Associate Professor Evelyn Sattlegger staff profile picture

Contact details +6492136502

Associate Professor Evelyn Sattlegger PhD, MSc, BSc

Associate Professor in Metabolic Biochemistry

Doctoral Mentor Supervisor
School of Fundamental Sciences

The research in my group has a large variety of applications which in part are overlapping.  For example: Health: Exact knowledge of GCN2-function will help to fight disorders that involve GCN2 such as Alzheimer’s disease, other neurological disorders, rejection of organ transplants, viral defense, virulence of Eukaryotic pathogens (e.g. fungi), eating disorders, drug side effects, heart disease, cancer.  For example, we are investigating new drug targets to better fight cancer, and we have recently discovered new anti-cancer drug leads.  Biotechnology: The fact that GCN2 regulates protein synthesis, and thereby the performance of cells, this implies that knowledge of its exact function will aid in the improvement of organisms for biotechnological applications.  Also, our extensive Molecular Biology expertise has allowed us to contribute to developing molecular biology apporaches to detect disease-causing bacteria in Food.  Basic research: Our work offers opportunities to explore the fascinating complexity of protein functions and of cross-regulations of signaling pathways.  Basic knowledge forms the crucial foundation for health and applied research.  Student training:  Yeast is very easy to handle, non toxic, cheap to maintain, fast growing, and it can be used to learn a large array of techniques.  Yeast allows comprehensive studies as it is amenable to a large variety of techniques, such as molecular, biochemical, cellular and genetic techniques, all techniques used in Biotechnology, which we all employ.  Also, we are using mammalian cell lines for some of our studies.

more information can be found at http://www.sattlegger-lab.webs.com

 

Roles and Responsibilities
Research and Teaching,
Chairing the Postgraduate Committee for the School of Natural and Computational Sciences and the New Zealand Instiute of Advnaced Study. 

EXPERTISE and INTERESTS
>>  Basic Biomedical Research aimed at understanding the molecular mechanisms occurring in a healthy organism, how diseases and disorders develop, and how they can be prevented or treated.  For example, we have recently discovered promising new anti-cancer drug leads  We apply a variety of techniques in the fields of Molecular Biology/Genetics, Genetics, Cell Biology, to Biochemistry, Biotechnology
>>  Applying molecular techniques in Food Microbiology, e.g. to detect disease-causing bacteria.
>>
 Teach and mentor undergraduate, postgraduate and doctoral students, and emerging researchers

More about me...View less...

Professional

Contact details

  • Ph: +64 (0)9 414 0800 extn 43502
    Location: 4, Building 14
    Campus: Albany

Qualifications

  • Doctor of Philosophy - University of Hannover (1996)
  • Master of Science - University of Hannover (1992)
  • Bachelor of Science - University of Hannover (1988)

Certifications and Registrations

  • Licence, Mentor Supervisor, Massey University

Research Expertise

Research Interests

> Basic Biomedical Research aimed at understanding the molecular mechanisms occurring in a healthy organism, how diseases and disorders develop, and how they can be prevented or treated.  As model organism we use mammalian cell lines and baker’s yeast (which on the cellular level is very similar to human cells) and mammalian cell lines. 

> We apply a variety of techniques in the fields of Molecular Biology/Genetics, Genetics, Cell Biology, to Biochemistry, Biotechnology. Open to collaborations.

> Applying molecular techniques in Food Microbiology, to detect disease-causing bacteria.

> Teach and mentor undergraduate, postgraduate and doctoral students, and emerging researchers

Research Opportunities

  • MSc, BSc(hons), PGDip  (01/06/2019) Several projects available, please inquire, email e.sattlegger@massey.ac.nz. Several start dates possible, just had to put in some date in this form.

Thematics

21st Century Citizenship, Resource Development and Management, Health and Well-being, Future Food Systems

Area of Expertise

Field of research codes
Biochemistry and Cell Biology (060100): Biological Sciences (060000): Genetics (060400):
Medical And Health Sciences (110000):
Microbiology (060500): Other Biological Sciences (069900)

Keywords

EXPERTISE and INTERESTS
>> Basic Biomedical Research aimed at understanding the molecular mechanisms occurring in a healthy organism, how diseases and disorders develop, and how they can be prevented or treated.  As model organism we use mammalian cell lines and baker’s yeast (which on the cellular level is very similar to human cells, but much cheaper to work with, and due to its faster growth rate helps generate data within shorter time frames).  We apply a variety of techniques in the fields of Molecular Biology/Genetics, Genetics, Cell Biology, to Biochemistry, Biotechnology
Of high interest is the enzyme Gcn2.  Gcn2 is involved in many key biological processes, such as amino acid and fatty acid homeostasis, regulation of protein synthesis, forestalling nutrient starvation, UV and oxidative stress, controlling cell division, etc. It has being implicated in the immune system and with cancer, long term memory formation, feeding behaviour, and more
>>  Applying molecular techniques in Food Microbiology, to detect disease-causing bacteria.
>>
Teach and mentor undergraduate, postgraduate and doctoral students, and emerging researchers

Research Projects

Summary of Research Projects

Position Current Completed
Project Leader 3 26

Consultancy and Languages

Languages

  • German
    Last used: - current
    Spoken ability: Excellent
    Written ability: Excellent
  • English
    Last used: - current
    Spoken ability: Excellent
    Written ability: Excellent

Teaching and Supervision

Teaching Statement

Undergraduate courses:

122.101 - Biochemistry of Cells

122.233 - Metabolic Biochemistry (course coordinator)

162.101 - Biology of Cells (course coordinator)

203.340 - Applied Molecular Biology

Postgraduate courses:

122.703 - Gene expression (couse coordinator)

122.704 - Molecular Cell Biology (course coordinator only)

162.760 - Research Methods (course coordinator)

and other xxx.7xx courses as required

Courses Coordinated

Summary of Doctoral Supervision

Position Current Completed
Main Supervisor 2 5
Co-supervisor 1 3

Current Doctoral Supervision

Main Supervisor of:

  • Reuben Anderson - Doctor of Philosophy
    In-depth characterisation of a protein-protein interaction
  • Susanne Gottfried - Doctor of Philosophy
    Characterization of a cellular property, and its suitability for fighting cancer

Co-supervisor of:

  • Jinting Zhu - Doctor of Philosophy
    Artificial Intelligence approaches for malware detection

Completed Doctoral Supervision

Main Supervisor of:

  • 2019 - Hayley Prescott - Doctor of Philosophy
    Studies Toward Evaluating Gcn2 as a Drug Target
  • 2016 - Rashmi Ramesh - Doctor of Philosophy
    Unravelling the dynamics of protein- protein interactions in the Gcn2 signal transduction pathway
  • 2015 - Renuka Shanmugam - Doctor of Philosophy
    Identification of Gcn1 binding proteins and characterization of their effect on Gcn2 function
  • 2012 - Martina Dautel - Doctor of Philosophy
    Shedding light on the link between the actin cytoskeleton and stress response in Saccharomyces cerevisiae
  • 2011 - Jyothsna Visweswaraiah - Doctor of Philosophy
    Discovering links between elongation factors and general amino acid control in Saccharomyce cerevisiae

Co-supervisor of:

  • 2012 - Katie Hartnup - Doctor of Philosophy
    Ancient DNA Analysis of Maori Feather Cloaks and Kete: Implications for Conservation and Culture
  • 2011 - Elmira Mohandesan - Doctor of Philosophy
    The evolution of the Mitochondrial DNA in Tuatara (Sphenodon punctatus)
  • 2011 - William Waugh - Doctor of Philosophy
    DNA Barcoding the Birds of New Zealand

Media and Links

Other Links

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