach, A., Swartz, J., Kita, H., Thykjaer, T., Carmichael, J., Bradley, J., . . . Rubinsztein, DC. (2001). Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease. Human Molecular Genetics. 10(17), 1829-1845
[Journal article]Authored by: Brown, R.
Chamley, D., Pollock, AN., Stowell, KM., & Brown, RL. (2000). Malignant hyperthermia in infancy and identification of novel RYR1 mutation. British Journal of Anaesthesia. 84(4), 500-504
[Journal article]Authored by: Brown, R., Stowell, K.
Brown, RL., Neil Pollock, A., Couchman, KG., Hodges, M., Hutchinson, DO., Waaka, R., . . . Stowell, KM. (2000). A novel ryanodine receptor mutation and genotype-phenotype correlation in a large malignant hyperthermia New Zealand Maori pedigree. Human Molecular Genetics. 9(10), 1515-1524
[Journal article]Authored by: Brown, R., Stowell, K.
Chamley, D., Pollock, NA., Stowell, KM., & Brown, RL. (2000). Malignant hyperthermia in infancy and identification of novel RYR1 mutation. British Journal of Anaesthesia. 84(4), 500-504
[Journal article]Authored by: Brown, R., Stowell, K.
Brown, RL., Baker, HM., Jameson, GB., Scopes, RK., & Baker, EN. (1996). Crystallization and preliminary X-ray diffraction studies of a cobalt-substituted derivative of the iron-dependent alcohol dehydrogenase from Zymomonas mobilis. Acta Crystallographica Section D: Biological Crystallography. 52(1), 218-220
[Journal article]Authored by: Brown, R., Jameson, G.
Baker, HM., Brown, RL., Dobbs, AJ., Blackwell, LF., Buckley, PD., Hardman, MJ., . . . Baker, EN. (1994). Crystallization and preliminary X-ray diffraction studies on cytosolic (Class 1) aldehyde dehydrogenase from sheep liver. Journal of Molecular Biology. 241(2), 263-264
[Journal article]Authored by: Brown, R.

Thesis

Brown, RL. (2000). A genetic test for malignant hyperthermia. (Doctoral Thesis, Massey University, Palmerston North)
[Doctoral Thesis]Authored by: Brown, R.

Conference

Baker, HM., Brown, RL., Dobbs, AJ., Kitson, KE., Kitson, TM., & Baker, EN.Crystallization of sheep liver cytosolic aldehyde dehydrogenase in a form suitable for high resolution X-ray structural analysis. Advances in Experimental Medicine and Biology. (pp. 67 - 70). 0065-2598.
[Conference]Authored by: Brown, R.

Other

Wang, S., Haapalainen, AM., Yan, F., Du, Q., Tyler, PC., Evans, GB., . . . Schramm, VL. (2012). 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from H. pylori.
[Dataset]Authored by: Brown, R.
Brown, RL., Anderson, BF., Tyler, PC., Evans, GB., Sutherland-Smith, AJ., & Norris, GE. (2012). S-Adenosylhomocysteine Nucleosidase from S. aureus.
[Dataset]Authored by: Brown, R., Sutherland-Smith, A.
Ponniah, K., Norris, GE., Anderson, BF., Brown, RL., Tyler, PC., Evans, GB., . . . Frolich, R. (2012). Crystal structure of s-adenosylhomocysteine nucleosidase from streptococcus pyogenes in complex with 5-methylthiotubericidin;.
[Dataset]Authored by: Brown, R.

Teaching and Supervision

Courses Coordinated